Results 51 to 60 of about 99,522,423 (293)
SARS-CoV-2 spike protein similarity with pathogenic human paramyxoviruses.
, 2021 The result of similarity searches between SARS-CoV-2 spike protein versus different human paramyxoviruses. The X axis shows maximum score for each protein query and the Y axis shows negative log E value for each protein query.
Ehsan Ahmadi (2804020) +4 more
core +1 more source
The binding mechanism of ivermectin and levosalbutamol with spike protein of SARS-CoV-2 [PDF]
Structural Chemistry, 2021 Abstract In this study, we have investigated the binding mechanism of two FDA approved drugs (ivermectin and levosalbutamol) with the spike protein of SARs-CoV-2 using three different computational modeling techniques. Molecular docking results predict that ivermectin shows a large binding affinity for spike protein (-9.0 kcal/mol) compared to ...
Joyanta Kumar Saha, Md. Jahir Raihan
openaire +2 more sources
, 2023 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, has given rise to many new variants with increased transmissibility and the ability to evade vaccine protection.
Amy S. Lee +6 more
core +1 more source
The local topological free energy of the SARS-CoV-2 Spike protein [PDF]
Polymers, 2021 The novel coronavirus SARS-CoV-2 infects human cells using a mechanism that involves binding and structural rearrangement of its spike protein. Understanding protein rearrangement and identifying specific residues where mutations affect protein rearrangement has attracted a lot of attention for drug development.
Quenisha Baldwin +2 more
openaire +2 more sources
Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2
Molecules, 2022 The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged as a pandemic and has inflicted enormous damage on the lives of the people and economy of many countries worldwide. However, therapeutic agents against SARS-CoV-2 remain unclear.
Takashi Tanikawa +9 more
openaire +3 more sources
A Glycan Gate Controls Opening of the SARS-CoV-2 Spike Protein [PDF]
Nature Chemistry, 2021 Abstract SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded “down” to an exposed “up” state in order to bind the human ACE2 receptor and infect cells.
Terra Sztain +16 more
openaire +6 more sources
A. Risk factors associated with the absence of seroconversion Spike-Protein-RBD IgG anti-SARS-CoV-2.
, 2021 B. Risk factors associated with a low Spike-Protein-RBD IgG anti-SARS-CoV-2 (IgG 7000AU/mL, Last quartile vs other three quartiles).
Jean-Philippe Bourdenx (11524599) +6 more
core +1 more source
Characterization of a SARS-CoV-2 spike protein reference material
Analytical and Bioanalytical Chemistry, 2022 Abstract Development of diagnostic testing capability has advanced with unprecedented pace in response to the COVID-19 pandemic. An undesirable effect of such speed is a lack of standardization, often leading to unreliable test results. To assist the research community surmount this challenge, the National Research Council Canada has prepared a SARS ...
Stocks, Bradley B. +3 more
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Cell Structure and Function, 2022 The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has threatened human health and the global economy. Development of additional vaccines and therapeutics is urgently required, but such development with live virus must be ...
Yoichiro Fujioka +7 more
doaj +1 more source
The SARS-CoV-2 spike protein is vulnerable to moderate electric fields [PDF]
Nature Communications, 2021 AbstractMost of the ongoing projects aimed at the development of specific therapies and vaccines against COVID-19 use the SARS-CoV-2 spike (S) protein as the main target. The binding of the spike protein with the ACE2 receptor (ACE2) of the host cell constitutes the first and key step for virus entry.
Claudia R. Arbeitman +3 more
openaire +6 more sources