Results 61 to 70 of about 99,522,423 (293)

Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus

Heliyon, 2023
The human infectious disease COVID-19 caused by the SARS-CoV-2 virus has become a major threat to global public health. Developing a vaccine is the preferred prophylactic response to epidemics and pandemics.
Nancy E. Hernandez, Wojciech Jankowski, Rahel Frick, Simon P. Kelow, Joseph H. Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D. Khare, Roland L. Dunbrack, Jr., Jeffrey J. Gray, Zuben E. Sauna   +10 more
doaj   +1 more source

Computational epitope map of SARS-CoV-2 spike protein

PLOS Computational Biology, 2021
The primary immunological target of COVID-19 vaccines is the SARS-CoV-2 spike (S) protein. S is exposed on the viral surface and mediates viral entry into the host cell. To identify possible antibody binding sites, we performed multi-microsecond molecular dynamics simulations of a 4.1 million atom system containing a patch of viral membrane with four ...
Sikora, Mateusz, von Bülow, Sören, Blanc, Florian, Gecht, Michael, Covino, Roberto, Hummer, Gerhard   +5 more
openaire   +10 more sources

Deglycosylation of SARS-CoV-1 spike restores binding to LRRC15.

, 2023
Comparison of SARS-CoV-1 spike to SARS-CoV-2 spike, where enzymatic removal of most N-linked glycans by PNGase F results in the SARS-CoV-1 spike gaining the ability to bind LRRC15 at similar levels to SARS-CoV-2 spike.
Edward J. D. Greenwood (14564377), Brian M. Ortmann (14564383), Gavin J. Wright (7443272), Samuel James Watson (14564380), Christian M. Gawden-Bone (14564386), Jarrod Shilts (8322756), Pehuén Pereyra Gerber (12072880), Paul J. Lehner (156536), James A. Nathan (9302264), Markus Hoffmann (223014), Stefan Pöhlmann (142445), Nicholas J. Matheson (10109719), Tekle Pauzaite (14564389), Ana Teixeira-Silva (418174), Thomas W. M. Crozier (14564374), Ildar Gabaev (193128)   +15 more
core   +1 more source

SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2) as a binding receptor to enter cells via clathrin-mediated endocytosis (CME).
Jinliang Wang, Guan Yang, Xinxin Wang, Zhiyuan Wen, Lei Shuai, Jie Luo, Chong Wang, Ziruo Sun, Renqiang Liu, Jinying Ge, Xijun He, Ronghong Hua, Xijun Wang, Xiao Yang, Weiye Chen, Gongxun Zhong, Zhigao Bu   +16 more
doaj   +1 more source

Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein

, 2023
Novel coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and continues to threaten humanity due to the persistent emergence ...
Xi Lv, Xiancai Ma, Shiqi Xiao, Meilin Hu, Taizhen Liang, Guojie Li, Sen Liu, Ziyao Wu, Peiwen Li   +8 more
core   +1 more source

ACE-2-derived Biomimetic Peptides for the Inhibition of Spike Protein of SARS-CoV-2 [PDF]

, 2020
SARS-CoV-2, a novel coronavirus causing overwhelming death and infection worldwide, has emerged as a pandemic. Compared to its predecessor SARS-CoV, SARS-CoV-2 is more infective for being highly contagious and exhibiting tighter binding with host ...
Satyaranjan, Biswal, Saroj Kumar, Panda, Abhik Kumar, Ray, Parth Sarthi Sen, Gupta, Malay Kumar, Rana   +4 more
core   +1 more source

Mutation and Phylogenetic Analysis of Spike Glycoprotein of Indonesian Isolates of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2)

Majalah Kedokteran Bandung, 2021
Coronavirus disease-2019 (COVID-19) is an infectious acute respiratory disease caused by SARS-CoV-2. The protein that plays a role in the entry of SARS-CoV-2 into human cells is the surface protein, or the Spike, which is thought to be the effective ...
Shabarni Gaffar, Syifa Al Fauziah Rahmani, Ari Hardianto   +2 more
doaj   +1 more source

Virtual Screening of Curcumin and Its Analogs Against the Spike Surface Glycoprotein of SARS-CoV-2 and SARS-CoV [PDF]

, 2020
COVID-19, a new pandemic caused by SARS-CoV-2, was first identified in 2019 in Wuhan, China. The novel corona virus SARS-CoV-2 and the 2002 SARS-CoV have 74 % identity and use similar mechanisms to gain entry into the cell.
Suresh B, Pakala, Ashish, Shah, Harnisha, Patel, Malathi, Rajendran, Ashish, Patel, Prashanthi, Karyala   +5 more
core   +1 more source

SARS-CoV-2 and the spike protein in endotheliopathy

Trends in Microbiology
SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial compartment in the upper and lower airways. There is evidence that the microvasculature in both the pulmonary and extrapulmonary systems is a major target of SARS-CoV-2. Consistent with this, vascular dysfunction and thrombosis are the most severe complications in COVID-19 ...
Luca Perico, Ariela Benigni, Giuseppe Remuzzi   +2 more
openaire   +2 more sources

Neutralizing antibodies targeting SARS-CoV-2 spike protein

Stem Cell Research, 2021
SARS-CoV-2 causing the worldwide pandemic has changed people's life in multiple aspects dramatically since it's first identified in Wuhan, China at the end of 2019. While the numbers of infected patients and death toll keep vigorous increasing, curbing the progression of the pandemic is an urgent goal.
Xiaojie, Shi, Yu, Li, lei, Yan, Guang, Yang, Min, Qiang   +4 more
openaire   +3 more sources