Results 21 to 30 of about 99,522,423 (293)

N- and O-Glycosylation of the SARS-CoV-2 Spike Protein [PDF]

Analytical Chemistry, 2020
ABSTRACT Covid-19 pandemic outbreak is the reason of the current world health crisis. The development of effective antiviral compounds and vaccines requires detailed descriptive studies of the SARS-CoV-2 proteins. The SARS-CoV-2 spike (S) protein mediates virion binding to the human cells through its interaction with the ACE2 cell ...
Sanda, Miloslav, Morrison, Lindsay, Goldman, Radoslav   +2 more
openaire   +4 more sources

The SARS-CoV-2 spike protein: balancing stability and infectivity [PDF]

Cell Research, 2020
SARS-CoV-2 spike (S) glycoprotein is the key target of current vaccine development efforts to combat COVID-19; neutralizing antibodies bind S and interfere with S binding to its receptor, angiotensin-converting enzyme 2. Recent work reveals the molecular basis of increased infectivity of the globally prevailing D614G S mutation.
Berger, Imre, Schaffitzel, Christiane
openaire   +3 more sources

A thermostable, closed, SARS-CoV-2 spike protein trimer [PDF]

Nature Structural & Molecular Biology, 2020
Abstract The spike (S) protein of SARS-CoV-2 mediates receptor binding and cell entry and is the dominant target of the immune system. S exhibits substantial conformational flexibility. It transitions from closed to open conformations to expose its receptor binding site, and subsequently from prefusion to postfusion conformations to ...
Xiong, X., Qu, K., Ciazynska, K., Hosmillo, M., Carter, A., Ebrahimi, S., Ke, Z., Scheres, S., Bergamaschi, L., Grice, G., Zhang, Y., Nathan, J., Baker, S., James, L., Baxendale, H., Goodfellow, I., Doffinger, R., Briggs, J., Bradley, J., Lyons, P., Smith, K., Toshner, M., Elmer, A., Ribeiro, C., Kourampa, J., Jose, S., Kennet, J., Rowlands, J., Meadows, A., O'Brien, C., Rastall, R., Crucusio, C., Hewitt, S., Price, J., Calder, J., Laura, C., Bucke, A., Tordesillas, H., Harris, J., Ruffolo, V., Domingo, J., Graves, B., Butcher, H., Caputo, D., Le Gresley, E., Dunmore, B., Martin, J., Legchenko, E., Treacy, C., Huang, C., Wood, J., Sutcliffe, R., Hodgson, J., Shih, J., Graf, S., Tong, Z., Mescia, F., Tilly, T., O'Donnell, C., Hunter, K., Pointon, L., Pond, N., Wylot, M., Jones, E., Fawke, S., Bullman, B., Bergamaschi, L., Turner, L., Jarvis, I., Omarjee, O., De Sa, A., Marsden, J., Betancourt, A., Perera, M., Epping, M., Richoz, N., Bower, G., Sharma, R., Nice, F., Huhn, O., Stark, H., Walker, N., Stirrups, K., Ovington, N., Dewhust, E., Li, E., Papadia, S., C, C.   +87 more
openaire   +5 more sources

SARS-CoV-2 Spike Protein Interaction Space

International Journal of Molecular Sciences, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a +sense single-strand RNA virus. The virus has four major surface proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N), respectively. The constitutive proteins present a high grade of symmetry. Identifying a binding site is difficult. The virion is approximately 50–200 nm
Claudiu N. Lungu, Mihai V. Putz
openaire   +2 more sources

O-Glycosylation Landscapes of SARS-CoV-2 Spike Proteins [PDF]

Frontiers in Chemistry, 2021
The densely glycosylated spike (S) proteins that are highly exposed on the surface of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) facilitate viral attachment, entry, and membrane fusion. We have previously reported all the 22  N -glycosites and site-specific
Yong Zhang, Wanjun Zhao, Yonghong Mao, Yaohui Chen, Shanshan Zheng, Wei Cao, Jingqiang Zhu, Liqiang Hu, Meng Gong, Jingqiu Cheng, Hao Yang   +10 more
openaire   +3 more sources

SARs-Cov-2 spike protein and ACE2

, 2022
Model built as part of a collaborative molecular simulation SARS-COv-2 project investigating the interactions between the SARS-CoV-2 spike protein and ACE2 protein, each component being embedded in its lipid bilayer.
Laurent Chaloin (12269174), Serge Perez (12091370), Bernard Maigret (12269172)   +2 more
core   +1 more source

Distinct conformational states of SARS-CoV-2 spike protein [PDF]

Science, 2020
A dynamic viral spike Efforts to protect human cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the trimeric spike (S) protein. Several structures have shown a stabilized ectodomain of the spike in its prefusion conformation. Cai et al.
Yongfei Cai, Jun Zhang, Tianshu Xiao, Hanqin Peng, Sarah M. Sterling, Richard M. Walsh, Shaun Rawson, Sophia Rits-Volloch, Bing Chen   +8 more
openaire   +3 more sources

Allosteric Regulation of SARS-CoV-2 Spike Protein Revealed by Contrastive Machine Learning [PDF]

, 2023
Allosteric regulation is common in protein-protein interactions and thus can be used in drug design. Nevertheless, the mechanism of allosteric regulation remains elusive for most proteins, including SARS-CoV-2 spike protein, despite extensive ...
Tao, Wei, Yong, Wei, Amy, Chen, Yuewei, Lin, Baofu, Qiao, Tao Wei, Amy Chen, Yong Wei, Baofu Qiao, Yuewei Lin   +9 more
core   +1 more source

Sars-Cov-2 And Betacoronavirus: What Have We Learned In 8 Months?

Postępy Mikrobiologii, 2020
In 2019, a new human pandemic coronavirus (SARS-CoV-2) emerged in Wuhan, China. We present the knowledge about SARS-CoV-2 compared to SARS-CoV and MERS-CoV. The SARS-CoV-2 is similar to other coronaviruses, nevertheless, differences were observed.
Kwiatek Agnieszka, Adamczyk-Popławska Monika   +1 more
doaj   +1 more source

Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses

iScience, 2022
Summary: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses continuous challenges in combating the virus. Here, we describe vaccination strategies to broaden SARS-CoV-2 and sarbecovirus immunity by combining ...
Mitch Brinkkemper, Tim S. Veth, Philip J.M. Brouwer, Hannah Turner, Meliawati Poniman, Judith A. Burger, Joey H. Bouhuijs, Wouter Olijhoek, Ilja Bontjer, Jonne L. Snitselaar, Tom G. Caniels, Cynthia A. van der Linden, Rashmi Ravichandran, Julien Villaudy, Yme U. van der Velden, Kwinten Sliepen, Marit J. van Gils, Andrew B. Ward, Neil P. King, Albert J.R. Heck, Rogier W. Sanders   +20 more
doaj   +1 more source