Results 31 to 40 of about 73,847 (203)

Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus [PDF]

Virologica Sinica, 2010
A group of SARS-like coronaviruses (SL-CoV) have been identified in horseshoe bats. Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental
Hou, Yu-xuan, Peng, Cheng, Han, Zheng-gang, Zhou, Peng, Chen, Ji-guo, Shi, Zheng-li   +5 more
openaire   +2 more sources

Expression of SARS-coronavirus spike glycoprotein in Pichia pastoris [PDF]

Virus Genes, 2008
To establish a rapid and economical method for the expression of viral proteins in high yield and purity by Pichia pastoris, the S protein of the SARS-CoV was selected in this study. Six S glycoprotein fragments were expressed in Escherichia coli BL21 and yeast KM71H strains.
Chuck, Chi-Pang, Wong, Chi-Hang, Chow, Larry Ming-Cheung, Fung, Kwok-Pui, Waye, Mary Miu-Yee, Tsui, Stephen Kwok-Wing   +5 more
openaire   +2 more sources

Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution

Nature Communications, 2021
The spike glycoprotein in coronaviruses is a key viral protein for cross-species transmission and infection. Here, the authors present the cryo-EM structures of the spike ectodomains from bat and pangolin coronaviruses, compare them with the available ...
Shuyuan Zhang, Shuyuan Qiao, Jinfang Yu, Jianwei Zeng, Sisi Shan, Long Tian, Jun Lan, Linqi Zhang, Xinquan Wang   +8 more
doaj   +1 more source

Molecular docking and dynamic simulation of conserved B cell epitope of SARS-CoV-2 glycoprotein Indonesian isolates: an immunoinformatic approach [version 1; peer review: 3 approved]

F1000Research, 2021
Background: An immunoinformatic approach may be useful to investigate the conserved region in the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Indonesia isolates.
Fedik Abdul Rantam, Viol Dhea Kharisma, Christrijogo Sumartono, Jusak Nugraha, Andi Yasmin Wijaya, Helen Susilowati, Suryo Kuncorojakti, Alexander Patera Nugraha   +7 more
doaj   +1 more source

Inhibitory potentials of ivermectin, nafamostat, and camostat on spike protein and some nonstructural proteins of SARS-CoV-2: Virtual screening approach

Jurnal Teknologi Laboratorium, 2022
The search for potent oral drugs either through synthetic routes or by drug repurposing for combating the dreaded covid-19 virus is still ongoing. The coronavirus spike glycoprotein and several other non-structural proteins play crucial roles in the ...
Haruna Isiyaku Umar, Ijeoma Akunna Duru, Uchechi Emmanuela Enenebeaku, Lynda Chioma Ngozi Olehi, Christian Ebere Enyoh, Chidi Edbert Duru   +5 more
doaj   +1 more source

Hunting for the SARS-CoV-2 Spike Glycoprotein Ancestor [PDF]

, 2020
Abstract Objective: In December 2019 a novel coronavirus (SARS-CoV-2) that is causing the current COVID-19 pandemic was identified in Wuhan, China. Many questions have been raised about its origin and adaptation to humans. In the present work we performed a genetic analysis of the Spike glycoprotein (S) of SARS-CoV-2 and other related ...
Alejandro Flores-Alanis, Luisa Sandner-Miranda, Gabriela Delgado, Alejandro Cravioto, Rosario Morales-Espinosa   +4 more
openaire   +1 more source

Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination

Nature Communications, 2023
The Spike glycoprotein of SARS-CoV-2 mediates viral entry into the host cell via the interaction between its receptor binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2). Spike RBD has been reported to adopt two primary conformations, a
Shawn B. Egri, Xue Wang, Marco A. Díaz-Salinas, Jeremy Luban, Natalya V. Dudkina, James B. Munro, Kuang Shen   +6 more
doaj   +1 more source

Conformational stability of SARS-CoV-2 glycoprotein spike variants

iScience, 2023
Summary: The severe acute respiratory syndrome spread worldwide, causing a pandemic. SARS-CoV-2 mutations have arisen in the spike, a glycoprotein at the viral envelope and an antigenic candidate for vaccines against COVID-19.
Hiam R.S. Arruda, Tulio M. Lima, Renata G.F. Alvim, Fernanda B.A. Victorio, Daniel P.B. Abreu, Federico F. Marsili, Karen D. Cruz, Mayra A. Marques, Patricia Sosa-Acosta, Mauricio Quinones-Vega, Jéssica de S. Guedes, Fábio C.S. Nogueira, Jerson L. Silva, Leda R. Castilho, Guilherme A.P. de Oliveira   +14 more
doaj   +1 more source

Characterization of spike glycoprotein of 2019-nCoV on virus entry and its immune cross-reactivity with spike glycoprotein of SARS-CoV [PDF]

, 2020
Abstract Since beginning of this century, there have already been three zoonotic outbreaks caused by beta coronaviruses (CoV), SARS-CoV in 2002-2003, MERS-CoV in 2012, and the newly identified 2019-nCoV in late 2019, Wuhan, China. As to Feb 10th, 2020, there are over 40,000 confirmed cases and over 900 deaths. However, little is known about the
Jin, Qi, Wang, Jianwei, Qian, Zhaohui, Ou, Xiuyuan, Liu, Yan, Lei, Xiaobo, Li, Pei, Mi, Dan, Ren, Lili, Guo, Li, Chen, Ting, Hu, Jiaxing, Xiang, Zichun, Mu, Zhixia, Chen, Xing, Chen, Jieyong, Hu, Keping   +16 more
openaire   +1 more source

Genetic Characteristics of Porcine Hemagglutinating Encephalomyelitis Coronavirus: Identification of Naturally Occurring Mutations Between 1970 and 2015

Frontiers in Microbiology, 2022
Porcine hemagglutinating encephalomyelitis virus (PHEV) is a Betacoronavirus characterized by neurological symptoms and a worldwide prevalence. Although PHEV is one of the earliest discovered porcine coronaviruses, it remains poorly studied.
Amina Nawal Bahoussi, Yan-Yan Guo, Rui-Zhu Shi, Pei-Hua Wang, Ya-Qian Li, Chang-Xin Wu, Chang-Xin Wu, Chang-Xin Wu, Li Xing, Li Xing, Li Xing   +10 more
doaj   +1 more source