Results 1 to 10 of about 39,409 (160)

Broad betacoronavirus neutralization by a stem helix–specific human antibody [PDF]

Science, 2021
The spillovers of betacoronaviruses in humans and the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad coronavirus countermeasures.
Dora Pinto, Maximilian M Sauer, Nadine Czudnochowski   +2 more
exaly   +5 more sources

Recombination and Positive Selection Differentially Shaped the Diversity of Betacoronavirus Subgenera

Viruses, 2020
The Betacoronavirus genus of mammal-infecting viruses includes three subgenera (Sarbecovirus, Embecovirus, and Merbecovirus), in which most known human coronaviruses, including SARS-CoV-2, cluster.
Diego Forni, Rachele Cagliani, Manuela Sironi   +2 more
exaly   +2 more sources

Identification, Isolation, and Molecular Characterization of Betacoronavirus in Oryx leucoryx

Microbiology Spectrum, 2023
Coronaviruses (CoVs) are enveloped viruses with a large RNA genome (26 to 32 kb) and are classified into four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus, and Deltacoronavirus.
Dan David, Jimmy Asiku, Nick Storm, Katya Lapin, Asaf Berkowitz, Anita Kovtunenko, Nir Edery, Roni King, Asaf Sol   +8 more
doaj   +2 more sources

RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in Betacoronavirus

RNA Biology, 2022
: Similar to other RNA viruses, the emergence of Betacoronavirus relies on cross-species viral transmission, which requires careful health surveillance monitoring of protein-coding information as well as genome-wide analysis.
Alexis Felipe Rojas-Cruz, Juan CARLOS Gallego-Gómez, Clara Isabel Bermudez-Santana   +2 more
exaly   +2 more sources

Conserved Molecular Signatures in the Spike, Nucleocapsid, and Polymerase Proteins Specific for the Genus Betacoronavirus and Its Different Subgenera

Genes, 2022
The genus Betacoronavirus, consisting of four main subgenera (Embecovirus, Merbecovirus, Nobecovirus, and Sarbecovirus), encompasses all clinically significant coronaviruses (CoVs), including SARS, MERS, and the SARS-CoV-2 virus responsible for current ...
Radhey S Gupta, Bijendra Khadka, Gupta Radhey S   +2 more
exaly   +3 more sources

Human Betacoronavirus 2c EMC/2012–related Viruses in Bats, Ghana and Europe [PDF]

Emerging Infectious Diseases, 2013
We screened fecal specimens of 4,758 bats from Ghana and 272 bats from 4 European countries for betacoronaviruses. Viruses related to the novel human betacoronavirus EMC/2012 were detected in 46 (24.9%) of 185 Nycteris bats and 40 (14.7%) of 272 ...
Augustina Angelina Sylverken, VÍCTOR M Corman, Michael Owusu   +2 more
exaly   +2 more sources

Novel Betacoronavirus in Dromedaries of the Middle East, 2013

Emerging Infectious Diseases, 2014
In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were ...
Patrick C Y Woo, Susanna K P Lau, Emily Y M Wong   +2 more
exaly   +2 more sources

Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals

, 2023
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated that coronaviruses specifically target kinase cascades to subvert host cell ...
Emily A. Madden (12890646), Nathaniel J. Moorman (12890661), Lee M. Graves (425633), Amy C. Sims (7408214), Longping V. Tse (7256294), Timothy M. Willson (1276791), Carrow I. Wells (1453441), Natalie K. Barker (14851456), Ralph S. Baric (7408220), Izabella N. Castillo (14375196), Kenneth H. Dinnon (16888897), Yixuan J. Hou (10937277), Thomas S.K. Gilbert (15133736), Laura E. Herring (3046809), Ethan J. Fritch (16888894), Angie L. Mordant (16362957), Premkumar Lakshmanane (11484419), Xuan Yang (1395235)   +17 more
core   +11 more sources

Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?

Journal of Infection, 2012
Fouchier et al. reported the isolation and genome sequencing of a novel coronavirus tentatively named " human betacoronavirus 2c EMC/2012 (HCoV-EMC)" from a Saudi patient presenting with pneumonia and renal failure in June 2012.
Jasper Fuk-Woo Chan, Kenneth S M Li, Kelvin Kai-Wang To   +2 more
exaly   +2 more sources

Paradoxical G-quadruplex distribution in coronavirus genomes reveals functional constraints and antiviral therapeutic opportunities [PDF]

Virus Research
We computationally characterized G-quadruplex (G4) distributions across 31 coronavirus genomes to identify conserved structural features as potential antiviral therapeutic targets.
Masato Tanigawa, Takafumi Iwaki
doaj   +2 more sources