Results 11 to 20 of about 90,748 (118)

Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein

Frontiers in Immunology, 2021
The outbreak and worldwide pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a significant impact on global economy and human health. In order to reduce the disease spread, 16 monoclonal antibodies (McAbs) again SARS-
Ge Li, Ge Li, Aiping Wang, Yumei Chen, Yaning Sun, Yongkun Du, Xun Wang, Peiyang Ding, Rui Jia, Yanwei Wang, Gaiping Zhang, Gaiping Zhang   +11 more
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Sars-Cov-2 And Betacoronavirus: What Have We Learned In 8 Months?

Postępy Mikrobiologii, 2020
In 2019, a new human pandemic coronavirus (SARS-CoV-2) emerged in Wuhan, China. We present the knowledge about SARS-CoV-2 compared to SARS-CoV and MERS-CoV. The SARS-CoV-2 is similar to other coronaviruses, nevertheless, differences were observed.
Kwiatek Agnieszka, Adamczyk-Popławska Monika   +1 more
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Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses

iScience, 2022
Summary: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses continuous challenges in combating the virus. Here, we describe vaccination strategies to broaden SARS-CoV-2 and sarbecovirus immunity by combining ...
Mitch Brinkkemper, Tim S. Veth, Philip J.M. Brouwer, Hannah Turner, Meliawati Poniman, Judith A. Burger, Joey H. Bouhuijs, Wouter Olijhoek, Ilja Bontjer, Jonne L. Snitselaar, Tom G. Caniels, Cynthia A. van der Linden, Rashmi Ravichandran, Julien Villaudy, Yme U. van der Velden, Kwinten Sliepen, Marit J. van Gils, Andrew B. Ward, Neil P. King, Albert J.R. Heck, Rogier W. Sanders   +20 more
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Possible inhibition of GM-CSF production by SARS-CoV-2 spike-based vaccines

Molecular Medicine, 2021
A SARS-like coronavirus 2 (SARS-CoV-2) has caused a pandemic Coronavirus Disease 2019 (COVID-19) that killed more than 3.3 million people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of its spike protein to bind a ...
Jianhua Li, Ping Wang, Kevin J. Tracey, Haichao Wang   +3 more
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BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein

Frontiers in Immunology, 2022
Since first reported in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly acquiring mutations, particularly in the spike protein, that can modulate pathogenicity, transmission and antibody evasion leading to successive waves ...
Mohanraj Manangeeswaran, Derek D. C. Ireland, Seth G. Thacker, Ha-Na Lee, Logan Kelley-Baker, Aaron P. Lewkowicz, Paul W. Rothlauf, Paul W. Rothlauf, Marjorie Cornejo Pontelli, Louis-Marie Bloyet, Michael A. Eckhaus, Mirian I. Mendoza, Sean Whelan, Daniela Verthelyi   +13 more
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SARS-CoV-2 spike-protein targeted serology test results and their association with subsequent COVID-19-related outcomes

Frontiers in Public Health, 2023
ImportanceIn the absence of evidence of clinical utility, the United States' Centers for Disease Control and Prevention does not currently recommend the assessment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) spike-protein antibody ...
Harvey W. Kaufman, Stanley Letovsky, William A. Meyer, Laura Gillim, Magdalene M. Assimon, Carly A. Kabelac, John W. Kroner, Shannon L. Reynolds, Marcia Eisenberg   +8 more
doaj   +1 more source

Analysis of SARS-CoV-2 Spike Protein as The Key Target in the Development of Antiviral Candidates for COVID-19 through Computational Study

Journal of Tropical Pharmacy and Chemistry, 2021
The recent public health crisis is threatening the world with the emergence of the spread of the new coronavirus 2019 (2019-nCoV) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Taufik Muhammad Fakih, Mentari Luthfika Dewi   +1 more
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Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike Protein

Frontiers in Chemistry, 2021
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still an emergent pandemic for humans. The virus infection is achieved by penetrating its spike protein to host cells via binding with ACE2.
Bingqian Li, Bingqian Li, Lin Wang, Huan Ge, Xianglei Zhang, Penxuan Ren, Yu Guo, Wuyan Chen, Jie Li, Wei Zhu, Wenzhang Chen, Lili Zhu, Fang Bai   +12 more
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Protocol to isolate and assess spike protein cleavage in SARS-CoV-2 variants obtained from clinical COVID-19 samples

STAR Protocols, 2022
Summary: For efficient cell entry, SARS-CoV-2 spike protein needs to be cleaved by cellular proteases. Here, we present a comprehensive protocol to assess SARS-CoV-2 spike protein cleavage in viral supernatants from SARS-CoV-2-infected cells.
Alba Escalera, Adolfo García-Sastre, Teresa Aydillo   +2 more
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SARS CoV-2 Spike Protein in silico Interaction With ACE2 Receptors From Wild and Domestic Species

Frontiers in Genetics, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been declared a pandemic by the World Health Organization (WHO), and since its first report, it has become a major public health concern.
Santiago Rendon-Marin, Marlen Martinez-Gutierrez, Marlen Martinez-Gutierrez, Gary R. Whittaker, Javier A. Jaimes, Julian Ruiz-Saenz   +5 more
doaj   +1 more source