Results 1 to 10 of about 40,476 (180)

Concanavalin A targets phylogenetically conserved N-linked glycans on coronavirus spike proteins for broad-spectrum antiviral activity [PDF]

Journal of Virology
The rapid evolution of SARS-CoV-2 variants, driven by antigenic drift in the spike glycoprotein, continues to undermine the efficacy of current vaccines and monoclonal antibody therapies. Targeting conserved features of the spike protein has been a major
Dekuan Guo, Shi Yu, Kaixiong Ma, Hua Tao, Qingxing Wang, Sirui Han, Qiangyun Ai, Huina Hu, Xiancai Ma, Geng Li, Shaobo Wang   +10 more
doaj   +2 more sources

Ligand-Based Pharmacophore Modeling and Structure-Based Virtual Screening for Identifying Potential Therapeutic Agents Targeting the SARS-CoV-2 Spike Protein-ACE2 Receptor Interaction. [PDF]

ChemMedChem
A protocol guided by ligand‐based pharmacophore modeling and structure‐based virtual screening enabled the identification of 1H‐pyrazol‐5‐ol derivatives as novel inhibitors of the SARS‐CoV‐2 spike protein. The lead inhibitors, C‐3 and C‐4, could serve as templates for the design of potent antiviral agents targeting viral entry into host cells ...
Delgado-Maldonado T, Vargas-Salas G, Bandyopadhyay D, Moreno-Rodríguez A, Ortiz-Pérez E, Rivera G.   +5 more
europepmc   +2 more sources

Widespread SARS-CoV-2 Transmission Despite Limited Reported Cases and Clinical Disease: Exploring the Role of Pre-Existing Humoral Immunity to SARS-CoV-2 in Eastern Sierra Leone. [PDF]

Immun Inflamm Dis
ABSTRACT Background Since December 2019, SARS‐CoV‐2 has infected over 700 million people and caused > 7 million deaths. While much of the global north was severely affected, sub‐Saharan Africa was relatively spared. Possible reasons include a younger population, fewer comorbidities, and pre‐existing immunity.
Samuels RJ, Bond NG, Sumah I, Grant DS, Kamara MS, Bazzano L, Fernandez C, Borrega R, Chandra S, Glezer CR, Schieffelin JS, Moon TD.   +11 more
europepmc   +2 more sources

Emerging COVID-19 coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26

Emerging Microbes and Infections, 2020
The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free ...
Naveen Vankadari, Jacqueline A Wilce
exaly   +3 more sources

Kathryn V. Holmes: A Career of Contributions to the Coronavirus Field

Viruses, 2022
Over the past two years, scientific research has moved at an unprecedented rate in response to the COVID-19 pandemic. The rapid development of effective vaccines and therapeutics would not have been possible without extensive background knowledge on ...
Aurelio Bonavia, Samuel R. Dominguez, Gabriela Dveksler, Sara Gagneten, Megan Howard, Scott Jeffers, Zhaohui Qian, Mary Kathryn Smith, Larissa B. Thackray, Dina B. Tresnan, David E. Wentworth, David R. Wessner, Richard K. Williams, Tanya A. Miura   +13 more
doaj   +1 more source

CD4+ T Cells of Prostate Cancer Patients Have Decreased Immune Responses to Antigens Derived From SARS-CoV-2 Spike Glycoprotein

Frontiers in Immunology, 2021
The adaptive immune response to severe acute respiratory coronavirus 2 (SARS-CoV-2) is important for vaccine development and in the recovery from coronavirus disease 2019 (COVID-19).
Pavla Taborska, Zuzana Strizova, Dmitry Stakheev, Ludek Sojka, Ludek Sojka, Jirina Bartunkova, Daniel Smrz   +6 more
doaj   +1 more source

A bioinformatic analysis of the spike glycoprotein & evolution of COVID-19

Medicine Science, 2022
The Severe Acute Respiratory Syndrome 2 (COVID-19/SARS-CoV-2) has become the pandemic of the century due to its drastically infectious nature. SARS & MERS are the most notable of past coronaviruses infecting merely thousands compared to COVID-19’s ...
Atiksh Chandra, Sathees B Chandra
doaj   +1 more source

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2

Scientific Reports, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a newly-discovered coronavirus and responsible for the spread of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infected millions of people in the world and immediately became a pandemic in
Farzaneh Jafary, Sepideh Jafari, Mohamad Reza Ganjalikhany   +2 more
doaj   +1 more source

SARS‐CoV‐2 spike glycoprotein‐reactive T cells can be readily expanded from COVID‐19 vaccinated donors

Immunity, Inflammation and Disease, 2021
Introduction The COVID‐19 vaccine was designed to provide protection against infection by the severe respiratory coronavirus 2 (SARS‐CoV‐2) and coronavirus disease 2019 (COVID‐19).
Pavla Taborska, Jan Lastovicka, Dmitry Stakheev, Zuzana Strizova, Jirina Bartunkova, Daniel Smrz   +5 more
doaj   +1 more source

The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in China

Frontiers in Veterinary Science, 2021
Swine acute diarrhea syndrome (SADS) is a highly contagious infectious disease characterized by acute vomiting and watery diarrhea in neonatal piglets.
Yan-Yan Guo, Pei-Hua Wang, Yuan-Qing Pan, Rui-Zhu Shi, Ya-Qian Li, Fan Guo, Li Xing, Li Xing, Li Xing   +8 more
doaj   +1 more source