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The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes pathological pulmonary symptoms. Most efforts to develop vaccines and drugs against this virus target the spike glycoprotein, particularly its S1 subunit, which is recognised by ...
Gaspar P. Pinto +5 more
doaj +1 more source
Electrochemical immunosensors are often described as innovative strategies to tackle urgent epidemiological needs, such as the detection of SARS-CoV-2 main biomarker, the spike glycoprotein. Nevertheless, there is a great variety of receptors, especially
Douglas Vieira Thomaz +4 more
doaj +1 more source
Potassium is a trigger for conformational change in the fusion spike of an enveloped RNA virus [PDF]
Many enveloped viruses enter cells through the endocytic network, from which they must subsequently escape through fusion of viral and endosomal membranes.
Barr, JN +7 more
core +1 more source
Immunization with vesicular stomatitis virus (VSV)-vectored COVID-19 vaccine candidates expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly on expression of the ACE2 receptor at the muscular injection site. Here, we
Adriano Taddeo +9 more
doaj +1 more source
SARS CoV subunit vaccine: Antibodymediated neutralisation and enhancement [PDF]
1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2.
Altmeyer, R +14 more
core +1 more source
Over-expression of an S-domain receptor-like kinase extracellular domain improves panicle architecture and grain yield in rice. [PDF]
The S-domain receptor kinase (SRK) comprises a highly polymorphic subfamily of receptor-like kinases (RLKs) originally found to be involved in the self-incompatibility response in Brassica.
Li, Hongyu +8 more
core +2 more sources
Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E [PDF]
Post-translational modifications and correct subcellular localization of viral structural proteins are prerequisites for assembly and budding of enveloped viruses. Coronaviruses, like the severe acute respiratory syndrome-associated virus (SARS-CoV), bud
Altmeyer, R +12 more
core +3 more sources
Phylogenetic distribution and predominant genotype of the avian infectious bronchitis virus in China during 2008-2009 [PDF]
Background The nephropathogenic avian infectious bronchitis (IB) caused unprecedented economic losses to the commercial chicken industry of China in 2008-2009. To investigate the prevalence of nephropathogenic IB in China, eighty IBV isolates
Jun Ji +10 more
core +1 more source
Molecular dynamics simulations and enhanced sampling methods reveal the role of glycans and the energetics of glycan-mediated conformational switches in the receptor binding domains of the SARS-CoV-2 trimeric spike glycoprotein.
Yui Tik Pang +4 more
doaj +1 more source
Differences in virus receptor for type I and type II feline infectious peritonitis virus. [PDF]
Feline infectious peritonitis viruses (FIPVs) are classified into type I and type II serogroups. Here, we report that feline aminopeptidase N (APN), a cell-surface metalloprotease on the intestinal, lung and kidney epithelial cells, is a receptor for ...
Hohdatsu, T +4 more
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