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Mutations and Evolution of the SARS-CoV-2 Spike Protein

Viruses, 2022
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis
Nicholas Magazine, Tianyi Zhang, Yingying Wu, Michael C. McGee, Gianluca Veggiani, Weishan Huang   +5 more
doaj   +2 more sources

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Science, 2020
Hitting SARS-CoV-2 in a new spot A key target for therapeutic antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the spike protein, a trimeric protein complex with each monomer comprising an S1 and an S2 domain that ...
Xiangyang Chi, R. Yan, Jun Zhang, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang, Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning Li, Xiaohong Song, Yi Chen, L. Xia, L. Fu, L. Hou, Junjie Xu, Changming Yu, Jianmin Li, Qiang Zhou, Wei Chen   +23 more
semanticscholar   +3 more sources

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Molecular Cell, 2020
The pandemic coronavirus SARS-CoV-2 threatens public health worldwide. The viral spike protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2 cleavage site containing multiple arginine residues (multibasic) not found in closely related ...
M. Hoffmann, Hannah Kleine-Weber, S. Pöhlmann   +2 more
semanticscholar   +3 more sources

Mutations in human SARS-CoV-2 spike proteins, potential drug binding and epitope sites for COVID-19 therapeutics development

Current Research in Structural Biology, 2022
The comparison of 303,250 human SARS-CoV-2 spike protein sequences with the reference protein sequence Wuhan-Hu-1, showed ∼96.5% of the spike protein sequence has undergone the mutations till date, since outbreak of the COVID-19 pandemic disease that was
Kunchur Guruprasad
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The ORF8 Protein of SARS-CoV-2 Modulates the Spike Protein and Its Implications in Viral Transmission

Frontiers in Microbiology, 2022
COVID-19 is currently global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Accompanying the rapid spread of the error-prone RNA-based genome, several dominant SARS-CoV-2 variants have been genetically identified.
Jen-Mei Chou, Jen-Mei Chou, Jo-Ling Tsai, Jo-Ling Tsai, Jo-Ning Hung, Jo-Ning Hung, I-Hua Chen, I-Hua Chen, I-Hua Chen, Szu-Ting Chen, Szu-Ting Chen, Ming-Han Tsai, Ming-Han Tsai, Ming-Han Tsai   +13 more
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A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein Mutations

COVID, 2023
The emergence of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has sparked intense research on its spike protein, which is essential for viral entrance into host cells.
Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha, Rene B. Khan, Hezekiel M. Kumalo   +4 more
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Different In Silico Approaches Using Heterocyclic Derivatives against the Binding between Different Lineages of SARS-CoV-2 and ACE2

Molecules, 2023
Over the last few years, the study of the SARS-CoV-2 spike protein and its mutations has become essential in understanding how it interacts with human host receptors.
Federica Sipala, Gianfranco Cavallaro, Giuseppe Forte, Cristina Satriano, Alessandro Giuffrida, Aurore Fraix, Angelo Spadaro, Salvatore Petralia, Carmela Bonaccorso, Cosimo Gianluca Fortuna, Simone Ronsisvalle   +10 more
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SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

Science, 2022
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo–electron microscopy (cryo-EM) structural analysis of the Omicron variant spike
D. Mannar, J. Saville, Xing Zhu, S. S. Srivastava, A. Berezuk, Katharine S. Tuttle, A. Márquez, Inna Sekirov, S. Subramaniam   +8 more
semanticscholar   +1 more source

FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

Journal of Lipid Research, 2022
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues.
Katrina Mekhail, Minhyoung Lee, Michael Sugiyama, Audrey Astori, Jonathan St-Germain, Elyse Latreille, Negar Khosraviani, Kuiru Wei, Zhijie Li, James Rini, Warren L. Lee, Costin Antonescu, Brian Raught, Gregory D. Fairn   +13 more
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Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

Science China Life Sciences, 2020
Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai 200031, China; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant ...
Xintian Xu, Ping Chen, Jingfang Wang, Jiannan Feng, Hui Zhou, Xuan Li, Wu Zhong, Pei Hao   +7 more
semanticscholar   +1 more source