Results 61 to 70 of about 18,261,697 (295)
Medicine, Culture and Military Identity
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Patricia A. Barker
doaj +2 more sources
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
El voto económico en las elecciones de 1996 y 2000: una comparación
El artículo comprueba la hipótesis del voto económico en las elecciones generales de1996 y 2000. Argumenta que es necesario reflexionar sobre la lógica de la teoría delvoto económico y traducirla en términos empíricos de una manera más sofisticada quela ...
Marta Fraile
doaj
Unpicking a Myth: The Infanticide of Female and Disabled Infants in Antiquity
None
Eleanor Scott
doaj +2 more sources
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Representing Londinium: The Influence of Colonial and Post-Colonial Discourses
None
Francis Grew
doaj +2 more sources
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Writing Colonial Conflict, Acknowledging Colonial Weakness
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Garrick Fincham
doaj +2 more sources

