Results 41 to 50 of about 73,847 (203)

Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. [PDF]

PLoS Pathogens, 2018
The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 (ACE2) and mediates fusion of the viral and cellular membranes through a pre- to ...
Wenfei Song, Miao Gui, Xinquan Wang, Ye Xiang   +3 more
doaj   +1 more source

In Silico Studies on The Potential of Green Tea Catechin Compounds (Camellia sinensis) as Antiviral of SARS CoV-2 Againts Spike Glycoprotein (6LZG) and Main Protease (5R7Y)

Journal of Food and Pharmaceutical Sciences, 2022
COVID-19 is a disease caused by SARS CoV-2 by producing structural proteins and non-structural proteins. SARS CoV-2 uses a spike glycoprotein to bind ACE-2 receptors in host cells and uses main protease to replicate.
Futna Naufa, Roihatul Mutiah, Yen Yen Ari Indrawijaya   +2 more
doaj   +1 more source

Can polyoxometalates (POMs) prevent of coronavirus 2019-nCoV cell entry? Interaction of POMs with TMPRSS2 and spike receptor domain complexed with ACE2 (ACE2-RBD): Virtual screening approaches

Informatics in Medicine Unlocked, 2022
The unexpected appearance and global spread of COVID-19 create significant difficulties for healthcare systems and present an unusual challenge for the fast discovery of medicines to combat this fatal disease.
Nahid Shahabadi, Mohammad Mahdavi, Saba Zendehcheshm   +2 more
doaj   +1 more source

Evolution of SARS-CoV-2 spike glycoprotein [PDF]

, 2020
Abstract The spike glycoprotein (S) of SARS-CoV-2 mediates attachment of the virus to cell surface receptors and fusion between virus and cell membranes1. The receptor for SARS-CoV-2, like that for SARS-CoV, is the human cell-surface membrane protein ACE22–4.
Antoni Wrobel, Donald Benton, Pengqi Xu, Chloë Roustan, Stephen Martin, Peter Rosenthal, John Skehel, Steven Gamblin   +7 more
openaire   +1 more source

High‐resolution analysis of individual spike peptide‐specific CD4+ T‐cell responses in vaccine recipients and COVID‐19 patients

Clinical & Translational Immunology, 2022
Objectives Potential differences in the breadth, distribution and magnitude of CD4+ T‐cell responses directed against the SARS‐CoV‐2 spike glycoprotein between vaccinees, COVID‐19 patients and subjects who experienced both ways of immunisation have not ...
Hendrik Karsten, Leon Cords, Tim Westphal, Maximilian Knapp, Thomas Theo Brehm, Lennart Hermanussen, Till Frederik Omansen, Stefan Schmiedel, Robin Woost, Vanessa Ditt, Sven Peine, Marc Lütgehetmann, Samuel Huber, Christin Ackermann, Melanie Wittner, Marylyn Martina Addo, Alessandro Sette, John Sidney, Julian Schulze zur Wiesch   +18 more
doaj   +1 more source

Photo‐Triggered, Fast, and Fluorogenic Thiophene‐Based Cycloalkynes for the Bioorthogonal Fluorescent Labeling of 1,3‐Dipole‐Tagged Molecules in No‐Wash Conditions

Angewandte Chemie, EarlyView.
Thiophene is king! The fusion of thiophene rings to cycloalkynes super‐charged their copper‐free click chemistry applications, by (1) enhancing the alkyne reactivity (fastest cyclooctyne to date) and (2) rendering the alkyne fluorogenic (with fluorescence enhancement up to 150‐fold upon reaction), making these bioorthogonal reagents ideal for tracking ...
Jurgen Schulz, Zoeisha S. Chinoy, Tarek Khalaf, Yukang Li, Pengchen Ma, Dennis Svatunek, Kendall N. Houk, Frédéric Friscourt   +7 more
wiley   +2 more sources

CD4+ T Cells of Prostate Cancer Patients Have Decreased Immune Responses to Antigens Derived From SARS-CoV-2 Spike Glycoprotein

Frontiers in Immunology, 2021
The adaptive immune response to severe acute respiratory coronavirus 2 (SARS-CoV-2) is important for vaccine development and in the recovery from coronavirus disease 2019 (COVID-19).
Pavla Taborska, Zuzana Strizova, Dmitry Stakheev, Ludek Sojka, Ludek Sojka, Jirina Bartunkova, Daniel Smrz   +6 more
doaj   +1 more source

Murine Coronavirus Spike Glycoprotein [PDF]

, 2001
The mature Coronavirus spike is a large, oligomeric, type I integral membrane glycoprotein that projects about 20 nm from the surface of infected cells and virions. In this extracellular position, the spikes function to bind the cellular receptors extending from opposing membranes.
openaire   +2 more sources

Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein

Nature Communications, 2020
Here, the authors characterise the binding and neutralisation properties of CR3022, a neutralising Ab isolated from a convalescent SARS patient, against SARS-CoV-2 spike trimers and show using Cryo-EM the disruption of SARS-CoV-2 spike by CR3022 Fab.
Antoni G. Wrobel, Donald J. Benton, Saira Hussain, Ruth Harvey, Stephen R. Martin, Chloë Roustan, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin   +8 more
doaj   +1 more source

Production of Lentivirus particles pseudotyped with SARS-CoV-2 spike protein for neutralisation or drug antiviral activity assays

One Health & Risk Management, 2023
Introduction. Lentivirus particles are commonly employed as gene delivery vectors due to their ability to transduce both dividing and non-dividing cells efficiently.
Mariana ULINICI
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