Results 11 to 20 of about 131,065 (253)

Distinct conformational states of SARS-CoV-2 spike protein [PDF]

Science, 2020
A dynamic viral spike Efforts to protect human cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the trimeric spike (S) protein. Several structures have shown a stabilized ectodomain of the spike in its prefusion conformation. Cai et al.
Yongfei Cai, Jun Zhang, Tianshu Xiao
exaly   +4 more sources

Mutations and Evolution of the SARS-CoV-2 Spike Protein

Viruses, 2022
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis
Nicholas Magazine, Tianyi Zhang, Yingying Wu, Michael C. McGee, Gianluca Veggiani, Weishan Huang   +5 more
doaj   +4 more sources

Amyloidogenesis of SARS-CoV-2 Spike Protein [PDF]

Journal of the American Chemical Society, 2021
ABSTRACTSARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 Spike protein (S-protein).
Sofie Nyström, Per Hammarström
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O-Glycosylation Landscapes of SARS-CoV-2 Spike Proteins [PDF]

Frontiers in Chemistry, 2021
The densely glycosylated spike (S) proteins that are highly exposed on the surface of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitate viral attachment, entry, and membrane fusion. We have previously reported all the 22  N -glycosites and site-specific
Yong Zhang, Wanjun Zhao, Yonghong Mao, Yaohui Chen, Shanshan Zheng, Wei Cao, Jingqiang Zhu, Liqiang Hu, Meng Gong, Jingqiu Cheng, Hao Yang   +10 more
openaire   +3 more sources

Expression and characterization of SARS-CoV-2 spike proteins [PDF]

Nature Protocols, 2021
The severe acute respiratory syndrome coronavirus 2 spike protein is a critical component of coronavirus disease 2019 vaccines and diagnostics and is also a therapeutic target. However, the spike protein is difficult to produce recombinantly because it is a large trimeric class I fusion membrane protein that is metastable and heavily glycosylated.
Jeffrey M. Schaub, Chia-Wei Chou, Hung-Che Kuo, Kamyab Javanmardi, Ching-Lin Hsieh, Jory Goldsmith, Andrea M. DiVenere, Kevin C. Le, Daniel Wrapp, Patrick O. Byrne, Christy K. Hjorth, Nicole V. Johnson, John Ludes-Meyers, Annalee W. Nguyen, Nianshuang Wang, Jason J. Lavinder, Gregory C. Ippolito, Jennifer A. Maynard, Jason S. McLellan, Ilya J. Finkelstein   +19 more
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Structure of SARS-CoV-2 spike protein

Current Opinion in Virology, 2021
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and devastating socio-economic consequences worldwide. The disease has created urgent needs for intervention strategies to control the crisis and meeting these needs requires a deep ...
Jun Zhang, Tianshu Xiao, Yongfei Cai, Bing Chen   +3 more
openaire   +2 more sources

SARS-CoV-2 Spike Protein Interaction Space

International Journal of Molecular Sciences, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a +sense single-strand RNA virus. The virus has four major surface proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N), respectively. The constitutive proteins present a high grade of symmetry. Identifying a binding site is difficult. The virion is approximately 50–200 nm
Claudiu N. Lungu, Mihai V. Putz
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A thermostable, closed, SARS-CoV-2 spike protein trimer [PDF]

Nature Structural & Molecular Biology, 2020
AbstractThe spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. S exhibits substantial conformational flexibility. It transitions from closed to open conformations to expose its receptor binding site, and subsequently from prefusion to postfusion conformations to mediate fusion of ...
Xiaoli Xiong, Kun Qu, Katarzyna A. Ciazynska, Myra Hosmillo, Andrew P. Carter, Soraya Ebrahimi, Zunlong Ke, Sjors H. W. Scheres, Laura Bergamaschi, Guinevere L. Grice, Ying Zhang, John Bradley, Paul A. Lyons, Kenneth G. C. Smith, Mark Toshner, Anne Elmer, Carla Ribeiro, Jenny Kourampa, Sherly Jose, Jane Kennet, Jane Rowlands, Anne Meadows, Criona O’Brien, Rebecca Rastall, Cherry Crucusio, Sarah Hewitt, Jane Price, Jo Calder, Laura Canna, Ashlea Bucke, Hugo Tordesillas, Julie Harris, Valentina Ruffolo, Jason Domingo, Barbara Graves, Helen Butcher, Daniela Caputo, Emma Le Gresley, Benjamin J. Dunmore, Jennifer Martin, Ekaterina Legchenko, Carmen Treacy, Christopher Huang, Jennifer Wood, Rachel Sutcliffe, Josh Hodgson, Joy Shih, Stefan Graf, Zhen Tong, Federica Mescia, Tobias Tilly, Ciara O’Donnell, Kelvin Hunter, Linda Pointon, Nicole Pond, Marta Wylot, Emma Jones, Stuart Fawke, Ben Bullman, Laura Bergamaschi, Lori Turner, Isobel Jarvis, Ommar Omarjee, Aloka De Sa, Joe Marsden, Ariana Betancourt, Marianne Perera, Maddie Epping, Nathan Richoz, Georgie Bower, Rahul Sharma, Francesca Nice, Oisin Huhn, Hannah Stark, Neil Walker, Kathy Stirrups, Nigel Ovington, Eleanor Dewhust, Emily Li, Sofia Papadia, James A. Nathan, Stephen Baker, Leo C. James, Helen E. Baxendale, Ian Goodfellow, Rainer Doffinger, John A. G. Briggs   +86 more
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SARS-CoV-2 Spike Protein Destabilizes Microvascular Homeostasis

Microbiology Spectrum, 2021
SARS-CoV-2 causes complex effects on microvascular homeostasis that potentially contribute to organ dysfunction and coagulopathies. SARS-CoV-2 binds to, and causes downregulation of angiotensin converting enzyme 2 (ACE2) on cells that it infects.
Soumya Panigrahi, Tamal Goswami, Brian Ferrari, Christopher J. Antonelli, Douglas A. Bazdar, Hannah Gilmore, Michael L. Freeman, Michael M. Lederman, Scott F. Sieg   +8 more
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Neutralizing antibodies targeting SARS-CoV-2 spike protein

Stem Cell Research, 2021
SARS-CoV-2 causing the worldwide pandemic has changed people's life in multiple aspects dramatically since it's first identified in Wuhan, China at the end of 2019. While the numbers of infected patients and death toll keep vigorous increasing, curbing the progression of the pandemic is an urgent goal.
Xiaojie, Shi, Yu, Li, lei, Yan, Guang, Yang, Min, Qiang   +4 more
openaire   +3 more sources