Results 11 to 20 of about 76,288 (243)

Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike. [PDF]

PLoS Pathogens, 2013
The genus Orthobunyavirus within the family Bunyaviridae constitutes an expanding group of emerging viruses, which threaten human and animal health.
Thomas A Bowden, David Bitto, Angela McLees, Christelle Yeromonahos, Richard M Elliott, Juha T Huiskonen   +5 more
doaj   +7 more sources

Conformational stability of SARS-CoV-2 glycoprotein spike variants

iScience, 2023
Summary: The severe acute respiratory syndrome spread worldwide, causing a pandemic. SARS-CoV-2 mutations have arisen in the spike, a glycoprotein at the viral envelope and an antigenic candidate for vaccines against COVID-19.
Hiam R.S. Arruda, Tulio M. Lima, Renata G.F. Alvim, Fernanda B.A. Victorio, Daniel P.B. Abreu, Federico F. Marsili, Karen D. Cruz, Mayra A. Marques, Patricia Sosa-Acosta, Mauricio Quinones-Vega, Jéssica de S. Guedes, Fábio C.S. Nogueira, Jerson L. Silva, Leda R. Castilho, Guilherme A.P. de Oliveira   +14 more
doaj   +4 more sources

Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein [PDF]

Nature Communications, 2020
Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.
Antoni G. Wrobel, Donald J. Benton, Saira Hussain, Ruth Harvey, Stephen R. Martin, Chloë Roustan, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin   +8 more
doaj   +5 more sources

Heme binding to the SARS-CoV-2 spike glycoprotein. [PDF]

J Biol Chem, 2023
The target for humoral immunity, SARS-CoV-2 spike glycoprotein has become the focus for vaccine research and development. Previous work demonstrated that the N-terminal domain (NTD) of SARS-CoV-2 spike binds biliverdin – a product of heme catabolism ...
Freeman SL, Oliveira ASF, Gallio AE, Rosa A, Simitakou MK, Arthur CJ, Mulholland AJ, Cherepanov P, Raven EL.   +8 more
europepmc   +5 more sources

Genetic Variant of SARS-CoV-2 Isolates in Indonesia: Spike Glycoprotein Gene [PDF]

Journal of Pure and Applied Microbiology, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus and the primary causative agent of coronavirus disease 2019 (COVID-19), first occurred in China and rapidly spread worldwide.
Arif Nur Muhammad Ansori, Viol Dhea Kharisma, Sahal Sabilil Muttaqin, Yulanda Antonius, Arli Aditya Parikesit   +4 more
doaj   +2 more sources

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming [PDF]

Molecules, 2020
Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2′) cleavage sites that are processed by human host proteases.
Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin, Maurizio Pellecchia   +5 more
doaj   +3 more sources

Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence [PDF]

Journal of NeuroVirology, 2001
The spike (S) glycoprotein of mouse hepatitis virus (MHV) is a major determinant of neurovirulence. Using targeted recombination we previously demonstrated that the S gene of the highly neurovirulent MHV-4 conferred a dramatic increase in neurovirulence ...
Chua, MingMing, Seo, Su-hun, Phillips, Joanna J, Weiss, Susan R   +3 more
core   +5 more sources

Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike.

PLoS Pathogens, 2016
Lassa virus is an enveloped, bi-segmented RNA virus and the most prevalent and fatal of all Old World arenaviruses. Virus entry into the host cell is mediated by a tripartite surface spike complex, which is composed of two viral glycoprotein subunits ...
Sai Li, Zhaoyang Sun, Rhys Pryce, Marie-Laure Parsy, Sarah K Fehling, Katrin Schlie, C Alistair Siebert, Wolfgang Garten, Thomas A Bowden, Thomas Strecker, Juha T Huiskonen   +10 more
doaj   +2 more sources

Controlling the SARS-CoV-2 Spike Glycoprotein Conformation [PDF]

Nature Structural & Molecular Biology, 2020
Abstract The coronavirus (CoV) viral host cell fusion spike (S) protein is the primary immunogenic target for virus neutralization and the current focus of many vaccine design efforts. The highly flexible S-protein, with its mobile domains, presents a moving target to the immune system.
Rory Henderson, Robert J Edwards, Katayoun Mansouri, Katarzyna Janowska, Victoria Stalls, Sophie Gobeil, Megan Kopp, Allen Hsu, Mario Borgnia, Rob Parks, Barton F. Haynes, Priyamvada Acharya   +11 more
openaire   +4 more sources

Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein. [PDF]

Nat Commun, 2023
Abstract SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 receptor, and an open state that does so but displays more exposed antigenic surface.
Calvaresi V, Wrobel AG, Toporowska J, Hammerschmid D, Doores KJ, Bradshaw RT, Parsons RB, Benton DJ, Roustan C, Reading E, Malim MH, Gamblin SJ, Politis A.   +12 more
europepmc   +7 more sources