Results 61 to 70 of about 5,028,694 (249)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

An Archaeology of Food: A Case Study From Roman Britain

Theoretical Roman Archaeology Journal, 2001
None
Gillian Hawkes
doaj   +2 more sources

An official's rubber dinghy at the yachting, Sydney 2000 Olympic Games, 24 September 2000 [picture] /

, 2000
Title from the descriptive list.; Marathon, sailing and athletics events, Sydney 2000 Olympic Games, 24 September ...
Seselja, Loui, 1948-
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Modelo Sistema de Gestión de Calidad en el proceso enseñanza-aprendizaje en México

Revista Visión Gerencial, 2008
Se presenta una propuesta de Modelo de Sistema de Gestión de Calidad, para dependencias de educación superior. El propósito es impulsar en las instituciones responsables de la formación profesional, la visión de implementar una cultura de evaluación y ...
Jesús Lavín Verástegui, Norma Angélica Pedraza Melo, Maritza Álvarez Herrera   +2 more
doaj  

Sailing Marshal's red rubber dinghy, Soling class sailing, Sydney 2000 Olympic Games, 24 September 2000 [picture] /

, 2000
Title from the descriptive list.; Marathon, sailing and athletics events, Sydney 2000 Olympic Games, 24 September ...
Seselja, Loui, 1948-
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Hockey, men's, Argentina play Poland, Sydney 2000 Olympic Games, 21 September 2000 [3] [picture] /

, 2000
Title from the descriptive list.; Part of collection: Hockey, archery and fencing events, Sydney 2000 Olympic Games, 21 September ...
Seselja, Loui, 1948-
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Modelo multicriterio para determinar el beneficio derivado de la implementación de un sistema de gestión de calidad según la norma ISO 9001:2000

Revista Facultad de Ingeniería Universidad de Antioquia, 2010
Muchas empresas manufactureras implementan sistemas de gestión de la calidad ISO 9001:2000 forzadas por las exigencias del mercado o por no quedarse atrás con respecto a la competencia; pero una vez realizado el proceso de implantación del sistema, surge
Juan Carlos Osorio Gómez, Eliana Díaz Mosquera, Katherine Garro Astudillo   +2 more
doaj