Results 11 to 20 of about 97,509 (188)
Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike. [PDF]
PLoS Pathogens, 2013 The genus Orthobunyavirus within the family Bunyaviridae constitutes an expanding group of emerging viruses, which threaten human and animal health.
Thomas A Bowden +5 more
doaj +6 more sources
Emerging Microbes and Infections, 2020 The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free ...
Naveen Vankadari, Jacqueline A. Wilce
doaj +3 more sources
Conformational stability of SARS-CoV-2 glycoprotein spike variants
iScience, 2023 Summary: The severe acute respiratory syndrome spread worldwide, causing a pandemic. SARS-CoV-2 mutations have arisen in the spike, a glycoprotein at the viral envelope and an antigenic candidate for vaccines against COVID-19.
Hiam R.S. Arruda +14 more
doaj +3 more sources
Spike Glycoprotein-Mediated Entry of SARS Coronaviruses [PDF]
Viruses, 2020 Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are enveloped, positive-sense, single-stranded RNA viruses and causes of epidemic diseases that have resulted in public health emergencies worldwide. Angiotensin-converting enzyme 2 (
Lin Wang, Ye Xiang
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Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer [PDF]
Nature, 2016 The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few decades by two global outbreaks of deadly pneumonia. Entry of coronaviruses into cells is mediated by the transmembrane spike glycoprotein S, which forms a trimer carrying receptor-binding and membrane fusion functions.
Walls, Alexandra +7 more
openaire +7 more sources
Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein [PDF]
Cell, 2020 SUMMARYThe recent emergence of a novel coronavirus associated with an ongoing outbreak of pneumonia (Covid-2019) resulted in infections of more than 72,000 people and claimed over 1,800 lives. Coronavirus spike (S) glycoprotein trimers promote entry into cells and are the main target of the humoral immune response.
Walls, Alexandra +5 more
openaire +7 more sources
Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming [PDF]
Molecules, 2020 Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2′) cleavage sites that are processed by human host proteases.
Elisa Barile +5 more
doaj +3 more sources
Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein [PDF]
Nature Communications, 2020 Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.
Antoni G. Wrobel +8 more
doaj +4 more sources
The Human Leukocyte Antigen Class II Immunopeptidome of the SARS-CoV-2 Spike Glycoprotein
Cell Reports, 2020 Summary: Precise elucidation of the antigen sequences for T cell immunosurveillance greatly enhances our ability to understand and modulate humoral responses to viral infection or active immunization.
Michael D. Knierman +5 more
doaj +3 more sources
Cell-Free Glycoengineering of the Recombinant SARS-CoV-2 Spike Glycoprotein [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 The baculovirus-insect cell expression system is readily utilized to produce viral glycoproteins for research as well as for subunit vaccines and vaccine candidates, for instance against SARS-CoV-2 infections.
Johannes Ruhnau +10 more
doaj +5 more sources