Results 21 to 30 of about 76,288 (243)

Evolutionary dynamics of indels in SARS-CoV-2 spike glycoprotein [PDF]

Evolutionary Bioinformatics, 2021
Abstract SARS-CoV-2, responsible for the current COVID-19 pandemic that claimed over 4.2 million lives, belongs to a class of enveloped viruses that undergo quick evolutionary adjustments under selection pressure. Numerous variants have emerged in SARS-CoV-2 that are currently posing a serious challenge to the global vaccination effort ...
R. Shyama Prasad Rao, Nagib Ahsan, Chunhui Xu, Lingtao Su, Jacob Verburgt, Luca Fornelli, Daisuke Kihara, Dong Xu   +7 more
openaire   +4 more sources

Molecular organization of the New World arenavirus spike glycoprotein complex. [PDF]

Nat Microbiol
Abstract Of the multiple arenaviruses that cause haemorrhagic fevers in the Americas, all lack reliable therapeutic options, and only one has a vaccine. The arenavirus glycoprotein complex (GPC) binds cellular receptors and mediates pH-dependent fusion of viral and host cell membranes during entry.
Mann CJ, Yang P, Olal D, Fan X, Smith KN, Clark LE, Krammer F, Bian Y, Abraham J.   +8 more
europepmc   +3 more sources

Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions [PDF]

Viruses, 2015
The envelopes of coronaviruses (CoVs) contain primarily three proteins; the two major glycoproteins spike (S) and membrane (M), and envelope (E), a non-glycosylated protein. Unlike other enveloped viruses, CoVs bud and assemble at the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC).
Makoto Ujike, Fumihiro Taguchi
openaire   +3 more sources

In silico Identification of Characteristics Spike Glycoprotein of SARS-CoV-2 in the Development Novel Candidates for COVID-19 Infectious Diseases

Journal of Biomedicine and Translational Research, 2020
Background: The emergence of infectious diseases caused by SARS-CoV-2 has resulted in more than 90,000 infections and 3,000 deaths. The coronavirus spike glycoprotein encourages the entry of SARS-CoV-2 into cells and is the main target of antivirals ...
Taufik Muhammad Fakih, Mentari Luthfika Dewi   +1 more
doaj   +1 more source

Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro

Frontiers in Immunology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiates infection by attachment of the surface-exposed spike glycoprotein to the host cell receptors.
Preeti Vishwakarma, Naveen Yadav, Zaigham Abbas Rizvi, Naseem Ahmed Khan, Adarsh Kumar Chiranjivi, Shailendra Mani, Manish Bansal, Prabhanjan Dwivedi, Tripti Shrivastava, Rajesh Kumar, Amit Awasthi, Shubbir Ahmed, Sweety Samal   +12 more
doaj   +1 more source

Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response

BMJ Open Respiratory Research, 2021
Objective To determine clinical and ethnodemographic correlates of serological responses against the SARS-CoV-2 spike glycoprotein following mild-to-moderate COVID-19.Design A retrospective cohort study of healthcare workers who had self-isolated due to ...
Saly Al-Taei, Sian E Faustini, Marisol Perez-Toledo, Sian Jossi, Joel D Allen, Claire Backhouse, Daniel Ebanks, Beena Emmanuel, Mark Garvey, Golaleh McGinnell, Yasunori Watanabe, Max Crispin, David C Wraith, Adam F Cunningham, Mark T Drayson, Alex G Richter, Adrian M Shields, Lynsey A Dunbar, Aduragbemi A Faniyi, Annabel Grinbergs, Joanne O'Neill   +20 more
doaj   +1 more source

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2

Scientific Reports, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a newly-discovered coronavirus and responsible for the spread of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infected millions of people in the world and immediately became a pandemic in
Farzaneh Jafary, Sepideh Jafari, Mohamad Reza Ganjalikhany   +2 more
doaj   +1 more source

Location of the Spike Glycoproteins in the Semliki Forest Virus Membrane [PDF]

Proceedings of the National Academy of Sciences, 1974
Labeling experiments with formyl-[ 35 S]-methionyl sulfone methylphosphate and crosslinking studies with dimethylsuberimidate suggest that the spike glycoproteins of Semliki Forest virus extend through the viral membrane into close contact with the nucleocapsid.
H, Garoff, K, Simons
openaire   +2 more sources

Optimized pseudotyping conditions for the SARS-COV2 Spike glycoprotein [PDF]

Journal of Virology, 2020
Abstract The SARS-COV2 Spike glycoprotein is solely responsible for binding to the host cell receptor and facilitating fusion between the viral and host membranes. The ability to generate viral particles pseudotyped with SARS-COV2 Spike is useful for many types of studies, such as characterization of neutralizing ...
Johnson, Marc C., Lyddon, Terri D., Suarez, Reinier, Salcedo, Braxton, LePique, Mary, Graham, Maddie, Ricana, Clifton, Robinson, Carolyn, Ritter, Detlef G.   +8 more
openaire   +2 more sources

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

Viruses, 2021
The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells.
Eun Jeong Park, Phyoe Kyawe Myint, Michael Gyasi Appiah, Samuel Darkwah, Siqingaowa Caidengbate, Atsushi Ito, Eri Matsuo, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +9 more
doaj   +1 more source