Results 11 to 20 of about 99,522,423 (293)

Mutations and Evolution of the SARS-CoV-2 Spike Protein [PDF]

Viruses, 2022
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis
Nicholas Magazine, Tianyi Zhang, Yingying Wu, Michael C. McGee, Gianluca Veggiani, Weishan Huang   +5 more
doaj   +5 more sources

TMPRSS11D and TMPRSS13 Activate the SARS-CoV-2 Spike Protein [PDF]

Viruses, 2021
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) utilizes host proteases, including a plasma membrane-associated transmembrane protease, serine 2 (TMPRSS2) to cleave and activate the virus spike protein to facilitate cellular entry.
Kishimoto, Mai, William W. Hall, Sanaki, Takao, Hiroaki Kariwa, Michihito Sasaki, Kariwa, Hiroaki, Akihiko Sato, Kentaro Uemura, Sasaki, Michihito, Mai Kishimoto, Sato, Akihiko, Orba, Yasuko, Uemura, Kentaro, Sawa, Hirofumi, Takao Sanaki, Hall, William W., Hirofumi Sawa, Yasuko Orba   +17 more
core   +6 more sources

SARS CoV-2 Spike Protein in silico Interaction With ACE2 Receptors From Wild and Domestic Species

Frontiers in Genetics, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a pandemic by the World Health Organization (WHO), and since its first report, it has become a major public health concern.
Santiago Rendon-Marin, Marlen Martinez-Gutierrez, Marlen Martinez-Gutierrez, Gary R. Whittaker, Javier A. Jaimes, Julian Ruiz-Saenz   +5 more
doaj   +2 more sources

Emergence of SARS‐CoV‐2 spike protein at the vaccination site

Immunity, Inflammation and Disease, 2023
Background The anti‐coronavirus disease 2019 (COVID‐19) vaccines are of paramount importance in the fight against the COVID‐19 pandemic. Both viral vector‐ and nucleic acid‐based vaccines are known to effectively induce protection against the severe ...
Annika Beck, Hanna Dietenberger, Sebastian N. Kunz, Kevin Mellert, Peter Möller   +4 more
doaj   +3 more sources

Amyloidogenesis of SARS-CoV-2 Spike Protein [PDF]

Journal of the American Chemical Society, 2021
ABSTRACT SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 Spike protein (S-protein).
Sofie Nyström, Per Hammarström
openaire   +2 more sources

Expression and characterization of SARS-CoV-2 spike proteins [PDF]

Nature Protocols, 2021
The severe acute respiratory syndrome coronavirus 2 spike protein is a critical component of coronavirus disease 2019 vaccines and diagnostics and is also a therapeutic target. However, the spike protein is difficult to produce recombinantly because it is a large trimeric class I fusion membrane protein that is metastable and heavily glycosylated.
Jeffrey M. Schaub, Chia-Wei Chou, Hung-Che Kuo, Kamyab Javanmardi, Ching-Lin Hsieh, Jory Goldsmith, Andrea M. DiVenere, Kevin C. Le, Daniel Wrapp, Patrick O. Byrne, Christy K. Hjorth, Nicole V. Johnson, John Ludes-Meyers, Annalee W. Nguyen, Nianshuang Wang, Jason J. Lavinder, Gregory C. Ippolito, Jennifer A. Maynard, Jason S. McLellan, Ilya J. Finkelstein   +19 more
openaire   +2 more sources

Binding of the SARS-CoV-2 spike protein to glycans [PDF]

Science Bulletin, 2020
Abstract The pandemic of SARS-CoV-2 has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing oligosaccharides.
Hao, Wei, Ma, Bo, Li, Ziheng, Wang, Xiaoyu, Gao, Xiaopan, Li, Yaohao, Qin, Bo, Shang, Shiying, Cui, Sheng, Tan, Zhongping   +9 more
openaire   +2 more sources

Structure of SARS-CoV-2 spike protein

Current Opinion in Virology, 2021
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and devastating socio-economic consequences worldwide. The disease has created urgent needs for intervention strategies to control the crisis and meeting these needs requires a deep ...
Jun Zhang, Tianshu Xiao, Yongfei Cai, Bing Chen   +3 more
openaire   +2 more sources

Evolution of the SARS-CoV-2 spike protein in the human host [PDF]

Nature Communications, 2021
Abstract Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins multiple substitutions associated with increased transmission and resistance to neutralising antibodies. We have examined the structure and receptor binding properties of spike proteins from the B.1.1.7 (Alpha) and B.1.351 (Beta) variants to ...
Antoni G. Wrobel, Donald J. Benton, Chloë Roustan, Annabel Borg, Saira Hussain, Stephen R. Martin, Peter B. Rosenthal, John J. Skehel, Steven J. Gamblin   +8 more
openaire   +4 more sources

The Elusive Coreceptors for the SARS-CoV-2 Spike Protein

Viruses, 2022
Evidence suggests that the N-terminal domain (NTD) of the SARS-CoV-2 spike protein interacts with host coreceptors that participate in viral entry. Resolving the identity of coreceptors has important clinical implications as it may provide the basis for the development of antiviral drugs and vaccine candidates.
Reed L. Berkowitz, David A. Ostrov
openaire   +3 more sources