Results 61 to 70 of about 97,509 (188)

Can polyoxometalates (POMs) prevent of coronavirus 2019-nCoV cell entry? Interaction of POMs with TMPRSS2 and spike receptor domain complexed with ACE2 (ACE2-RBD): Virtual screening approaches

Informatics in Medicine Unlocked, 2022
The unexpected appearance and global spread of COVID-19 create significant difficulties for healthcare systems and present an unusual challenge for the fast discovery of medicines to combat this fatal disease.
Nahid Shahabadi, Mohammad Mahdavi, Saba Zendehcheshm   +2 more
doaj   +1 more source

Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus [PDF]

Virologica Sinica, 2010
A group of SARS-like coronaviruses (SL-CoV) have been identified in horseshoe bats. Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental
Hou, Yu-xuan, Peng, Cheng, Han, Zheng-gang, Zhou, Peng, Chen, Ji-guo, Shi, Zheng-li   +5 more
openaire   +2 more sources

CD4+ T Cells of Prostate Cancer Patients Have Decreased Immune Responses to Antigens Derived From SARS-CoV-2 Spike Glycoprotein

Frontiers in Immunology, 2021
The adaptive immune response to severe acute respiratory coronavirus 2 (SARS-CoV-2) is important for vaccine development and in the recovery from coronavirus disease 2019 (COVID-19).
Pavla Taborska, Zuzana Strizova, Dmitry Stakheev, Ludek Sojka, Ludek Sojka, Jirina Bartunkova, Daniel Smrz   +6 more
doaj   +1 more source

Tomato spotted wilt virus glycoproteins induce the formation of endoplasmic reticulum- and Golgi-derived pleomorphic membrane structures in plant cells [PDF]

, 2008
Tomato spotted wilt virus (TSWV) particles are spherical and enveloped, an uncommon feature among plant infecting viruses. Previous studies have shown that virus particle formation involves the enwrapment of ribonucleoproteins with viral glycoprotein ...
Denecke, J., Foresti, O., Goldbach, R.W., Kormelink, R.J.M., Ribeiro, D.M.O.G., Wellink, J.   +5 more
core   +2 more sources

An optimised method for the production of MERS-CoV spike expressing viral pseudotypes [PDF]

, 2015
The production and use of pseudotyped viral particles is widely established for many viruses, and applications in the fields of serology and vaccine development are manifold.
Carnell, Ferrara, Kutner, Mather, Molesti, Qian, Scott, Temperton, Wang, Zhao, Zufferey, Zufferey   +11 more
core   +2 more sources

Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence [PDF]

Journal of NeuroVirology, 2001
The spike (S) glycoprotein of mouse hepatitis virus (MHV) is a major determinant of neurovirulence. Using targeted recombination we previously demonstrated that the S gene of the highly neurovirulent MHV-4 conferred a dramatic increase in neurovirulence to the mildly neurovirulent MHV-A59.
Phillips, Joanna J, Chua, MingMing, Seo, Su-hun, Weiss, Susan R   +3 more
openaire   +4 more sources

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. [PDF]

, 2020
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
Cheng, Genhong, Ding, Xiao, Huang, Baoying, Jiang, Taijiao, Meng, Jing, Niu, Peihua, Peng, Yousong, Quan, Lijun, Sheng, Jie, Tan, Wenjie, Wang, Jiangyuan, Wang, Xianyue, Wu, Aiping, Xia, Zanxian, Zhang, Zheng, Zhu, Zhaozhong   +15 more
core  

Production of Lentivirus particles pseudotyped with SARS-CoV-2 spike protein for neutralisation or drug antiviral activity assays

One Health & Risk Management, 2023
Introduction. Lentivirus particles are commonly employed as gene delivery vectors due to their ability to transduce both dividing and non-dividing cells efficiently.
Mariana ULINICI
doaj  

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +8 more sources

Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. [PDF]

, 2020
On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization (WHO).
Du, Lanying, Jiang, Shibo, Ojcius, David M, Pan, Chungen, Yu, Fei   +4 more
core   +1 more source