Results 21 to 30 of about 73,847 (203)

Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein. [PDF]

Nat Commun, 2023
Abstract SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 receptor, and an open state that does so but displays more exposed antigenic surface.
Calvaresi V, Wrobel AG, Toporowska J, Hammerschmid D, Doores KJ, Bradshaw RT, Parsons RB, Benton DJ, Roustan C, Reading E, Malim MH, Gamblin SJ, Politis A.   +12 more
europepmc   +7 more sources

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2

Scientific Reports, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a newly-discovered coronavirus and responsible for the spread of coronavirus disease 2019 (COVID-19). SARS-CoV-2 infected millions of people in the world and immediately became a pandemic in
Farzaneh Jafary, Sepideh Jafari, Mohamad Reza Ganjalikhany   +2 more
doaj   +1 more source

Molecular organization of the New World arenavirus spike glycoprotein complex. [PDF]

Nat Microbiol
Abstract Of the multiple arenaviruses that cause haemorrhagic fevers in the Americas, all lack reliable therapeutic options, and only one has a vaccine. The arenavirus glycoprotein complex (GPC) binds cellular receptors and mediates pH-dependent fusion of viral and host cell membranes during entry.
Mann CJ, Yang P, Olal D, Fan X, Smith KN, Clark LE, Krammer F, Bian Y, Abraham J.   +8 more
europepmc   +3 more sources

Location of the Spike Glycoproteins in the Semliki Forest Virus Membrane [PDF]

Proceedings of the National Academy of Sciences, 1974
Labeling experiments with formyl-[ 35 S]-methionyl sulfone methylphosphate and crosslinking studies with dimethylsuberimidate suggest that the spike glycoproteins of Semliki Forest virus extend through the viral membrane into close contact with the nucleocapsid.
H, Garoff, K, Simons
openaire   +2 more sources

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

Viruses, 2021
The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells.
Eun Jeong Park, Phyoe Kyawe Myint, Michael Gyasi Appiah, Samuel Darkwah, Siqingaowa Caidengbate, Atsushi Ito, Eri Matsuo, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +9 more
doaj   +1 more source

Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein [PDF]

, 2006
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) mediates attachment, receptor engagement and entry via its spike glycoprotein (S). S-dependent viral entry requires the presence of a primary receptor, angiotensin converting enzyme-2 (ACE2), while the C-type lectins, DC-SIGN, DC-SIGNR, and LSECtin act as attachment factors, promoting ...
Simmons, Graham, Rennekamp, Andrew J., Bates, Paul   +2 more
openaire   +2 more sources

Closing coronavirus spike glycoproteins by structure-guided design [PDF]

, 2020
The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface, determining host and tissue tropism, and fusion of the viral and ...
McCallum, Matthew, Walls, Alexandra C., Corti, Davide, Veesler, David   +3 more
openaire   +2 more sources

Optimized pseudotyping conditions for the SARS-COV2 Spike glycoprotein [PDF]

Journal of Virology, 2020
Abstract The SARS-COV2 Spike glycoprotein is solely responsible for binding to the host cell receptor and facilitating fusion between the viral and host membranes. The ability to generate viral particles pseudotyped with SARS-COV2 Spike is useful for many types of studies, such as characterization of neutralizing ...
Johnson, Marc C., Lyddon, Terri D., Suarez, Reinier, Salcedo, Braxton, LePique, Mary, Graham, Maddie, Ricana, Clifton, Robinson, Carolyn, Ritter, Detlef G.   +8 more
openaire   +2 more sources

SARS-CoV-2 Spike Expression at the Surface of Infected Primary Human Airway Epithelial Cells

Viruses, 2021
Different serological assays were rapidly generated to study humoral responses against the SARS-CoV-2 Spike glycoprotein. Due to the intrinsic difficulty of working with SARS-CoV-2 authentic virus, most serological assays use recombinant forms of the ...
Shilei Ding, Damien Adam, Guillaume Beaudoin-Bussières, Alexandra Tauzin, Shang Yu Gong, Romain Gasser, Annemarie Laumaea, Sai Priya Anand, Anik Privé, Catherine Bourassa, Halima Medjahed, Jérémie Prévost, Hugues Charest, Jonathan Richard, Emmanuelle Brochiero, Andrés Finzi   +15 more
doaj   +1 more source

Budding of Rabies Virus Particles in the Absence of the Spike Glycoprotein [PDF]

Cell, 1996
Budding of enveloped viruses from cellular membranes is believed to de pend on the presence of transmembrane spike proteins interacting with cytoplasmic virus components. To address the mechanism of rhabdovirus budding, we generated rabies virus mutants deficient for the glycoprotein G or the G cytoplasmic tail.
Mebatsion, Teshome, König, Matthias, Conzelmann, Karl-Klaus   +2 more
openaire   +2 more sources