Results 61 to 70 of about 76,288 (243)

Virtual Screening of Curcumin and Its Analogs Against the Spike Surface Glycoprotein of SARS-CoV-2 and SARS-CoV

, 2020
COVID-19, a new pandemic caused by SARS-CoV-2, was first identified in 2019 in Wuhan, China. The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74 % identity and use similar mechanisms to gain entry into the cell.
Suresh B, Pakala, Ashish, Shah, Harnisha, Patel, Malathi, Rajendran, Ashish, Patel, Prashanthi, Karyala   +5 more
core   +1 more source

Murine Coronavirus Spike Glycoprotein [PDF]

, 2001
The mature Coronavirus spike is a large, oligomeric, type I integral membrane glycoprotein that projects about 20 nm from the surface of infected cells and virions. In this extracellular position, the spikes function to bind the cellular receptors extending from opposing membranes.
openaire   +2 more sources

Screening Antibodies Raised Against the Spike Glycoprotein of SARS-CoV-2 to Support the Development of Rapid Antigen Assays

, 2020
The spike glycoprotein of SARS-CoV-2 is a highly conserved surface protein and as such may represent a good target for immunoassay detection. We screened a variety of antibodies that were reactive to the S glycoprotein in a highly sensitive liquid ...
Gleda, Hermansky, Yuri, Hwang, Lucas, Kraft, Puneet K, Dewan, Caitlin E, Anderson, Gonzalo, Domingo, Luis F, Alonzo, Bernhard H, Weigl, Veronika, Glukhova, Kevin P, Nichols, David, Cate, Bryan, Barnhart, Samantha, Kuhn, Jason, Cantera, Brianda, Barrios-Lopez, Zeba, Islam, Valentine, de Puyraimond, David, Boyle, Lorraine, Lillis, Ethan, Spencer, Eileen, Murphy, Benjamin, Grant, Roger, Peck, Karine, Herve, Allison, Golden   +24 more
core   +1 more source

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer [PDF]

Nature, 2016
The tremendous pandemic potential of coronaviruses was demonstrated twice in the past few decades by two global outbreaks of deadly pneumonia. Entry of coronaviruses into cells is mediated by the transmembrane spike glycoprotein S, which forms a trimer carrying receptor-binding and membrane fusion functions.
Walls, Alexandra, Tortorici, M. Alejandra, Bosch, Berend-Jan, Frenz, Brandon, Rottier, Peter J. M., Dimaio, Frank, Rey, Félix A., Veesler, David   +7 more
openaire   +5 more sources

Screening of World Approved Drugs against Highly Dynamical Spike Glycoprotein SARS-CoV-2 using CaverDock and Machine Learning

, 2020
The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes pathological pulmonary symptoms. Most efforts to develop vaccines and drugs against this virus target the spike glycoprotein, particularly its S1 subunit, which is recognised by ...
Jiri, Filipovic, Ondrej, Vavra, Jiri, Damborsky, Gaspar, Pinto, Sérgio M., Marques, David, Bednar   +5 more
core   +1 more source

Human monoclonal antibody combination against SARS coronavirus : synergy and coverage of escape mutants [PDF]

, 2006
Background: Experimental animal data show that protection against severe acute respiratory syndrome coronavirus (SARS-CoV) infection with human monoclonal antibodies (mAbs) is feasible.
Peiris, Joseph S. M., Cox Freek, Doerr, Hans Wilhelm, Brink, Edward van den, van den Brink Edward N, Hans Wilhelm Doerr, ter Meulen Jan, Doerr Hans Wilhelm, Cheung, Chung Y., de Kruif John, van Deventer, Els, Jaap Goudsmit, Leo L. M., Poon, Leo L M Poon, Marissen Wilfred E, Marissen, Wilfred E., Poon Leo L. M, van den Brink, Edward N., Chow Vincent T, Chung Y Cheung, Wolfgang Preiser, Leung, Cynthia S.W., Preiser, Wolfgang, Van Deventer, E, Bogaards Johannes A, Freek Cox, Wilfred E Marissen, Els van Deventer, Joseph S M Peiris, Chow, Tak-Kwong Vincent, Bakker, Arjen Q., Leung, CSW, Chow, Vincent T., de Kruif, John, Goudsmit Jaap, ter Meulen, Jan, Deventer, Els van, Kruif, John de, De Kruif, J, John de Kruif, Cynthia S W Leung, Jan ter Meulen, Bogaards, Johannes A., Cox, F, Preiser Wolfgang, Cox, Freek, Goudsmit, J, Peiris Joseph S. M, Poon, LLM, Cheung, CY, Johannes A Bogaards, Doerr, HW, van Deventer Els, Marissen, WE, Bakker Arjen Q, Peiris, Joseph S.M., Poon, Leo L. M., Leung Cynthia S. W, Chow, VT, Edward N van den Brink, Bogaards, JA, Vincent T Chow, Arjen Q Bakker, Poon, Leo L.M., Cheung Chung Y, Van Den Brink, EN, Peiris, Joseph Sriyal Malik, Ter Meulen, J, Leung, Cynthia S. W., Goudsmit, Jaap, Peiris, JSM, Meulen, Jan ter, Bakker, AQ, Preiser, W   +73 more
core   +1 more source

Identification of the Fusion Peptide-Containing Region in Betacoronavirus Spike Glycoproteins [PDF]

Journal of Virology, 2016
ABSTRACT The fusion peptides (FP) play an essential role in fusion of viral envelope with cellular membranes. The location and properties of the FPs in the spike (S) glycoproteins of different coronaviruses (CoV) have not yet been determined. Through amino acid sequence analysis of S proteins of representative CoVs, we identified
Xiuyuan, Ou, Wangliang, Zheng, Yiwei, Shan, Zhixia, Mu, Samuel R, Dominguez, Kathryn V, Holmes, Zhaohui, Qian   +6 more
openaire   +2 more sources

Production of Lentivirus particles pseudotyped with SARS-CoV-2 spike protein for neutralisation or drug antiviral activity assays

One Health & Risk Management, 2023
Introduction. Lentivirus particles are commonly employed as gene delivery vectors due to their ability to transduce both dividing and non-dividing cells efficiently.
Mariana ULINICI
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Glycoprotein molecular dynamics analysis: SARS-CoV-2 spike glycoprotein case study

, 2022
Molecular Dynamics (MD) is a method used to calculate the movement of atoms and molecules broadly applied to several aspects of science. It involves computational simulation, which makes it, at first glance, not easily accessible. The rise of several automated tools to perform molecular simulations has allowed researchers to navigate through the ...
Coutinho, João Victor Paccini, Macedo-da-Silva, Janaina, Mule, Simon Ngao, Kronenberger, Thales, Rosa-Fernandes, Livia, Wrenger, Carsten, Palmisano, Giuseppe   +6 more
openaire   +2 more sources