Results 31 to 40 of about 6,497,507 (282)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Deaths of children and young people, Queensland 2013–14 [PDF]
, 2014 The deaths of 446 children and young people were registered in 2013–14, representing a rate of 41.0 deaths per 100,000 population aged 0–17 years. Over the ten year period of data collection there has been a general reduction in the rates in the most ...
Queensland Family and Child Commission
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Health expenditure Australia 2013–14 [PDF]
, 2015 This report includes estimates of how much was spent on health between 2003–04 and 2013–14. This information contributes to understanding the performance and efficiency of Australia’s health system and how changes arise over time.
Australian Institute of Health and Welfare
core
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Non-admitted patient care 2013–14: Australian hospital statistics [PDF]
, 2015 In 2013–14, about 46 million occasions of service were provided for non-admitted patients by 558 public hospitals. Summary Non-admitted patient care includes emergency occasions of service for non-admitted patients, outpatient care (including ...
Australian Institute of Health and Welfare
core
مجلة حوليات التراث العدد 13 [PDF]
Annales du Patrimoine, 2013 مجلة حوليات التراث، كلية الآدب والفنون، جامعة مستغانم، الجزائر، العدد 13 ...
د. محمد عباسة
doaj
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source