Results 51 to 60 of about 73,847 (203)

Evolutionary aspect of spike glycoprotein's conformational dynamics

Physical Chemistry Chemical Physics
The conformational transition of the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein from the “closed” to “open” state.
Wentao Xu, Tianyu Guo, Haibin Su
openaire   +2 more sources

Therapeutic targeting of coronavirus spike glycoprotein priming [PDF]

, 2020
Abstract Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2’) cleavage sites that are processed by human host proteases.
Maurizio Pellecchia, Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin   +5 more
openaire   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Genetic Variant of SARS-CoV-2 Isolates in Indonesia: Spike Glycoprotein Gene

Journal of Pure and Applied Microbiology, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus and the primary causative agent of coronavirus disease 2019 (COVID-19), first occurred in China and rapidly spread worldwide.
Arif Nur Muhammad Ansori, Viol Dhea Kharisma, Sahal Sabilil Muttaqin, Yulanda Antonius, Arli Aditya Parikesit   +4 more
doaj   +1 more source

Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer Simulations

Frontiers in Immunology, 2021
SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1 domain of the spike glycoprotein of SARS-CoV-2 binds to human angiotensin-converting enzyme 2 (hACE2) via its receptor-binding domain, while the S2 domain facilitates fusion
Damiano Buratto, Abhishek Saxena, Qun Ji, Guang Yang, Sergio Pantano, Sergio Pantano, Francesco Zonta   +6 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Designing of multi-Epitope vaccine against spike glycoprotein of SARS-CoV-2 using immunoinformatics approach

Medicine in Omics
Background: COVID-19 caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome) has created an alarming situation worldwide. The surface (S) glycoprotein of novel coronavirus, encoded by the genome of SARS-CoV-2, plays an role in attachment, fusion as well
Deepak Kumar Jha, Niti Yashvardhini, Amit Kumar, Manjush Gaurav, Kumar Sayrav   +4 more
doaj   +1 more source

Cell-Free Glycoengineering of the Recombinant SARS-CoV-2 Spike Glycoprotein

Frontiers in Bioengineering and Biotechnology, 2021
The baculovirus-insect cell expression system is readily utilized to produce viral glycoproteins for research as well as for subunit vaccines and vaccine candidates, for instance against SARS-CoV-2 infections.
Johannes Ruhnau, Valerian Grote, Mariana Juarez-Osorio, Dunja Bruder, Dunja Bruder, Reza Mahour, Erdmann Rapp, Erdmann Rapp, Thomas F. T. Rexer, Udo Reichl, Udo Reichl   +10 more
doaj   +1 more source

Bio‐Inspired Biopolymeric Implantable Platform for Localized and Sustained Drug Delivery in Solid Tumor Treatment

Advanced Functional Materials, EarlyView.
A bio‐inspired biopolymeric implantable drug delivery platform enables localized and sustained release of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38) in solid tumor treatment. The three‐dimensional (3D) structured crosslinked‐chitosan implants are fabricated via 3D‐printed molds and provide drug release over 3 months, significantly inhibiting tumor growth ...
Mercedes Lozano‐Garcia, Constantine Vogiatzis, Alejandra Planells‐Devesa, Emre Dikici, Caroline Vieira Maluf, Vasudev Vivekanand Nayak, Paulo G. Coelho, Lukasz Witek, Alicia Bilbao, Daniel Bilbao, Prasoon Mohan, Sapna Deo, Sylvia Daunert   +12 more
wiley   +1 more source

Investigating Constraints Along the Plant Secretory Pathway to Improve Production of a SARS-CoV-2 Spike Vaccine Candidate

Frontiers in Plant Science, 2022
Given the complex maturation requirements of viral glycoproteins and the challenge they often pose for expression in plants, the identification of host constraints precluding their efficient production is a priority for the molecular farming of vaccines.
Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Emmanuel Margolin, Matthew Verbeek, Warren de Moor, Warren de Moor, Ros Chapman, Ros Chapman, Ann Meyers, Georgia Schäfer, Georgia Schäfer, Georgia Schäfer, Anna-Lise Williamson, Anna-Lise Williamson, Anna-Lise Williamson, Edward Rybicki, Edward Rybicki   +17 more
doaj   +1 more source