Results 1 to 10 of about 51,213 (158)

Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field

Viruses, 2022
Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on ...
Aurelio Bonavia, Samuel R. Dominguez, Gabriela Dveksler, Sara Gagneten, Megan Howard, Scott Jeffers, Zhaohui Qian, Mary Kathryn Smith, Larissa B. Thackray, Dina B. Tresnan, David E. Wentworth, David R. Wessner, Richard K. Williams, Tanya A. Miura   +13 more
doaj   +1 more source

CD4+ T Cells of Prostate Cancer Patients Have Decreased Immune Responses to Antigens Derived From SARS-CoV-2 Spike Glycoprotein

Frontiers in Immunology, 2021
The adaptive immune response to severe acute respiratory coronavirus 2 (SARS-CoV-2) is important for vaccine development and in the recovery from coronavirus disease 2019 (COVID-19).
Pavla Taborska, Zuzana Strizova, Dmitry Stakheev, Ludek Sojka, Ludek Sojka, Jirina Bartunkova, Daniel Smrz   +6 more
doaj   +1 more source

A bioinformatic analysis of the spike glycoprotein & evolution of COVID-19

Medicine Science, 2022
The Severe Acute Respiratory Syndrome 2 (COVID-19/SARS-CoV-2) has become the pandemic of the century due to its drastically infectious nature. SARS & MERS are the most notable of past coronaviruses infecting merely thousands compared to COVID-19’s ...
Atiksh Chandra, Sathees B Chandra
doaj   +1 more source

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2

Scientific Reports, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a newly-discovered coronavirus and responsible for the spread of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infected millions of people in the world and immediately became a pandemic in
Farzaneh Jafary, Sepideh Jafari, Mohamad Reza Ganjalikhany   +2 more
doaj   +1 more source

SARS‐CoV‐2 spike glycoprotein‐reactive T cells can be readily expanded from COVID‐19 vaccinated donors

Immunity, Inflammation and Disease, 2021
Introduction The COVID‐19 vaccine was designed to provide protection against infection by the severe respiratory coronavirus 2 (SARS‐CoV‐2) and coronavirus disease 2019 (COVID‐19).
Pavla Taborska, Jan Lastovicka, Dmitry Stakheev, Zuzana Strizova, Jirina Bartunkova, Daniel Smrz   +5 more
doaj   +1 more source

The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in China

Frontiers in Veterinary Science, 2021
Swine acute diarrhea syndrome (SADS) is a highly contagious infectious disease characterized by acute vomiting and watery diarrhea in neonatal piglets.
Yan-Yan Guo, Pei-Hua Wang, Yuan-Qing Pan, Rui-Zhu Shi, Ya-Qian Li, Fan Guo, Li Xing, Li Xing, Li Xing   +8 more
doaj   +1 more source

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

Viruses, 2021
The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells.
Eun Jeong Park, Phyoe Kyawe Myint, Michael Gyasi Appiah, Samuel Darkwah, Siqingaowa Caidengbate, Atsushi Ito, Eri Matsuo, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +9 more
doaj   +1 more source

Genetic Variant of SARS-CoV-2 Isolates in Indonesia: Spike Glycoprotein Gene

Journal of Pure and Applied Microbiology, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus and the primary causative agent of coronavirus disease 2019 (COVID-19), first occurred in China and rapidly spread worldwide.
Arif Nur Muhammad Ansori, Viol Dhea Kharisma, Sahal Sabilil Muttaqin, Yulanda Antonius, Arli Aditya Parikesit   +4 more
doaj   +1 more source

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming

Molecules, 2020
Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2′) cleavage sites that are processed by human host proteases.
Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin, Maurizio Pellecchia   +5 more
doaj   +1 more source

In silico Identification of Characteristics Spike Glycoprotein of SARS-CoV-2 in the Development Novel Candidates for COVID-19 Infectious Diseases

Journal of Biomedicine and Translational Research, 2020
Background: The emergence of infectious diseases caused by SARS-CoV-2 has resulted in more than 90,000 infections and 3,000 deaths. The coronavirus spike glycoprotein encourages the entry of SARS-CoV-2 into cells and is the main target of antivirals ...
Taufik Muhammad Fakih, Mentari Luthfika Dewi   +1 more
doaj   +1 more source