Results 71 to 80 of about 18,261,697 (295)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

An Archaeology of Food: A Case Study From Roman Britain

Theoretical Roman Archaeology Journal, 2001
None
Gillian Hawkes
doaj   +2 more sources

Tuberculosis 2000 [PDF]

Journal of the Royal Society of Medicine, 1996
P D, Davies, K M, De Cock, J, Leese, J, Moore-Gillon   +3 more
openaire   +2 more sources

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Modelo Sistema de Gestión de Calidad en el proceso enseñanza-aprendizaje en México

Revista Visión Gerencial, 2008
Se presenta una propuesta de Modelo de Sistema de Gestión de Calidad, para dependencias de educación superior. El propósito es impulsar en las instituciones responsables de la formación profesional, la visión de implementar una cultura de evaluación y ...
Jesús Lavín Verástegui, Norma Angélica Pedraza Melo, Maritza Álvarez Herrera   +2 more
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Modelo multicriterio para determinar el beneficio derivado de la implementación de un sistema de gestión de calidad según la norma ISO 9001:2000

Revista Facultad de Ingeniería Universidad de Antioquia, 2010
Muchas empresas manufactureras implementan sistemas de gestión de la calidad ISO 9001:2000 forzadas por las exigencias del mercado o por no quedarse atrás con respecto a la competencia; pero una vez realizado el proceso de implantación del sistema, surge
Juan Carlos Osorio Gómez, Eliana Díaz Mosquera, Katherine Garro Astudillo   +2 more
doaj  

The development of mouthwashes without anti-gonococcal activity for controlled clinical trials: an in vitro study [version 1; peer review: 2 approved]

F1000Research, 2019
Background: The oropharynx plays a major role in the development and spread of antimicrobial resistant Neisseria gonorrhoeae among men who have sex with men.
Christophe Van Dijck, Vicky Cuylaerts, Piet Sollie, Anna Spychala, Irith De Baetselier, Jolein Laumen, Tania Crucitti, Chris Kenyon   +7 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source