Results 41 to 50 of about 76,288 (243)

Hunting for the SARS-CoV-2 Spike Glycoprotein Ancestor [PDF]

, 2020
Abstract Objective: In December 2019 a novel coronavirus (SARS-CoV-2) that is causing the current COVID-19 pandemic was identified in Wuhan, China. Many questions have been raised about its origin and adaptation to humans. In the present work we performed a genetic analysis of the Spike glycoprotein (S) of SARS-CoV-2 and other related ...
Alejandro Flores-Alanis, Luisa Sandner-Miranda, Gabriela Delgado, Alejandro Cravioto, Rosario Morales-Espinosa   +4 more
openaire   +1 more source

Inhibitory potentials of ivermectin, nafamostat, and camostat on spike protein and some nonstructural proteins of SARS-CoV-2: Virtual screening approach

Jurnal Teknologi Laboratorium, 2022
The search for potent oral drugs either through synthetic routes or by drug repurposing for combating the dreaded covid-19 virus is still ongoing. The coronavirus spike glycoprotein and several other non-structural proteins play crucial roles in the ...
Haruna Isiyaku Umar, Ijeoma Akunna Duru, Uchechi Emmanuela Enenebeaku, Lynda Chioma Ngozi Olehi, Christian Ebere Enyoh, Chidi Edbert Duru   +5 more
doaj   +1 more source

Detergent modulates the conformational equilibrium of SARS-CoV-2 Spike during cryo-EM structural determination

Nature Communications, 2023
The Spike glycoprotein of SARS-CoV-2 mediates viral entry into the host cell via the interaction between its receptor binding domain (RBD) and human angiotensin-converting enzyme 2 (ACE2). Spike RBD has been reported to adopt two primary conformations, a
Shawn B. Egri, Xue Wang, Marco A. Díaz-Salinas, Jeremy Luban, Natalya V. Dudkina, James B. Munro, Kuang Shen   +6 more
doaj   +1 more source

Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH-and Cysteine Protease-Independent Fc gamma R Pathway [PDF]

, 2011
Copyright © 2011, American Society for Microbiology. All Rights Reserved.Public health measures successfully contained outbreaks of the severe acute respiratory syndrome coronavirus (SARS-CoV) infection.
Cheung, Chung y, Marc Daëron, Li, PH, Altmeyer, Ralf, Ping H. Li, Leung, Hiu L, Escriou, N, Dutry, Isabelle, Ming S. Yip, Kien, Francois, Cheung, CY, Dutry, I, Li, Ping H, Benoît Callendret, Nal, B, Chung Y. Cheung, Altmeyer, R, Peiris, J S Malik, Ralf Altmeyer, Bruzzone, R, Jaume, Martial, Martial Jaume, Nicolas Escriou, Callendret, B, Isabelle Dutry, Escriou, Nicolas, Beatrice Nal, Kien, F, Francois Kien, Jaume, M, Yip, MS, Bruzzone, Roberto, J. S. Malik Peiris, Yip, Ming S, Daëron, Marc, Roberto Bruzzone, Hiu L. Leung, Leung, HL, Peiris, JSM, Nal, Beatrice, Daeron, M   +40 more
core   +1 more source

Characterization of spike glycoprotein of 2019-nCoV on virus entry and its immune cross-reactivity with spike glycoprotein of SARS-CoV [PDF]

, 2020
Abstract Since beginning of this century, there have already been three zoonotic outbreaks caused by beta coronaviruses (CoV), SARS-CoV in 2002-2003, MERS-CoV in 2012, and the newly identified 2019-nCoV in late 2019, Wuhan, China. As to Feb 10th, 2020, there are over 40,000 confirmed cases and over 900 deaths. However, little is known about the
Jin, Qi, Wang, Jianwei, Qian, Zhaohui, Ou, Xiuyuan, Liu, Yan, Lei, Xiaobo, Li, Pei, Mi, Dan, Ren, Lili, Guo, Li, Chen, Ting, Hu, Jiaxing, Xiang, Zichun, Mu, Zhixia, Chen, Xing, Chen, Jieyong, Hu, Keping   +16 more
openaire   +1 more source

N-ferrocenylmethyl-Derivatives As Spike Glycoprotein Inhibitors Of SARS-CoV-2 Using In Silico Approaches

, 2020
Background and Objectives: By the end of 2019, a novel human coronavirus outbreak started in Wuhan and spread to the world becoming a global pandemic, patients were diagnosed with severe respiratory syndrome.
Touhami, Lanez, NADJIBA, ZEGHEB, LANEZ, Elhafnaoui   +2 more
core   +1 more source

An optimised method for the production of MERS-CoV spike expressing viral pseudotypes [PDF]

, 2015
The production and use of pseudotyped viral particles is widely established for many viruses, and applications in the fields of serology and vaccine development are manifold.
Ferrara, Francesca, K. Grehan, Temperton, Nigel J., F. Ferrara, Grehan, Keith, N. Temperton   +5 more
core   +1 more source

Molecular Docking study of Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein with Saikosaponin, a Triterpenoid Natural Product

, 2020
The appearance of SARS-CoV-2 has resulted ~19000 deaths and ~423000 infections worldwide as of March 24, 2020. Coronavirus spike (S) glycoproteins hooks on target cells and binds to the angiotensin-converting enzyme 2 (ACE2) receptor.
Bhaskar, Bagchi, Tamal Goswami (8623293), Tamal, Goswami, Bhaskar Bagchi (8624775)   +3 more
core   +1 more source

Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein. [PDF]

, 2020
At the end of 2019, a new highly virulent coronavirus known under the name SARS-CoV-2 emerged as a human pathogen. One key feature of SARS-CoV-2 is the presence of an enigmatic insertion in the spike glycoprotein gene representing a novel multibasic S1 ...
Kalbermatter, David, Harder, Daniel, Plattet, Philippe, Lemmin, Thomas, Fotiadis, Dimitrios   +4 more
core   +1 more source

Evolution of SARS-CoV-2 spike glycoprotein [PDF]

, 2020
Abstract The spike glycoprotein (S) of SARS-CoV-2 mediates attachment of the virus to cell surface receptors and fusion between virus and cell membranes1. The receptor for SARS-CoV-2, like that for SARS-CoV, is the human cell-surface membrane protein ACE22–4.
Antoni Wrobel, Donald Benton, Pengqi Xu, Chloë Roustan, Stephen Martin, Peter Rosenthal, John Skehel, Steven Gamblin   +7 more
openaire   +1 more source