Results 81 to 90 of about 99,522,423 (293)
Journal of Infection and Public Health, 2023 Background: The SARS-CoV-2 pandemic, caused by the novel coronavirus, has posed a significant global health threat since its emergence in late 2019. The World Health Organization declared the outbreak a pandemic on March 11, 2020, due to its rapid global
Muhammad Zaheer +4 more
doaj +1 more source
Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2
, 2020 The outbreak of a novel coronavirus, which was later formally named the severe acute respiratory coronavirus 2 (SARS-CoV-2), has caused a worldwide public health crisis. Previous studies showed that SARS-CoV-2 is highly homologous to SARS-CoV and infects
Huanyu Tao +4 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
LRRC15 binds with spike proteins of SARS-CoV-2 variants and SARS-CoV-1.
, 2022 (A, B) A375 cells (A) or HeLa cells (B) were transduced with indicated activating sgRNAs and surface expression of LRRC15 and ACE2 was measured by flow cytometry. (C) HeLa cells were transduced with indicated activating sgRNAs and incubated with 100, 500,
Olin D. Liang (13955926) +10 more
core +1 more source
Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?
Frontiers in Cellular and Infection Microbiology, 2021 The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both of which ...
Christopher A. Beaudoin +5 more
doaj +1 more source
Identification of Conserved Epitopes in SARS-CoV-2 Spike and Nucleocapsid Protein [PDF]
Current Genomics, 2020 Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that first occurred in Wuhan in December 2019. The spike glycoproteins and nucleocapsid proteins are the most common targets for the development of vaccines and antiviral drugs.
Forcelloni S. +3 more
openaire +3 more sources
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathway
MedComm, 2021 SARS‐CoV‐2 is an enveloped positive‐sense RNA virus that depends on host factors for all stages of its life. Membrane receptor ACE2 is a well‐established factor for SARS‐CoV‐2 docking.
Lin Zhao +5 more
doaj +1 more source
Microorganisms, 2022 Currently, the world is struggling with the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
George Tetz, Victor Tetz
doaj +1 more source
Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection
FEBS Open Bio, EarlyView.Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow +12 more
wiley +1 more source