Results 31 to 40 of about 76,288 (243)
Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein [PDF]
, 2006 Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) mediates attachment, receptor engagement and entry via its spike glycoprotein (S). S-dependent viral entry requires the presence of a primary receptor, angiotensin converting enzyme-2 (ACE2), while the C-type lectins, DC-SIGN, DC-SIGNR, and LSECtin act as attachment factors, promoting ...
Simmons, Graham +2 more
openaire +2 more sources
Closing coronavirus spike glycoproteins by structure-guided design [PDF]
, 2020 The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface, determining host and tissue tropism, and fusion of the viral and ...
McCallum, Matthew +3 more
openaire +2 more sources
SARS-CoV-2 Spike Expression at the Surface of Infected Primary Human Airway Epithelial Cells
Viruses, 2021 Different serological assays were rapidly generated to study humoral responses against the SARS-CoV-2 Spike glycoprotein. Due to the intrinsic difficulty of working with SARS-CoV-2 authentic virus, most serological assays use recombinant forms of the ...
Shilei Ding +15 more
doaj +1 more source
Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus [PDF]
Virologica Sinica, 2010 A group of SARS-like coronaviruses (SL-CoV) have been identified in horseshoe bats. Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental
Hou, Yu-xuan +5 more
openaire +2 more sources
Modeling the structure of SARS-CoV spike glycoprotein
, 2004 The S1 and S2 subunits of the spike glycoprotein of SARS-CoV coronavirus have been modelled, even though the corresponding amino acid sequences were not suitable for tertiary structure predictions with conventional homology and/or threading procedures ...
Ciutti A. +5 more
core +2 more sources
Expression of SARS-coronavirus spike glycoprotein in Pichia pastoris [PDF]
Virus Genes, 2008 To establish a rapid and economical method for the expression of viral proteins in high yield and purity by Pichia pastoris, the S protein of the SARS-CoV was selected in this study. Six S glycoprotein fragments were expressed in Escherichia coli BL21 and yeast KM71H strains.
Chuck, Chi-Pang +5 more
openaire +2 more sources
Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage [PDF]
, 2012 © 2012 Millet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Béatrice Nal +66 more
core +1 more source
Budding of Rabies Virus Particles in the Absence of the Spike Glycoprotein [PDF]
Cell, 1996 Budding of enveloped viruses from cellular membranes is believed to de pend on the presence of transmembrane spike proteins interacting with cytoplasmic virus components. To address the mechanism of rhabdovirus budding, we generated rabies virus mutants deficient for the glycoprotein G or the G cytoplasmic tail.
Mebatsion, Teshome +2 more
openaire +2 more sources
Nature Communications, 2021 The spike glycoprotein in coronaviruses is a key viral protein for cross-species transmission and infection. Here, the authors present the cryo-EM structures of the spike ectodomains from bat and pangolin coronaviruses, compare them with the available ...
Shuyuan Zhang +8 more
doaj +1 more source
F1000Research, 2021 Background: An immunoinformatic approach may be useful to investigate the conserved region in the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Indonesia isolates.
Fedik Abdul Rantam +7 more
doaj +1 more source