Results 51 to 60 of about 131,065 (253)

A method for the generation of pseudovirus particles bearing SARS coronavirus spike protein in high yields

Cell Structure and Function, 2022
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has threatened human health and the global economy. Development of additional vaccines and therapeutics is urgently required, but such development with live virus must be ...
Yoichiro Fujioka, Sayaka Kashiwagi, Aiko Yoshida, Aya O. Satoh, Mari Fujioka, Maho Amano, Yohei Yamauchi, Yusuke Ohba   +7 more
doaj   +1 more source

Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. [PDF]

, 2020
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses.
Cheng, Genhong, Ding, Xiao, Huang, Baoying, Jiang, Taijiao, Meng, Jing, Niu, Peihua, Peng, Yousong, Quan, Lijun, Sheng, Jie, Tan, Wenjie, Wang, Jiangyuan, Wang, Xianyue, Wu, Aiping, Xia, Zanxian, Zhang, Zheng, Zhu, Zhaozhong   +15 more
core  

Molecular aspects of MERS-CoV [PDF]

, 2017
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Ahmed, Shamsah H., Al-Tawfiq, Jaffar A., Bazzi, Ali M., Rabaan, Ali A.   +3 more
core   +1 more source

Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus

Heliyon, 2023
The human infectious disease COVID-19 caused by the SARS-CoV-2 virus has become a major threat to global public health. Developing a vaccine is the preferred prophylactic response to epidemics and pandemics.
Nancy E. Hernandez, Wojciech Jankowski, Rahel Frick, Simon P. Kelow, Joseph H. Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D. Khare, Roland L. Dunbrack, Jr., Jeffrey J. Gray, Zuben E. Sauna   +10 more
doaj   +1 more source

Methods for estimating the case fatality ratio for a novel, emerging infectious disease. [PDF]

, 2005
During the course of an epidemic of a potentially fatal disease, it is important that the case fatality ratio be well estimated. The authors propose a novel method for doing so based on the Kaplan-Meier survival procedure, jointly considering two ...
Anderson, RM, Chan, WS, Cox, DR, Donnelly, CA, Fraser, C, Ghani, AC, Griffin, JT, Hedley, AJ, Ho, LM, Lam, TH, Leung, GM   +10 more
core   +1 more source

Substitution at Aspartic Acid 1128 in the SARS Coronavirus Spike Glycoprotein Mediates Escape from a S2 Domain-Targeting Neutralizing Monoclonal Antibody [PDF]

, 2014
The Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) is the etiological agent for the infectious disease, SARS, which first emerged 10 years ago. SARS-CoV is a zoonotic virus that has crossed the species barriers to infect humans.
Keng, CT, Leung, SW, Ng, OW, Peiris, JSM, Poon, LLM, Tan, YJ   +5 more
core   +1 more source

Evaluation of spike protein antigens for SARS-CoV-2 serology

Journal of Virological Methods, 2021
AbstractBackgroundSpike protein domains are being used in various serology-based assays to detect prior exposure to SARS-CoV-2 virus. However, there has been limited comparison of human antibody titers against various spike protein antigens among COVID-19 infected patients.MethodsWe compared four spike proteins (RBD, S1, S2 and a stabilized spike ...
Suraj Jagtap, Ratnasri K, Priyanka Valloly, Rakhi Sharma, Satyaghosh Maurya, Anushree Gaigore, Chitra Ardhya, Dayananda S. Biligi, Bapu Koundinya Desiraju, Uma Chandra Mouli Natchu, Deepak Kumar Saini, Rahul Roy   +11 more
openaire   +3 more sources

Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. [PDF]

, 2020
On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization (WHO).
Du, Lanying, Jiang, Shibo, Ojcius, David M, Pan, Chungen, Yu, Fei   +4 more
core   +1 more source

Stability and expression of SARS-CoV-2 spike-protein mutations

Molecular and Cellular Biochemistry, 2022
AbstractProtein fold stability likely plays a role in SARS-CoV-2 S-protein evolution, together with ACE2 binding and antibody evasion. While few thermodynamic stability data are available for S-protein mutants, many systematic experimental data exist for their expression.
Kristoffer T. Bæk, Rukmankesh Mehra, Kasper P. Kepp   +2 more
openaire   +2 more sources

SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2) as a binding receptor to enter cells via clathrin-mediated endocytosis (CME).
Jinliang Wang, Guan Yang, Xinxin Wang, Zhiyuan Wen, Lei Shuai, Jie Luo, Chong Wang, Ziruo Sun, Renqiang Liu, Jinying Ge, Xijun He, Ronghong Hua, Xijun Wang, Xiao Yang, Weiye Chen, Gongxun Zhong, Zhigao Bu   +16 more
doaj   +1 more source