Results 81 to 90 of about 2,265,448 (242)

Immunosenescence and Vaccine Efficacy in Aging: Dynamic Interplay of Gut Microbiota and mTOR Signaling Pathways

Aging Cell, Volume 25, Issue 6, June 2026.
Aging impairs vaccine efficacy through gut microbiota dysbiosis and mTOR hyperactivation, which together drive inflammaging and weaken immune memory. This review highlights the bidirectional microbiota–mTOR axis and proposes that combining mTOR inhibitors with microbiota modulation offers a promising strategy to enhance vaccine responses in older ...
Jiaxuan Li, Yuhong Zhang, Daijun Yu, Jianhua Li, Keda Chen, Lisheng Chu   +5 more
wiley   +1 more source

Promising Inhibitor for 2019-nCoV in Drug Development

, 2020
The 2019 novel coronavirus (2019-nCoV), which is first detected in Wuhan, China, is a virus identified as the cause of pneumonia. In the event of epidemic outbreak, a series of actions have taken by the Chinese government to control the pandemic of the ...
Zilong Dang, Xiaohui Xu
core   +1 more source

Regulatory Approaches in the Face of a Pandemic: Assessing the Role of Ideology, Context, and Rule Design in Four Spanish Regions

Public Administration, Volume 104, Issue 2, Page 239-250, June 2026.
ABSTRACT Regulatory instruments to manage the COVID‐19 pandemic have been the object of rich scholarly debates, primarily focused on early national responses to the crisis. We investigate variation in sub‐national regulatory approaches when a crisis is normalized, its association with competing political ideas about the health‐economy trade‐off and the
Salvador Parrado, Roberta Perna, Carlos Closa, Manuel Pereira‐Puga   +3 more
wiley   +1 more source

Near‐Source Wastewater Surveillance of SARS‐CoV‐2, Influenza A, and Respiratory Syncytial Virus With Spatiotemporal Evaluation of Pepper Mild Mottle Virus as a Fecal Indicator

Water Environment Research, Volume 98, Issue 5, May 2026.
Wastewater surveillance results showed a 0–8 day early warning compared to clinical data depending on the type of virus that was investigated. ABSTRACT Wastewater‐based epidemiology (WBE) is increasingly transitioning from treatment plant scale monitoring toward community‐scale surveillance to provide higher spatial resolution.
Yuzhu Mao, Chunfu Liu, Rushan Abayagunawardena, Kosala Desilva, Patricia Arcellana, Birthe V. Kjellerup   +5 more
wiley   +1 more source

Infection of 5xFAD mice with a mouse‐adapted SARS‐CoV‐2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The COVID‐19 pandemic underscored the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection on worsening the severity of Alzheimer's disease (AD) neuropathology and disease progression. METHODS Aged 5xFAD and wild‐type (WT) mice were infected with a mouse‐adapted SARS‐CoV‐2 (MA10), and extensive ...
Susana Furman, Latifa Zayou, Kate Inman Tsourmas, Dominic Ibarra Javonillo, Gema M. Olivarria, Yuting Cheng, Collin Pachow, Kellie Fernandez, Lucas Le, Robert A. Edwards, Dequina A. Nicholas, Gabriela Pacheco Sanchez, Ralph S. Baric, Kim N. Green, Thomas E. Lane   +14 more
wiley   +1 more source

COVID-2019: update on epidemiology, disease spread and management

Monaldi Archives for Chest Disease, 2020
With each passing day, more cases of Coronavirus disease (COVID-2019) are being detected and unfortunately the fear of novel corona virus 2019 (2019-nCoV) becoming a pandemic disease has come true.
Kamal Kant Sahu, Ajay Kumar Mishra, Amos Lal   +2 more
doaj   +1 more source

Transmission routes of 2019-nCoV and controls in dental practice

, 2020
A novel β-coronavirus (2019-nCoV) caused severe and even fetal pneumonia explored in a seafood market of Wuhan city, Hubei province, China, and rapidly spread to other provinces of China and other countries. The 2019-nCoV was different from SARS-CoV, but
Li, Yuqing, Ren, Biao, Xin Xu, Xuedong Zhou, Peng, Xian, Xu, Xin, Cheng, Lei, Xian Peng, Lei Cheng, Zhou, Xuedong, Biao Ren, Yuqing Li   +11 more
core   +1 more source

Surmounting Recalcitrant Airway Inflammatory Disorders With a Multi‐Targeting Therapeutic Strategy by Tannic Acid‐Modified CuInP2S6 Nanosheets

Exploration, Volume 6, Issue 2, April 2026.
Our findings underscore a multi‐targeting strategy for severe airway inflammation that multi‐targeting nanoformulation C‐TA1 markedly attenuated airway inflammation by (1) cfDNA elimination to alleviate neutrophilic/eosinophilic inflammation mediated by the TLR9 pathway, (2) prevention of RONS‐induced tissue injury and inflammatory response, (3 ...
Ming Liu, Changyi Xu, Renqiang Ma, Xinran Xie, Ying Xie, Mengya Du, Zhaofeng Xu, Shuaiyin Zhang, Jian Li, Weiping Wen, Zhaoxu Tu   +10 more
wiley   +1 more source

From Immunization to Autoimmunity: A Deep Dive Into Post‐COVID‐19 Vaccine Reactions—A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Coronavirus disease‐2019 (COVID‐19) emerged in 2019 from Wuhan, China, leading to the accelerated development of vaccines, which have proven instrumental in controlling the spread of the virus. While vaccination ceased the increasing trend of the viral infection, rare adverse autoimmune events emerged as important ...
Mohammad Javad Yousefi‐Hashemabad, Saeed Hashemi, Kiarash Saleki, Seyed Mohamad Kazem Nourbakhsh, Andia Saleki, Zahra Hassanzadeh, Abbas Azadmehr   +6 more
wiley   +1 more source

CORONAVIRUS DISEASE 2019 (COVID-19)

Journal of University Medical & Dental College, 2020
The epidemic of 2019 novel coronavirus (2019-nCoV) has been emerged from a major city named Wuhan in the Hubei Province of China. It appears to have the potential to cause a major health problem globally. Earlier it is called 2019-nCoV but now this virus
Aysha Azhar
doaj   +1 more source