Results 81 to 90 of about 97,509 (188)

Neutralization assay with SARS-CoV-1 and SARS-CoV-2 spike pseudotyped murine leukemia virions

Virology Journal, 2021
Background Virus neutralization by antibodies is an important prognostic factor in many viral diseases. To easily and rapidly measure titers of neutralizing antibodies in serum or plasma, we developed pseudovirion particles composed of the spike ...
Yue Zheng, Erin T. Larragoite, Elizabeth S. C. P. Williams, Juan Lama, Isabel Cisneros, Julio C. Delgado, Patricia Slev, Jenna Rychert, Emily A. Innis, Mayte Coiras, Matthew T. Rondina, Adam M. Spivak, Vicente Planelles   +12 more
doaj   +1 more source

Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage [PDF]

, 2012
© 2012 Millet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Chen, A Roumier, AG Wise, B Fievet, B Nal, B Treanor, B Treanor, BJ Bosch, BT Fievet, Béatrice Nal, C Drosten, CE McBride, CE McBride, Chung-Yan Cheung, CM Finnerty, CM Petit, CM Petit, CY Cheung, D Cavanagh, E Formstecher, E Lontok, François Kien, G Simmons, G Simmons, H Ma, Hiu-Lan Leung, HS Kim, Huiying Li, I Nefkens, IC Huang, J Haedicke, Jean Kaoru Millet, JK Locker, Joseph S. Malik Peiris, JP Nuesch, JP Richard, JS Peiris, K Hamada, K Hamada, KT Teoh, L Naldini, M Algrain, M Barrero-Villar, M Baumgartner, M Fromont-Racine, M Jaume, Martial Jaume, MH Naghavi, MJ Moore, MW Howard, N Gupta, P Wang, PC Woo, PC Woo, R Lasserre, R Zufferey, Ralf Marius Altmeyer, RG Fehon, RI Connor, Roberto Bruzzone, S Charrin, S Yonemura, SF Altschul, SK Lau, Stefan Pöhlmann, T Crepaldi, T Giroglou, T Kuiken, T Mori, TG Ksiazek, V Das, W Li, Wing-Lim Chan, WJ Smith, Y Kubo, YJ Zhang, YL Siu, Yu-Lam Siu, YW Kam, YW Kam   +79 more
core   +6 more sources

Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike.

PLoS Pathogens, 2016
Lassa virus is an enveloped, bi-segmented RNA virus and the most prevalent and fatal of all Old World arenaviruses. Virus entry into the host cell is mediated by a tripartite surface spike complex, which is composed of two viral glycoprotein subunits ...
Sai Li, Zhaoyang Sun, Rhys Pryce, Marie-Laure Parsy, Sarah K Fehling, Katrin Schlie, C Alistair Siebert, Wolfgang Garten, Thomas A Bowden, Thomas Strecker, Juha T Huiskonen   +10 more
doaj   +1 more source

Repositioning of Ligands That Target the Spike Glycoprotein as Potential Drugs for SARS-CoV-2 in an In Silico Study

Molecules, 2020
The worldwide health emergency of the SARS-CoV-2 pandemic and the absence of a specific treatment for this new coronavirus have led to the use of computational strategies (drug repositioning) to search for treatments.
Gema Lizbeth Ramírez-Salinas, Marlet Martínez-Archundia, José Correa-Basurto, Jazmín García-Machorro   +3 more
doaj   +1 more source

A linear B-cell epitope close to the furin cleavage site within the S1 domain of SARS-CoV-2 Spike protein discriminates the humoral immune response of nucleic acid- and protein-based vaccine cohorts

Frontiers in Immunology, 2023
BackgroundUnderstanding the humoral immune response towards viral infection and vaccination is instrumental in developing therapeutic tools to fight and restrict the viral spread of global pandemics. Of particular interest are the specificity and breadth
Peter Lorenz, Felix Steinbeck, Franz Mai, Emil C. Reisinger, Brigitte Müller-Hilke, Brigitte Müller-Hilke   +5 more
doaj   +1 more source

The alphaviruses: gene expression, replication, and evolution [PDF]

, 1994
The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for these viruses.
Strauss, Ellen G., Strauss, James H.
core   +1 more source

Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]

, 2020
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P., Lagana, B., Pioli, C., Rosado, M. M., Sesti, G.   +4 more
core   +2 more sources

High-Potency Polypeptide-based Interference for Coronavirus Spike Glycoproteins [PDF]

, 2021
Abstract The world is experiencing an unprecedented coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 spike protein-based vaccines are currently the main preventive agent to fight against the virus.
Qinghua Wang, Jianpeng Ma, Adam Acevedo
openaire   +1 more source

SARS-CoV-2 spike treatment and transfection impairs airway epithelial repair

ERJ Open Research
Background The airway epithelium serves as a physical and immune barrier against inhaled insults. This tissue is susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and, following injury, the airway epithelium undergoes ...
Tony Guo, Gurpreet Singhera, Jasmine Memar Vaghri, Wan Yi Liang, Janice M. Leung, Del Dorscheid   +5 more
doaj   +1 more source

Molecular Targets for Diagnostics and Therapeutics of Severe Acute Respiratory Syndrome (SARS-CoV)

Journal of Pharmacy & Pharmaceutical Sciences, 2008
PURPOSE. The large number of deaths in a short period of time due to the spread of severe acute respiratory syndrome (SARS) infection led to the unparalleled collaborative efforts world wide to determine and characterize the new coronavirus (SARS-CoV ...
Mavanur R. Suresh, Pravin K. Bhatnagar, Dipankar Das   +2 more
doaj   +1 more source