Results 51 to 60 of about 76,288 (243)
Frontiers in Microbiology, 2022 Porcine hemagglutinating encephalomyelitis virus (PHEV) is a Betacoronavirus characterized by neurological symptoms and a worldwide prevalence. Although PHEV is one of the earliest discovered porcine coronaviruses, it remains poorly studied.
Amina Nawal Bahoussi +10 more
doaj +1 more source
Uncovering cryptic pockets in the SARS-CoV-2 spike glycoprotein [PDF]
Structure, 2021 ABSTRACT The recent global COVID-19 pandemic has prompted a rapid response in terms of vaccine and drug development targeting the viral pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this work, we modelled a complete membrane-embedded SARS-CoV-2 spike (S) protein, the primary target of vaccine and ...
Lorena Zuzic +13 more
openaire +6 more sources
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. [PDF]
PLoS Pathogens, 2018 The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 (ACE2) and mediates fusion of the viral and cellular membranes through a pre- to ...
Wenfei Song +3 more
doaj +1 more source
Journal of Food and Pharmaceutical Sciences, 2022 COVID-19 is a disease caused by SARS CoV-2 by producing structural proteins and non-structural proteins. SARS CoV-2 uses a spike glycoprotein to bind ACE-2 receptors in host cells and uses main protease to replicate.
Futna Naufa +2 more
doaj +1 more source
Clinical & Translational Immunology, 2022 Objectives Potential differences in the breadth, distribution and magnitude of CD4+ T‐cell responses directed against the SARS‐CoV‐2 spike glycoprotein between vaccinees, COVID‐19 patients and subjects who experienced both ways of immunisation have not ...
Hendrik Karsten +18 more
doaj +1 more source
Informatics in Medicine Unlocked, 2022 The unexpected appearance and global spread of COVID-19 create significant difficulties for healthcare systems and present an unusual challenge for the fast discovery of medicines to combat this fatal disease.
Nahid Shahabadi +2 more
doaj +1 more source
, 2020 In this study we used molecular docking method to test 248 drugs related to the virus research against spike glycoprotein of SARS-CoV-2. For ten top-ranked drugs the binding sites and interactions with spike glycoprotein were analyzed in detail. The best-
Kateryna, Miroshnychenko +1 more
core +1 more source
Computer Simulations of the interaction between SARS-CoV-2 spike glycoprotein and different surfaces [PDF]
, 2020 A prominent feature of coronaviruses is the presence of a large glycoprotein spike protruding from a lipidic membrane. This glycoprotein spike determines the interaction of coronaviruses with the environment and the host.
Malaspina, David C. +3 more
core +1 more source
Therapeutic targeting of coronavirus spike glycoprotein priming [PDF]
, 2020 Abstract Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2’) cleavage sites that are processed by human host proteases.
Maurizio Pellecchia +5 more
openaire +1 more source
Frontiers in Immunology, 2021 The adaptive immune response to severe acute respiratory coronavirus 2 (SARS-CoV-2) is important for vaccine development and in the recovery from coronavirus disease 2019 (COVID-19).
Pavla Taborska +6 more
doaj +1 more source