Results 71 to 80 of about 76,288 (243)

Repurposing of FDA-Approved Toremifene to Treat COVID-19 by Blocking the Spike Glycoprotein and NSP14 of SARS-CoV-2

, 2020
The global pandemic of Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to the death of more than 350,000 worldwide and over 100,000 in the United States alone.
William R., Martin, Feixiong, Cheng
core   +1 more source

Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer Simulations

Frontiers in Immunology, 2021
SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1 domain of the spike glycoprotein of SARS-CoV-2 binds to human angiotensin-converting enzyme 2 (hACE2) via its receptor-binding domain, while the S2 domain facilitates fusion
Damiano Buratto, Abhishek Saxena, Qun Ji, Guang Yang, Sergio Pantano, Sergio Pantano, Francesco Zonta   +6 more
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Designing of multi-Epitope vaccine against spike glycoprotein of SARS-CoV-2 using immunoinformatics approach

Medicine in Omics
Background: COVID-19 caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome) has created an alarming situation worldwide. The surface (S) glycoprotein of novel coronavirus, encoded by the genome of SARS-CoV-2, plays an role in attachment, fusion as well
Deepak Kumar Jha, Niti Yashvardhini, Amit Kumar, Manjush Gaurav, Kumar Sayrav   +4 more
doaj   +1 more source

Cell-Free Glycoengineering of the Recombinant SARS-CoV-2 Spike Glycoprotein

Frontiers in Bioengineering and Biotechnology, 2021
The baculovirus-insect cell expression system is readily utilized to produce viral glycoproteins for research as well as for subunit vaccines and vaccine candidates, for instance against SARS-CoV-2 infections.
Johannes Ruhnau, Valerian Grote, Mariana Juarez-Osorio, Dunja Bruder, Dunja Bruder, Reza Mahour, Erdmann Rapp, Erdmann Rapp, Thomas F. T. Rexer, Udo Reichl, Udo Reichl   +10 more
doaj   +1 more source

Interface‐Engineered Binary Framework Composites: Advancing Porous Materials for Precision Medicine

Advanced Materials Interfaces, EarlyView.
Binary framework composites integrate two complementary porous architectures into a unified platform, enabling multifunctional design, enhanced structural tunability, and improved physicochemical performance. By combining high surface area, ordered porosity, interfacial synergy, and versatile functionalization, these hybrid materials offer new ...
Navid Rabiee, Mohammad Rabiee, Mohammad Akrami‐Hasan‐Kohal, Sidi A. Bencherif   +3 more
wiley   +1 more source

Role of glycoprotein PE2 in formation and maturation of the Sindbis virus spike [PDF]

Journal of Virology, 1997
Sindbis virus envelope assembly is a multistep process resulting in the maturation of a rigid, highly ordered T=4 icosahedral protein lattice containing 80 spikes composed of trimers of E1-E2 heterodimers. Intramolecular disulfide bonds within E1 stabilize E1-E1 associations required for envelope formation and maintenance of the envelope's structural ...
M, Carleton, H, Lee, M, Mulvey, D T, Brown   +3 more
openaire   +2 more sources

Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate

Frontiers in Plant Science, 2022
Given the complex maturation requirements of viral glycoproteins and the challenge they often pose for expression in plants, the identification of host constraints precluding their efficient production is a priority for the molecular farming of vaccines.
Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Matthew Verbeek, Warren de Moor, Warren de Moor, Ros Chapman, Ros Chapman, Ann Meyers, Georgia Schäfer, Georgia Schäfer, Georgia Schäfer, Anna-Lise Williamson, Anna-Lise Williamson, Anna-Lise Williamson, Edward Rybicki, Edward Rybicki   +17 more
doaj   +1 more source

The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms [PDF]

, 2022
: Heparin, a naturally occurring glycosaminoglycan, has been found to have antiviral activity against SARS-CoV-2, the causative virus of COVID-19. To elucidate the mechanistic basis for the antiviral activity of heparin, we investigated the binding of ...
Paiardi, Giulia, Richter, Stefan, Wade, Rebecca C, Urbinati, Chiara, Rusnati, Marco, Oreste, Pasqua   +5 more
core   +1 more source

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source