Results 31 to 40 of about 90,748 (118)

Prion-like Domains in Spike Protein of SARS-CoV-2 Differ across Its Variants and Enable Changes in Affinity to ACE2

Microorganisms, 2022
Currently, the world is struggling with the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
George Tetz, Victor Tetz
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SARS-CoV-2 spike protein displays sequence similarities with paramyxovirus surface proteins; a bioinformatics study.

PLoS ONE, 2021
Recent emergence of SARS-CoV-2 and associated COVID-19 pandemic have posed a great challenge for the scientific community. In this study, we performed bioinformatic analyses on SARS-CoV-2 protein sequences, trying to unravel potential molecular ...
Ehsan Ahmadi, Mohammad Reza Zabihi, Ramin Hosseinzadeh, Leila Mohamed Khosroshahi, Farshid Noorbakhsh   +4 more
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FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

Journal of Lipid Research, 2022
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues.
Katrina Mekhail, Minhyoung Lee, Michael Sugiyama, Audrey Astori, Jonathan St-Germain, Elyse Latreille, Negar Khosraviani, Kuiru Wei, Zhijie Li, James Rini, Warren L. Lee, Costin Antonescu, Brian Raught, Gregory D. Fairn   +13 more
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Emergence of SARS‐CoV‐2 spike protein at the vaccination site

Immunity, Inflammation and Disease, 2023
Background The anti‐coronavirus disease 2019 (COVID‐19) vaccines are of paramount importance in the fight against the COVID‐19 pandemic. Both viral vector‐ and nucleic acid‐based vaccines are known to effectively induce protection against the severe ...
Annika Beck, Hanna Dietenberger, Sebastian N. Kunz, Kevin Mellert, Peter Möller   +4 more
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SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathway

MedComm, 2021
SARS‐CoV‐2 is an enveloped positive‐sense RNA virus that depends on host factors for all stages of its life. Membrane receptor ACE2 is a well‐established factor for SARS‐CoV‐2 docking.
Lin Zhao, Kunhong Zhong, Jia Zhao, Xin Yong, Aiping Tong, Da Jia   +5 more
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Site Density Functional Theory and Structural Bioinformatics Analysis of the SARS-CoV Spike Protein and hACE2 Complex

Molecules, 2022
The entry of the SARS-CoV-2, a causative agent of COVID-19, into human host cells is mediated by the SARS-CoV-2 spike (S) glycoprotein, which critically depends on the formation of complexes involving the spike protein receptor-binding domain (RBD) and ...
Nitesh Kumawat, Andrejs Tucs, Soumen Bera, Gennady N. Chuev, Marat Valiev, Marina V. Fedotova, Sergey E. Kruchinin, Koji Tsuda, Adnan Sljoka, Amit Chakraborty   +9 more
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Design, Construction and Expression of Spike Highly Conserved Region (HCR) SARS-CoV-2 and Cholera Toxin Subunit B Fusion Protein in Lactococcus lactis NZ3900

Journal of Tropical Life Science
Prevention of SARS-CoV-2 transmission has primarily been achieved through vaccination, which is generally administered via injection and may cause discomfort.
Suryanata Kesuma, Oktavia Rahayu Adianingsih, Sri Winarsih, Nashi Widodo, Valentina Yurina   +4 more
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SARS-CoV-2 spike fusion peptide trans interaction with phosphatidylserine lipid triggers membrane fusion for viral entry

mBio
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike is the fusion machine for host cell entry. Still, the mechanism by which spike protein interacts with the target lipid membrane to facilitate membrane fusion during entry is not fully ...
Puspangana Singh, Purba Pahari, Srija Mukherjee, Sharmistha Karmakar, Markus Hoffmann, Taraknath Mandal, Dibyendu Kumar Das   +6 more
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A new DNA aptamer which binds to SARS-CoV-2 spike protein and reduces pro-inflammatory response

Scientific Reports
COVID-19 caused by SARS-CoV-2 spread rapidly around the world, endangering the health of people globally. The SARS-CoV-2 spike protein initiates entry into target cells by binding to human angiotensin-converting enzyme 2 (ACE2).
Woong Kim, Eun Su Song, Song Ha Lee, Seung Ho Yang, Junhyung Cho, Seok-Jun Kim   +5 more
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Determinants of susceptibility to SARS-CoV-2 infection in murine ACE2

Journal of Virology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes angiotensin-converting enzyme 2 (ACE2) as a receptor to enter host cells, and primary receptor recognition of the spike protein is a major determinant of the host range of SARS-CoV-2 ...
Takashi Kondo, Rigel Suzuki, Hisano Yajima, Sachiho Kawahara, Kodai Yamaya, Takaya Ichikawa, Shuhei Tsujino, Saori Suzuki, Tomokazu Tamura, Takao Hashiguchi, Takasuke Fukuhara   +10 more
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