Results 41 to 50 of about 3,811,869 (264)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

A gene catalogue of the amphioxus nervous system

open access: yesInternational Journal of Biological Sciences, 2006
The elaboration of extremely complex nervous systems is a major success of evolution. However, at the dawn of the post-genomic era, few data have helped yet to unravel how a nervous system develops and evolves to complexity.
Èlia Benito-Gutiérrez
doaj  

Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines

open access: yesMolecular Therapy: Nucleic Acids, 2019
mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to fully realizing the potential of mRNA vaccines. Pre-
Kimberly J. Hassett   +18 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Impact of intermediate and high energy nuclear data on the neutronic safety parameters of MYRRHA accelerator driven system

open access: yesEPJ Web of Conferences, 2017
Perturbation of external neutron source can cause significant local power changes transformed into undesired safety-related events in an accelerator driven system.
Stankovskiy Alexey   +2 more
doaj   +1 more source

Karl Marx - 200 anos

open access: yesRumores, 2019
Com a efeméride das comemorações de duzentos anos do nascimento de Karl Marx, o texto apresenta as quatro fases de sua trajetória enquanto jornalista e debate quais características desta práxis noticiosa podem ser relevantes para uma teoria da prática ...
Rafael Bellan Rodrigues de Souza
doaj   +1 more source

DRONE BASED NEAR REAL-TIME HUMAN DETECTION WITH GEOGRAPHIC LOCALIZATION [PDF]

open access: yesThe International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2019
Detection of humans, e.g. for search and rescue operations has been enabled by the availability of compact, easy to use cameras and drones. On the other hand, aerial photogrammetry techniques for inspection applications allow for precise geographic ...
P. J. Baeck   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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