Results 11 to 20 of about 73,847 (203)

Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike. [PDF]

PLoS Pathogens, 2013
The genus Orthobunyavirus within the family Bunyaviridae constitutes an expanding group of emerging viruses, which threaten human and animal health.
Thomas A Bowden, David Bitto, Angela McLees, Christelle Yeromonahos, Richard M Elliott, Juha T Huiskonen   +5 more
doaj   +6 more sources

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming [PDF]

Molecules, 2020
Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2′) cleavage sites that are processed by human host proteases.
Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin, Maurizio Pellecchia   +5 more
doaj   +3 more sources

Heme binding to the SARS-CoV-2 spike glycoprotein. [PDF]

J Biol Chem, 2023
No description ...
Freeman SL, Oliveira ASF, Gallio AE, Rosa A, Simitakou MK, Arthur CJ, Mulholland AJ, Cherepanov P, Raven EL.   +8 more
europepmc   +4 more sources

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation [PDF]

Nature Structural & Molecular Biology, 2020
Abstract The coronavirus (CoV) viral host cell fusion spike (S) protein is the primary immunogenic target for virus neutralization and the current focus of many vaccine design efforts. The highly flexible S-protein, with its mobile domains, presents a moving target to the immune system.
Rory Henderson, Robert J Edwards, Katayoun Mansouri, Katarzyna Janowska, Victoria Stalls, Sophie Gobeil, Megan Kopp, Allen Hsu, Mario Borgnia, Rob Parks, Barton F. Haynes, Priyamvada Acharya   +11 more
openaire   +4 more sources

Incorporation of Spike and Membrane Glycoproteins into Coronavirus Virions [PDF]

Viruses, 2015
The envelopes of coronaviruses (CoVs) contain primarily three proteins; the two major glycoproteins spike (S) and membrane (M), and envelope (E), a non-glycosylated protein. Unlike other enveloped viruses, CoVs bud and assemble at the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC).
Makoto Ujike, Fumihiro Taguchi
openaire   +3 more sources

Evolutionary dynamics of indels in SARS-CoV-2 spike glycoprotein [PDF]

Evolutionary Bioinformatics, 2021
Abstract SARS-CoV-2, responsible for the current COVID-19 pandemic that claimed over 4.2 million lives, belongs to a class of enveloped viruses that undergo quick evolutionary adjustments under selection pressure. Numerous variants have emerged in SARS-CoV-2 that are currently posing a serious challenge to the global vaccination effort ...
R. Shyama Prasad Rao, Nagib Ahsan, Chunhui Xu, Lingtao Su, Jacob Verburgt, Luca Fornelli, Daisuke Kihara, Dong Xu   +7 more
openaire   +4 more sources

The screening and evaluation of potential clinically significant HIV drug combinations against the SARS-CoV-2 virus

Informatics in Medicine Unlocked, 2021
Spike glycoprotein is essential for the reproduction of the SARS-CoV-2 virus, and its inhibition using already approved antiviral drugs may open new avenues for treatment of patients with the COVID-19 disease.
Draško Tomić, Davor Davidović, Attila Marcel Szasz, Melinda Rezeli, Boris Pirkić, Jozsef Petrik, Vesna Bačić Vrca, Vladimir Janđel, Tomislav Lipić, Karolj Skala, Josip Mesarić, Marija Milković Periša, Zorislav Šojat, Branka Medved Rogina   +13 more
doaj   +1 more source

In silico Identification of Characteristics Spike Glycoprotein of SARS-CoV-2 in the Development Novel Candidates for COVID-19 Infectious Diseases

Journal of Biomedicine and Translational Research, 2020
Background: The emergence of infectious diseases caused by SARS-CoV-2 has resulted in more than 90,000 infections and 3,000 deaths. The coronavirus spike glycoprotein encourages the entry of SARS-CoV-2 into cells and is the main target of antivirals ...
Taufik Muhammad Fakih, Mentari Luthfika Dewi   +1 more
doaj   +1 more source

Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro

Frontiers in Immunology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiates infection by attachment of the surface-exposed spike glycoprotein to the host cell receptors.
Preeti Vishwakarma, Naveen Yadav, Zaigham Abbas Rizvi, Naseem Ahmed Khan, Adarsh Kumar Chiranjivi, Shailendra Mani, Manish Bansal, Prabhanjan Dwivedi, Tripti Shrivastava, Rajesh Kumar, Amit Awasthi, Shubbir Ahmed, Sweety Samal   +12 more
doaj   +1 more source

Serological responses to SARS-CoV-2 following non-hospitalised infection: clinical and ethnodemographic features associated with the magnitude of the antibody response

BMJ Open Respiratory Research, 2021
Objective To determine clinical and ethnodemographic correlates of serological responses against the SARS-CoV-2 spike glycoprotein following mild-to-moderate COVID-19.Design A retrospective cohort study of healthcare workers who had self-isolated due to ...
Saly Al-Taei, Sian E Faustini, Marisol Perez-Toledo, Sian Jossi, Joel D Allen, Claire Backhouse, Daniel Ebanks, Beena Emmanuel, Mark Garvey, Golaleh McGinnell, Yasunori Watanabe, Max Crispin, David C Wraith, Adam F Cunningham, Mark T Drayson, Alex G Richter, Adrian M Shields, Lynsey A Dunbar, Aduragbemi A Faniyi, Annabel Grinbergs, Joanne O'Neill   +20 more
doaj   +1 more source