Results 11 to 20 of about 41,690 (230)

Identification, Isolation, and Molecular Characterization of Betacoronavirus in Oryx leucoryx

Microbiology Spectrum, 2023
Coronaviruses (CoVs) are enveloped viruses with a large RNA genome (26 to 32 kb) and are classified into four genera: Alphacoronavirus, Betacoronavirus, Gammacoronavirus, and Deltacoronavirus.
Dan David, Jimmy Asiku, Nick Storm, Katya Lapin, Asaf Berkowitz, Anita Kovtunenko, Nir Edery, Roni King, Asaf Sol   +8 more
doaj   +5 more sources

Alpha- and betacoronavirus cis-acting RNA elements. [PDF]

Current Opinion in Microbiology
Coronaviruses have exceptionally large RNA genomes and employ multiprotein replication/transcription complexes to orchestrate specific steps of viral RNA genome replication and expression.
Ramakanth Madhugiri, H. Nguyen, H. Slanina, J. Ziebuhr   +3 more
semanticscholar   +4 more sources

Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals. [PDF]

Journal of Proteome Research, 2023
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated that coronaviruses specifically target kinase cascades to subvert host cell ...
Ethan J. Fritch, A. Mordant, Thomas S. K. Gilbert, C. Wells, Xuan Yang, Natalie K Barker, E. A. Madden, Kenneth H. Dinnon, Y. Hou, Long-Ping V. Tse, Izabella Castillo, A. Sims, Nathaniel J. Moorman, Premkumar Lakshmanane, T. Willson, Laura E. Herring, L. Graves, R. Baric   +17 more
semanticscholar   +12 more sources

Betacoronavirus-specific alternate splicing [PDF]

Genomics, 2021
Abstract Viruses can subvert a number of cellular processes in order to block innate antiviral responses, and many viruses interact with cellular splicing machinery. SARS-CoV-2 infection was shown to suppress global mRNA splicing, and at least 10 SARS-CoV-2 proteins bind specifically to one or more human RNAs.
Guy Karlebach, Bruce Aronow, Stephen B. Baylin, Daniel Butler, Jonathan Foox, Shawn Levy, Cem Meydan, Christopher Mozsary, Amanda M Saravia-Butler, Deanne M Taylor, Eve Wurtele, Christopher E Mason, Afshin Beheshti, Peter N Robinson   +13 more
openaire   +5 more sources

Novel Betacoronavirus in Dromedaries of the Middle East, 2013 [PDF]

Emerging Infectious Diseases, 2014
In 2013, a novel betacoronavirus was identified in fecal samples from dromedaries in Dubai, United Arab Emirates. Antibodies against the recombinant nucleocapsid protein of the virus, which we named dromedary camel coronavirus (DcCoV) UAE-HKU23, were detected in 52% of 59 dromedary serum samples tested.
Mareena, R, Yuen, KY, Fan, YY, Cai, J, Sivakumar, S, Lau, CY, Tsang, KL, Johnson, B, Woo, PCY, Wong, YM, Lau, SKP, Wernery, U, Yip, CY, Chan, KH   +13 more
openaire   +5 more sources

The coevolutionary mosaic of bat betacoronavirus emergence risk

Virus Evolution, 2023
Pathogen evolution is one of the least predictable components of disease emergence, particularly in nature. Here, building on principles established by the geographic mosaic theory of coevolution, we develop a quantitative, spatially explicit framework ...
Norma R. Forero-Muñoz, R. de Lara Muylaert, S. Seifert, Gregory F. Albery, D. Becker, Colin J. Carlson, T. Poisot   +6 more
semanticscholar   +4 more sources

Discovery and Characterization of a Pan-betacoronavirus S2-binding antibody

Structure
Three coronaviruses have spilled over from animal reservoirs into the human population and caused deadly epidemics or pandemics. The continued emergence of coronaviruses highlights the need for pan-coronavirus interventions for effective pandemic ...
N. Johnson, Steven C. Wall, Kevin J. Kramer, Clinton M. Holt, S. Periasamy, S. Richardson, Naveenchandra Suryadevara, Emanuele Andreano, Ida Paciello, Giulio Pierleoni, G. Piccini, Ying Huang, Pan Ge, James D. Allen, Naoko Uno, Andrea R. Shiakolas, Kelsey A. Pilewski, Rachel S. Nargi, Rachel E. Sutton, Alexandra A. Abu-Shmais, Robert Parks, B. Haynes, Robert H. Carnahan, James E. Crowe, E. Montomoli, R. Rappuoli, A. Bukreyev, Ted M. Ross, G. Sautto, Jason S. McLellan, Ivelin S. Georgiev   +30 more
semanticscholar   +7 more sources

Genome-scale CRISPR screen identifies TMEM198 driving double membrane vesicle formation in swine alphacoronavirus and murine betacoronavirus infected cells

PLoS Pathogens
COVID-19 pandemic caused by the SARS-CoV-2 which is well-publicized cross-species transmissibility. SARS-CoV-2 belongs to genus Betacoronavirus, several pathogenic alphacoronaviruses have shown similar patterns of emergence.
Lei Shi, Yu Zhang, Yue-Yue Duan, Mao-Wen Sun, Cong Yuan, Li-Yan Cao, Xiang-Yu Kong, Wen-Long Zhang, Hai-Xue Zheng, Qi Wang   +9 more
semanticscholar   +2 more sources

Cell surface nucleocapsid protein expression: A betacoronavirus immunomodulatory strategy

Proceedings of the National Academy of Sciences, 2023
Significance Despite the unprecedented global response to the COVID-19 pandemic, critical aspects of HCoV pathogenesis remain unclear, including mechanisms underlying immune evasion and viral manipulation of the cytokine network.
Alberto Domingo López-Muñoz, Jefferson J. S. Santos, J. Yewdell   +2 more
semanticscholar   +5 more sources

Phylogenetic analysis of the betacoronavirus S1 subunit [PDF]

F1000Research, 2020
The ongoing pandemic outbreak of coronavirus disease 2019 (COVID-19) has been caused by the new betacoronavirus (BetaCoV) severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). Together with other epidemic outbreaks of BetaCoV infectious diseases (Severe Acute Respiratory Syndrome (SARS) in 2002-2003 in China and Middle East Respiratory ...
Zyrianova Irina
openaire   +2 more sources