Results 1 to 10 of about 131,065 (253)

In silico Identification of Characteristics Spike Glycoprotein of SARS-CoV-2 in the Development Novel Candidates for COVID-19 Infectious Diseases

Journal of Biomedicine and Translational Research, 2020
Background: The emergence of infectious diseases caused by SARS-CoV-2 has resulted in more than 90,000 infections and 3,000 deaths. The coronavirus spike glycoprotein encourages the entry of SARS-CoV-2 into cells and is the main target of antivirals ...
Taufik Muhammad Fakih, Mentari Luthfika Dewi   +1 more
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The Comparison of SARS-CoV-2, SARS-CoV, and MERS-CoV Genome and Spike Protein Variations

Jurnal Riset Biologi dan Aplikasinya, 2021
SARS-CoV-2 is a virus that has caused COVID-19 pandemic. This virus is a new variant of the SARS-CoV virus and also closely related to MERS-CoV, which caused similar acute respiratory infections. All these viruses recognize target cells by binding to the
Choirun Nita Fikriani, I Kade Karisma Gita Ardana, Dwi Listyorini   +2 more
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SARS-CoV-2 delta (B.1.617.2) spike protein adjuvanted with Alum-3M-052 enhances antibody production and neutralization ability

Frontiers in Public Health, 2023
BackgroundOptimizing adjuvant is one of the critical methods to improve the vaccine. 3M-052, a novel TLR7/8 agonist which was designed for slow dissemination at the injection site, has a potential as adjuvant, but its performance as a vaccine adjuvant ...
Hong Huang, Zhongcheng Zhou, Xinxin Xiong, Zhihai Liu, Xiaoxue Zheng, Qingli Quan, Meixing Yu   +6 more
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Production of SARS-CoV-2 N Protein-Specific Monoclonal Antibody and Its Application in an ELISA-Based Detection System and Targeting the Interaction Between the Spike C-Terminal Domain and N Protein

Frontiers in Microbiology, 2021
SARS-CoV-2 infections continue to spread quickly by human-to-human transmission around the world. Therefore, developing methods to rapidly detect SARS-CoV-2 with high sensitivity are still urgently needed.
Dongbum Kim, Jinsoo Kim, Sangkyu Park, Minyoung Kim, Kyeongbin Baek, Mijeong Kang, Jun-Kyu Choi, Sony Maharjan, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwon, Hyung-Joo Kwon   +11 more
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Dynamics of binding ability prediction between spike protein and human ACE2 reveals the adaptive strategy of SARS-CoV-2 in humans

Scientific Reports, 2021
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel coronavirus causing the COVID-19 pandemic in 2020. High adaptive plasticity on the spike protein of SASR-CoV-2 enables it to transmit across different host species.
Xia Xue, Jianxiang Shi, Hongen Xu, Yaping Qin, Zengguang Yang, Shuaisheng Feng, Danhua Liu, Liguo Jian, Linlin Hua, Yaohe Wang, Qi Zhang, Xueyong Huang, Xiaoju Zhang, Xinxin Li, Chunguang Chen, Jiancheng Guo, Wenxue Tang, Jianbo Liu   +17 more
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A cell-based, SARS-CoV-2 spike protein interaction assay to inform the neutralising capacity of recombinant and patient sera antibodies

Frontiers in Virology, 2023
IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine ...
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J. Hill, Aekkachai Tuekprakhon, Zhi Li, Cristina Matas de las Heras, Ana Teodosio, Andrea S. Lavado, Robert Moring, Ayesha Ashraf, Timothy R. Dafforn, Dimitris K. Grammatopoulos, Dimitris K. Grammatopoulos, John Gordon, Catherine A. Brady, Lawrence S. Young, Nicholas M. Barnes, Nicholas M. Barnes, Zania Stamataki, Omar S. Qureshi   +24 more
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Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection.

PLoS ONE, 2021
BackgroundThe effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood.ObjectivesWe sought to determine the effects of prior exposure to HCoV Betacoronavirus HKU1 spike ...
Stacey A Lapp, Venkata Viswanadh Edara, Austin Lu, Lilin Lai, Laila Hussaini, Ann Chahroudi, Larry J Anderson, Mehul S Suthar, Evan J Anderson, Christina A Rostad   +9 more
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Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein

Frontiers in Immunology, 2021
The outbreak and worldwide pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a significant impact on global economy and human health. In order to reduce the disease spread, 16 monoclonal antibodies (McAbs) again SARS-
Ge Li, Ge Li, Aiping Wang, Yumei Chen, Yaning Sun, Yongkun Du, Xun Wang, Peiyang Ding, Rui Jia, Yanwei Wang, Gaiping Zhang, Gaiping Zhang   +11 more
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Recombinant ACE2 protein protects against acute lung injury induced by SARS-CoV-2 spike RBD protein

Critical Care, 2022
Background SARS-CoV-2 infection leads to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Both clinical data and animal experiments suggest that the renin–angiotensin system (RAS) is involved in the pathogenesis of SARS-CoV-2 ...
Lingbing Zhang, Yandan Zhang, Xia Qin, Xuejun Jiang, Jun Zhang, Lejiao Mao, Ziqi Jiang, Yu Jiang, Gang Liu, Jingfu Qiu, Chengzhi Chen, Feng Qiu, Zhen Zou   +12 more
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Immunogenicity of a vaccinia virus-based severe acute respiratory syndrome coronavirus 2 vaccine candidate

Frontiers in Immunology, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines provide essential tools for the control of the COVID-19 pandemic. A number of technologies have been employed to develop SARS-CoV-2 vaccines, including the inactivated SARS-CoV-2 ...
Shan Mei, Zhangling Fan, Xiaoman Liu, Fei Zhao, Yu Huang, Liang Wei, Yamei Hu, Yu Xie, Liming Wang, Bin Ai, Chen Liang, Fengwen Xu, Fei Guo   +12 more
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