Results 71 to 80 of about 97,509 (188)

Genetic Variant of SARS-CoV-2 Isolates in Indonesia: Spike Glycoprotein Gene

Journal of Pure and Applied Microbiology, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus and the primary causative agent of coronavirus disease 2019 (COVID-19), first occurred in China and rapidly spread worldwide.
Arif Nur Muhammad Ansori, Viol Dhea Kharisma, Sahal Sabilil Muttaqin, Yulanda Antonius, Arli Aditya Parikesit   +4 more
doaj   +1 more source

Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer Simulations

Frontiers in Immunology, 2021
SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1 domain of the spike glycoprotein of SARS-CoV-2 binds to human angiotensin-converting enzyme 2 (hACE2) via its receptor-binding domain, while the S2 domain facilitates fusion
Damiano Buratto, Abhishek Saxena, Qun Ji, Guang Yang, Sergio Pantano, Sergio Pantano, Francesco Zonta   +6 more
doaj   +1 more source

Sindbis virus ts103 has a mutation in glycoprotein E2 that leads to defective assembly of virions [PDF]

, 1989
Sindbis virus mutant ts103 is aberrant in the assembly of virus particles. During virus budding, proper nucleocapsid-glycoprotein interactions fail to occur such that particles containing many nucleocapsids are formed, and the final yield of virus is low.
Hahn, Chang S., Lenches, Edith M., Rice, Charles M., Strauss, Ellen G., Strauss, James H.   +4 more
core  

Mass spectrometry in the molecular differentiation between SARS-CoV-2 Spike glycoprotein and mRNA anti COVID-19 vaccine Spike glycoprotein.

, 2023
SARS-CoV-2 spike proteins, also known as S proteins, are the proteins on the surface of the virus that allow it to bind to and enter host cells. The spike protein binds to the ACE2 receptor on human cells, which allows the virus to enter and infect the host. The spike protein is also the target of many COVID-19 vaccines, as it is a unique and essential
Cristoni, Simone, Mantovani, Mauro
openaire   +1 more source

Designing of multi-Epitope vaccine against spike glycoprotein of SARS-CoV-2 using immunoinformatics approach

Medicine in Omics
Background: COVID-19 caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome) has created an alarming situation worldwide. The surface (S) glycoprotein of novel coronavirus, encoded by the genome of SARS-CoV-2, plays an role in attachment, fusion as well
Deepak Kumar Jha, Niti Yashvardhini, Amit Kumar, Manjush Gaurav, Kumar Sayrav   +4 more
doaj   +1 more source

Characterization of spike glycoprotein of 2019-nCoV on virus entry and its immune cross-reactivity with spike glycoprotein of SARS-CoV [PDF]

, 2020
Abstract Since beginning of this century, there have already been three zoonotic outbreaks caused by beta coronaviruses (CoV), SARS-CoV in 2002-2003, MERS-CoV in 2012, and the newly identified 2019-nCoV in late 2019, Wuhan, China. As to Feb 10th, 2020, there are over 40,000 confirmed cases and over 900 deaths. However, little is known about the
Jin, Qi, Wang, Jianwei, Qian, Zhaohui, Ou, Xiuyuan, Liu, Yan, Lei, Xiaobo, Li, Pei, Mi, Dan, Ren, Lili, Guo, Li, Chen, Ting, Hu, Jiaxing, Xiang, Zichun, Mu, Zhixia, Chen, Xing, Chen, Jieyong, Hu, Keping   +16 more
openaire   +1 more source

Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate

Frontiers in Plant Science, 2022
Given the complex maturation requirements of viral glycoproteins and the challenge they often pose for expression in plants, the identification of host constraints precluding their efficient production is a priority for the molecular farming of vaccines.
Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Matthew Verbeek, Warren de Moor, Warren de Moor, Ros Chapman, Ros Chapman, Ann Meyers, Georgia Schäfer, Georgia Schäfer, Georgia Schäfer, Anna-Lise Williamson, Anna-Lise Williamson, Anna-Lise Williamson, Edward Rybicki, Edward Rybicki   +17 more
doaj   +1 more source

A review of coronavirus infection in the central nervous system of cats and mice. [PDF]

, 2001
Feline infectious peritonitis (FIP) is a common cause of death in cats. Management of this disease has been hampered by difficulties identifying the infection and determining the immunological status of affected cats and by high variability in the ...
Foley, JE, Leutenegger, C
core  

The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]

, 1992
Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F, Buchmeier, MJ, Fazakerley, JK, Parker, SE   +3 more
core   +1 more source

FRETing over SARS-CoV-2: Conformational Dynamics of the Spike Glycoprotein [PDF]

Cell Host & Microbe, 2020
In this issue of Cell Host & Microbe, Lu et al. utilize single-molecule FRET to reveal the conformation dynamics of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, showing transitions from a closed ground state to the open receptor-accessible conformation via an on-path intermediate.
Serrão, Vitor Hugo B., Lee, Jeffrey E.
openaire   +2 more sources