Results 61 to 70 of about 131,065 (253)

Evaluating SARS-CoV-2 Spike Protein Transfection in HEK-293T Cells for VLP Applications

Journal of Experimental Life Science
The spike protein in SARS-CoV-2 works mainly to initiate infections, especially for binding to host cells and fusing with cell membranes. Characterizing SARS-CoV-2 spikes protein transfection cells could optimize the production of VLP in HEK-293T cells ...
Ilmiana Nurur Rohmah, Kavana Hafil Kusuma, Yuyun Ika Christina, Dinia Rizqi Dwijayanti, Dewi Mustikaningtyas, Nashi Widodo, Muhammad Sasmito Djati   +6 more
doaj   +1 more source

Mutation and Phylogenetic Analysis of Spike Glycoprotein of Indonesian Isolates of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2)

Majalah Kedokteran Bandung, 2021
Coronavirus disease-2019 (COVID-19) is an infectious acute respiratory disease caused by SARS-CoV-2. The protein that plays a role in the entry of SARS-CoV-2 into human cells is the surface protein, or the Spike, which is thought to be the effective ...
Shabarni Gaffar, Syifa Al Fauziah Rahmani, Ari Hardianto   +2 more
doaj   +1 more source

Purification and electron cryomicroscopy of coronavirus particles. [PDF]

, 2008
Intact, enveloped coronavirus particles vary widely in size and contour, and are thus refractory to study by traditional structural means such as X-ray crystallography. Electron microscopy (EM) overcomes some problems associated with particle variability
Adair, Brian D, Buchmeier, Michael J, Neuman, Benjamin W, Yeager, Mark   +3 more
core   +1 more source

The Elusive Coreceptors for the SARS-CoV-2 Spike Protein

Viruses, 2022
Evidence suggests that the N-terminal domain (NTD) of the SARS-CoV-2 spike protein interacts with host coreceptors that participate in viral entry. Resolving the identity of coreceptors has important clinical implications as it may provide the basis for the development of antiviral drugs and vaccine candidates.
Reed L. Berkowitz, David A. Ostrov
openaire   +3 more sources

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +8 more sources

Evolution of increased positive charge on the SARS-CoV-2 spike protein may be adaptation to human transmission

iScience, 2023
Summary: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and infect individuals. The exterior surface of the SARS-CoV-2 virion is dominated by the spike protein, and the current work examined spike protein biochemical
Matthew Cotten, My V.T. Phan
doaj   +1 more source

Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong.

, 2003
BACKGROUND: Health authorities worldwide, especially in the Asia Pacific region, are seeking effective public-health interventions in the continuing epidemic of severe acute respiratory syndrome (SARS).
Abu-Raddad, Laith J, Anderson, Roy M, Chan, King-Pan, Chau, Patsy, Donnelly, Christl A, Ferguson, Neil M, Fraser, Christophe, Ghani, Azra C, Hedley, Anthony J, Ho, Lai-Ming, Kong, James HB, Lam, Tai-Hing, Lau, Edith MC, Leung, Gabriel M, Liu, Shao-Haei, Riley, Steven, Thach, Thuan-Quoc, Tsang, Thomas, Tse, Lai-Yin   +18 more
core   +1 more source

Understanding Viral Transmission Behavior via Protein Intrinsic Disorder Prediction: Coronaviruses [PDF]

, 2012
Besides being a common threat to farm animals and poultry, coronavirus (CoV) was responsible for the human severe acute respiratory syndrome (SARS) epidemic in 2002-4. However, many aspects of CoV behavior, including modes of its transmission, are yet to
Dunker, A. Keith, Goh, Gerard Kian-Meng, Uversky, Vladmir N.   +2 more
core   +3 more sources

Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?

Frontiers in Cellular and Infection Microbiology, 2021
The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both of which ...
Christopher A. Beaudoin, Samir W. Hamaia, Christopher L.-H. Huang, Christopher L.-H. Huang, Tom L. Blundell, Antony P. Jackson   +5 more
doaj   +1 more source

Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions.

, 2003
We present an analysis of the first 10 weeks of the severe acute respiratory syndrome (SARS) epidemic in Hong Kong. The epidemic to date has been characterized by two large clusters-initiated by two separate "super-spread" events (SSEs)-and by ongoing ...
Abu-Raddad, Laith J, Anderson, Roy M, Chan, King-Pan, Chau, Patsy, Donnelly, Christl A, Ferguson, Neil M, Fraser, Christophe, Ghani, Azra C, Hedley, Anthony J, Ho, Lai-Ming, Ho, William, Lam, Tai-Hing, Lau, Edith MC, Lee, Koon-Hung, Leung, Gabriel M, Leung, Pak-Yin, Lo, Su-Vui, Riley, Steven, Thach, Thuan Q, Tsang, Thomas   +19 more
core   +1 more source