Results 1 to 10 of about 3,974,865 (310)

Spike protein of SARS-CoV-2 Omicron variant: An in-silico study evaluating spike interactions and immune evasion

Frontiers in Public Health, 2022
BackgroundThe fundamentals of the infectivity and immune evasion of the SARS-CoV-2 Omicron variant are not yet fully understood. Here, we carried out an in-silico study analyzing the spike protein, the protein electrostatic potential, and the potential ...
Jose A. Jimenez Ruiz, Cecilia Lopez Ramirez, Cecilia Lopez Ramirez, Jose Luis Lopez-Campos, Jose Luis Lopez-Campos   +4 more
doaj   +2 more sources

SARS-CoV-2 Spike protein alters microglial purinergic signaling

Frontiers in Immunology, 2023
Despite long-term sequelae of COVID-19 are emerging as a substantial public health concern, the mechanism underlying these processes still unclear. Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of ...
Vinícius Santos Alves, Stephanie Alexia Cristina Silva Santos, Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Renata Rodrigues dos Reis, Mariana L. Calazans, Gabriel Gripp Fernandes, Leticia Silva Antônio, Emanuelle V. de Lima, Eleonora Kurtenbach, Jerson Lima Silva, Fabricia Lima Fontes-Dantas, Fabricia Lima Fontes-Dantas, Giselle Fazzioni Passos, Cláudia Pinto Figueiredo, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +16 more
doaj   +1 more source

Structural insights on the differentiation and reversion of conformational changes in SARS-CoV-2 spike protein models across variants occurring from December, 2019 to November, 2021

ImmunoInformatics
Conformational changes in the SARS-CoV-2 spike protein are critical for understanding viral evolution. In this study, we provide comparative structural and electrostatic analyses across variants, revealing both differentiation and reversion patterns not ...
Marni E. Cueno, Kenichi Imai
doaj   +1 more source

Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein

Frontiers in Immunology, 2021
The outbreak and worldwide pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a significant impact on global economy and human health. In order to reduce the disease spread, 16 monoclonal antibodies (McAbs) again SARS-
Ge Li, Ge Li, Aiping Wang, Yumei Chen, Yaning Sun, Yongkun Du, Xun Wang, Peiyang Ding, Rui Jia, Yanwei Wang, Gaiping Zhang, Gaiping Zhang   +11 more
doaj   +1 more source

Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage

eLife
The trimeric SARS-CoV-2 Spike protein mediates viral attachment facilitating cell entry. Most COVID-19 vaccines direct mammalian cells to express the Spike protein or deliver it directly via inoculation to engender a protective immune response.
Chung Park, Il-Young Hwang, Serena Li-Sue Yan, Sinmanus Vimonpatranon, Danlan Wei, Don Van Ryk, Alexandre Girard, Claudia Cicala, James Arthos, John H Kehrl   +9 more
doaj   +1 more source

Metalloprotease-Dependent S2′-Activation Promotes Cell–Cell Fusion and Syncytiation of SARS-CoV-2

Viruses, 2022
SARS-CoV-2 cell–cell fusion and syncytiation is an emerging pathomechanism in COVID-19, but the precise factors contributing to the process remain ill-defined.
James V. Harte, Samantha L. Wakerlin, Andrew J. Lindsay, Justin V. McCarthy, Caroline Coleman-Vaughan   +4 more
doaj   +1 more source

Phytochemicals as a potential inhibitor of Spike Protein of SARS-CoV-2 Omicron Variant

Jurnal Kedokteran Diponegoro, 2023
Background: More than 50 mutations have been found in Omicron SARS-CoV-2. Most Omicron mutations are located in the spike protein, which plays a pivotal role in virus infection.
Tuti Ratnasari, Faizah Fulyani, Endang Mahati   +2 more
doaj   +1 more source

Cdc42 improve SARS-CoV-2 spike protein-induced cellular senescence through activating of Wnt/β-Catenin signaling pathway

Frontiers in Cellular and Infection Microbiology
IntroductionSARS-CoV-2 infection drove senescent cells and the senescence-associated phenotypes were reported playing roles in disease progression, which contributes to severe COVID-19 and related sequelae. Cdc42 is involved in the regulation of cellular
Chunmei Nong, Chunmei Nong, Chunmei Nong, Zhenzhen Wu, Chan Yang, Wei Xu, Linyi Luo, Jianping Zhou, Lihan Shen, Yinghua Chen, Yinghua Chen, Yaoqin Yuan, Guodong Hu, Guodong Hu, Guodong Hu   +14 more
doaj   +1 more source

Sialic Acid Binding Properties of Soluble Coronavirus Spike (S1) Proteins: Differences between Infectious Bronchitis Virus and Transmissible Gastroenteritis Virus

Viruses, 2013
The spike proteins of a number of coronaviruses are able to bind to sialic acids present on the cell surface. The importance of this sialic acid binding ability during infection is, however, quite different. We compared the spike protein of transmissible
Christine Winter, Georg Herrler, Ann-Kathrin Mork, Martina Hesse, Katarina Shahwan   +4 more
doaj   +1 more source

Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Nature Communications
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein is a hallmark of SARS-CoV-2 and plays a crucial role in viral infection. However, the mechanism underlying furin activation and its regulation remain poorly understood.
Shengjun Wang, Wei Ran, Lingyu Sun, Qingchi Fan, Yuanqi Zhao, Bowen Wang, Jinghong Yang, Yuqi He, Ying Wu, Yuanyuan Wang, Luoyi Chen, Arpaporn Chuchuay, Yuyu You, Xinhai Zhu, Xiaojuan Wang, Ye Chen, Yanqun Wang, Yao-Qing Chen, Yanqiu Yuan, Jincun Zhao, Yang Mao   +20 more
doaj   +1 more source