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EClinicalMedicine, 2021 Background: Of the three lethal coronaviruses, in addition to the ongoing pandemic-causing SARS-CoV 2, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) remains in circulation. Information on MERS-CoV has relied on small sample of patients.
Andrew D Maher, Shahul Ebrahim
exaly +3 more sources
MERS-CoV spike nanoparticles protect mice from MERS-CoV infection
Vaccine, 2017 The Middle East respiratory syndrome coronavirus (MERS-CoV) was first discovered in late 2012 and has gone on to cause over 1800 infections and 650 deaths. There are currently no approved therapeutics or vaccinations for MERS-CoV. The MERS-CoV spike (S) protein is responsible for receptor binding and virion entry to cells, is immunodominant and induces
Gregory Glenn +2 more
exaly +3 more sources
On-site detection of MERS-CoV infections in a camel slaughterhouse in Kenya using a commercial rapid antigen test [PDF]
Frontiers in Veterinary ScienceBackgroundMiddle East respiratory syndrome coronavirus (MERS-CoV) poses a significant public health risk, with dromedary camels being the primary reservoir hosts.
Brian Maina Ogoti +26 more
doaj +2 more sources
Colostrum from MERS-CoV seropositive camels for MERS prophylaxis and SARS-CoV-2 infection, a placebo controlled randomized trial [PDF]
Scientific ReportsCOVID-19 pandemic is currently relatively controlled, mainly due to effective vaccines. Preparedness for future outbreaks should include means for reducing transmission of SARS-CoV-2 and other coronaviruses like MERS-CoV.
Hagit Masika +22 more
doaj +2 more sources
Immunogenicity and protective efficacy of MERS CoV, NL140422, and HKU4 spike protein nanoparticle vaccines [PDF]
npj VirusesWhile vaccines against Middle East respiratory syndrome coronavirus (MERS-CoV) have had substantial preclinical and clinical development, few vaccine candidates target other related viruses with potential for human spillover within the Merbecovirus ...
Peter J. Halfmann +5 more
doaj +2 more sources
Development of Small-Molecule MERS-CoV Inhibitors
Viruses, 2018 Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV
Fei Yu, Jiang Shibo, Naru Zhang
exaly +3 more sources
Glycosylated Receptor-Binding-Domain-Targeting Mucosal Vaccines Protect Against SARS-CoV-2 Omicron and MERS-CoV [PDF]
VaccinesBackground. The pathogenic coronaviruses (CoVs) MERS-CoV and SARS-CoV-2, which are responsible for the MERS outbreak and the COVID-19 pandemic, respectively, continue to infect humans, with significant adverse outcomes.
Xiaoqing Guan +6 more
doaj +2 more sources
, 2019 About the Special Issue Editors Fang Li is an Associate Professor in the Department of Veterinary and Biomedical Sciences at the University of Minnesota. His main line of research examines the invasion mechanisms of viruses. Specifically, his group investigates the structures and functions of virus-surface proteins that mediate receptor recognition and
Du, Lanying, Li, Fang
+6 more sources
Impact of MERS-CoV and SARS-CoV-2 Viral Infection on Immunoglobulin-IgG Cross-Reactivity
Vaccines, 2023 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has posed a considerable threat to public health and global economies. SARS-CoV-2 has largely affected a vast world population and was declared a COVID-19 pandemic outbreak, with a substantial ...
Joud Mohammed AlKhalifah +7 more
doaj +1 more source
Infectious Microbes & Diseases, 2022 . Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans has a high mortality of >30%. Dromedaries are the reservoir of MERS-CoV and the main source of human infections.
Susanna Kar-Pui Lau +7 more
doaj +1 more source