Results 1 to 10 of about 97,441 (133)

The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics [PDF]

Current Research in Neurobiology, 2023
SARS-CoV-2 infection is associated with both acute and post-acute neurological symptoms. Emerging evidence suggests that SARS-CoV-2 can alter mitochondrial metabolism, suggesting that changes in brain metabolism may contribute to the development of acute
Chantal A. Pileggi, Gaganvir Parmar, Hussein Elkhatib, Corina M. Stewart, Irina Alecu, Marceline Côté, Steffany A.L. Bennett, Jagdeep K. Sandhu, Miroslava Cuperlovic-Culf, Mary-Ellen Harper   +9 more
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Mechanistic insights into ligand dissociation from the SARS-CoV-2 spike glycoprotein. [PDF]

PLoS Computational Biology
The COVID-19 pandemic, driven by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred an urgent need for effective therapeutic interventions.
Timothy Hasse, Esra Mantei, Rezvan Shahoei, Shristi Pawnikar, Jinan Wang, Yinglong Miao, Yu-Ming M Huang   +6 more
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A bioinformatic analysis of the spike glycoprotein & evolution of COVID-19

Medicine Science, 2022
The Severe Acute Respiratory Syndrome 2 (COVID-19/SARS-CoV-2) has become the pandemic of the century due to its drastically infectious nature. SARS & MERS are the most notable of past coronaviruses infecting merely thousands compared to COVID-19’s ...
Atiksh Chandra, Sathees B Chandra
doaj   +1 more source

The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in China

Frontiers in Veterinary Science, 2021
Swine acute diarrhea syndrome (SADS) is a highly contagious infectious disease characterized by acute vomiting and watery diarrhea in neonatal piglets.
Yan-Yan Guo, Pei-Hua Wang, Yuan-Qing Pan, Rui-Zhu Shi, Ya-Qian Li, Fan Guo, Li Xing, Li Xing, Li Xing   +8 more
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ACE2 overexpressing mesenchymal stem cells alleviates COVID-19 lung injury by inhibiting pyroptosis

iScience, 2022
Summary: Mesenchymal stem cells (MSCs) have shown some efficacy in the COVID-19 treatment. We proposed that exogenous supplementation of ACE2 via MSCs (ACE2-MSCs) might have better therapeutic effects.
Jinhuan Wei, Rui Shang, Jiaqi Wang, Shengze Zhu, JianQiang Yin, Ying Chen, Yayu Zhao, Gang Chen   +7 more
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SARS‐CoV‐2 spike glycoprotein‐reactive T cells can be readily expanded from COVID‐19 vaccinated donors

Immunity, Inflammation and Disease, 2021
Introduction The COVID‐19 vaccine was designed to provide protection against infection by the severe respiratory coronavirus 2 (SARS‐CoV‐2) and coronavirus disease 2019 (COVID‐19).
Pavla Taborska, Jan Lastovicka, Dmitry Stakheev, Zuzana Strizova, Jirina Bartunkova, Daniel Smrz   +5 more
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The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus

Informatics in Medicine Unlocked, 2021
Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for treatment of patients with the COVID-19 disease.
Draško Tomić, Davor Davidović, Attila Marcel Szasz, Melinda Rezeli, Boris Pirkić, Jozsef Petrik, Vesna Bačić Vrca, Vladimir Janđel, Tomislav Lipić, Karolj Skala, Josip Mesarić, Marija Milković Periša, Zorislav Šojat, Branka Medved Rogina   +13 more
doaj   +1 more source

In silico Identification of Characteristics Spike Glycoprotein of SARS-CoV-2 in the Development Novel Candidates for COVID-19 Infectious Diseases

Journal of Biomedicine and Translational Research, 2020
Background: The emergence of infectious diseases caused by SARS-CoV-2 has resulted in more than 90,000 infections and 3,000 deaths. The coronavirus spike glycoprotein encourages the entry of SARS-CoV-2 into cells and is the main target of antivirals ...
Taufik Muhammad Fakih, Mentari Luthfika Dewi   +1 more
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Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro

Frontiers in Immunology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiates infection by attachment of the surface-exposed spike glycoprotein to the host cell receptors.
Preeti Vishwakarma, Naveen Yadav, Zaigham Abbas Rizvi, Naseem Ahmed Khan, Adarsh Kumar Chiranjivi, Shailendra Mani, Manish Bansal, Prabhanjan Dwivedi, Tripti Shrivastava, Rajesh Kumar, Amit Awasthi, Shubbir Ahmed, Sweety Samal   +12 more
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Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response

BMJ Open Respiratory Research, 2021
Objective To determine clinical and ethnodemographic correlates of serological responses against the SARS-CoV-2 spike glycoprotein following mild-to-moderate COVID-19.Design A retrospective cohort study of healthcare workers who had self-isolated due to ...
Saly Al-Taei, Sian E Faustini, Marisol Perez-Toledo, Sian Jossi, Joel D Allen, Claire Backhouse, Daniel Ebanks, Beena Emmanuel, Mark Garvey, Golaleh McGinnell, Yasunori Watanabe, Max Crispin, David C Wraith, Adam F Cunningham, Mark T Drayson, Alex G Richter, Adrian M Shields, Lynsey A Dunbar, Aduragbemi A Faniyi, Annabel Grinbergs, Joanne O'Neill   +20 more
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