Results 21 to 30 of about 97,509 (188)

Heme binding to the SARS-CoV-2 spike glycoprotein. [PDF]

J Biol Chem, 2023
No description ...
Freeman SL, Oliveira ASF, Gallio AE, Rosa A, Simitakou MK, Arthur CJ, Mulholland AJ, Cherepanov P, Raven EL.   +8 more
europepmc   +4 more sources

Coronaviruses spike glycoprotein endodomains: The sequence and structure-based comprehensive study. [PDF]

Protein Sci, 2023
AbstractThe flexibility of proteins makes them available to interact with many biomolecules in the cell. Specifically, such interactions in viruses help them to perform more functions despite having a smaller genome. Therefore, these flexible regions can be exciting and essential targets to be explored for their role in pathogenicity and therapeutic ...
Kumar P, Bhardwaj A, Mukherjee B, Joshi R, Giri R.   +4 more
europepmc   +4 more sources

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation [PDF]

Nature Structural & Molecular Biology, 2020
AbstractThe coronavirus (CoV) viral host cell fusion spike (S) protein is the primary immunogenic target for virus neutralization and the current focus of many vaccine design efforts. The highly flexible S-protein, with its mobile domains, presents a moving target to the immune system.
Rory Henderson, Robert J Edwards, Katayoun Mansouri, Katarzyna Janowska, Victoria Stalls, Sophie Gobeil, Megan Kopp, Allen Hsu, Mario Borgnia, Rob Parks, Barton F. Haynes, Priyamvada Acharya   +11 more
openaire   +4 more sources

Evolutionary dynamics of indels in SARS-CoV-2 spike glycoprotein [PDF]

Evolutionary Bioinformatics, 2021
AbstractSARS-CoV-2, responsible for the current COVID-19 pandemic that claimed over 4.2 million lives, belongs to a class of enveloped viruses that undergo quick evolutionary adjustments under selection pressure. Numerous variants have emerged in SARS-CoV-2 that are currently posing a serious challenge to the global vaccination effort and COVID-19 ...
R. Shyama Prasad Rao, Nagib Ahsan, Chunhui Xu, Lingtao Su, Jacob Verburgt, Luca Fornelli, Daisuke Kihara, Dong Xu   +7 more
openaire   +4 more sources

Closing coronavirus spike glycoproteins by structure-guided design [PDF]

, 2020
The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface, determining host and tissue tropism, and fusion of the viral and ...
McCallum, Matthew, Walls, Alexandra C., Corti, Davide, Veesler, David   +3 more
openaire   +2 more sources

Chasing COVID-19 through SARS-CoV-2 spike glycoprotein [PDF]

VirusDisease, 2020
An ongoing pandemic Coronavirus disease (COVID-19), caused by a newly emerged Coronavirus, SARS-CoV-2 has affected millions of people globally. One of the most crucial structural proteins of SARS-CoV-2 is the Spike glycoprotein (S-glycoprotein), for which the first de novo modelling was envisaged by our group in early 2020, and was superimposed to its ...
Saxena, Shailendra K., Kumar, Swatantra, Baxi, Preeti, Srivastava, Nishant, Puri, Bipin, Ratho, R. K.   +5 more
openaire   +2 more sources

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2

Scientific Reports, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a newly-discovered coronavirus and responsible for the spread of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infected millions of people in the world and immediately became a pandemic in
Farzaneh Jafary, Sepideh Jafari, Mohamad Reza Ganjalikhany   +2 more
doaj   +1 more source

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

Viruses, 2021
The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells.
Eun Jeong Park, Phyoe Kyawe Myint, Michael Gyasi Appiah, Samuel Darkwah, Siqingaowa Caidengbate, Atsushi Ito, Eri Matsuo, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +9 more
doaj   +1 more source

Optimized pseudotyping conditions for the SARS-COV2 Spike glycoprotein [PDF]

Journal of Virology, 2020
AbstractThe SARS-COV2 Spike glycoprotein is solely responsible for binding to the host cell receptor and facilitating fusion between the viral and host membranes. The ability to generate viral particles pseudotyped with SARS-COV2 Spike is useful for many types of studies, such as characterization of neutralizing antibodies or development of fusion ...
Johnson, Marc C., Lyddon, Terri D., Suarez, Reinier, Salcedo, Braxton, LePique, Mary, Graham, Maddie, Ricana, Clifton, Robinson, Carolyn, Ritter, Detlef G.   +8 more
openaire   +2 more sources

Glycoprotein molecular dynamics analysis: SARS-CoV-2 spike glycoprotein case study

, 2022
Molecular Dynamics (MD) is a method used to calculate the movement of atoms and molecules broadly applied to several aspects of science. It involves computational simulation, which makes it, at first glance, not easily accessible. The rise of several automated tools to perform molecular simulations has allowed researchers to navigate through the ...
Coutinho, João Victor Paccini, Macedo-da-Silva, Janaina, Mule, Simon Ngao, Kronenberger, Thales, Rosa-Fernandes, Livia, Wrenger, Carsten, Palmisano, Giuseppe   +6 more
openaire   +2 more sources