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The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics [PDF]
Current Research in Neurobiology, 2023 SARS-CoV-2 infection is associated with both acute and post-acute neurological symptoms. Emerging evidence suggests that SARS-CoV-2 can alter mitochondrial metabolism, suggesting that changes in brain metabolism may contribute to the development of acute
Chantal A. Pileggi +9 more
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Mechanistic insights into ligand dissociation from the SARS-CoV-2 spike glycoprotein. [PDF]
PLoS Computational BiologyThe COVID-19 pandemic, driven by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred an urgent need for effective therapeutic interventions.
Timothy Hasse +6 more
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Emerging Microbes and Infections, 2020 The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free ...
Naveen Vankadari, Jacqueline Wilce
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Spike Glycoprotein-Mediated Entry of SARS Coronaviruses
Viruses, 2020 Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses and causes of epidemic diseases that have resulted in public health emergencies worldwide. Angiotensin-converting enzyme 2 (
Ye Xiang
exaly +3 more sources
Molecules, 2020 The worldwide health emergency of the SARS-CoV-2 pandemic and the absence of a specific treatment for this new coronavirus have led to the use of computational strategies (drug repositioning) to search for treatments.
Jazmin García-Machorro +2 more
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A bioinformatic analysis of the spike glycoprotein & evolution of COVID-19
Medicine Science, 2022 The Severe Acute Respiratory Syndrome 2 (COVID-19/SARS-CoV-2) has become the pandemic of the century due to its drastically infectious nature. SARS & MERS are the most notable of past coronaviruses infecting merely thousands compared to COVID-19s ...
Atiksh Chandra, Sathees B Chandra
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Frontiers in Veterinary Science, 2021 Swine acute diarrhea syndrome (SADS) is a highly contagious infectious disease characterized by acute vomiting and watery diarrhea in neonatal piglets.
Yan-Yan Guo +8 more
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ACE2 overexpressing mesenchymal stem cells alleviates COVID-19 lung injury by inhibiting pyroptosis
iScience, 2022 Summary: Mesenchymal stem cells (MSCs) have shown some efficacy in the COVID-19 treatment. We proposed that exogenous supplementation of ACE2 via MSCs (ACE2-MSCs) might have better therapeutic effects.
Jinhuan Wei +7 more
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Association of Clinical Features with Spike Glycoprotein Mutations in Iranian COVID-19 Patients [PDF]
Journal of Clinical Medicine, 2022 Atefeh Zarepour +2 more
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Immunity, Inflammation and Disease, 2021 Introduction The COVID‐19 vaccine was designed to provide protection against infection by the severe respiratory coronavirus 2 (SARS‐CoV‐2) and coronavirus disease 2019 (COVID‐19).
Pavla Taborska +5 more
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