Results 21 to 30 of about 131,065 (253)

SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination [PDF]

Cell Death & Differentiation, 2021
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is highly contagious and causes lymphocytopenia, but the underlying mechanisms are poorly understood. We demonstrate here that heterotypic cell-in-cell structures with lymphocytes inside multinucleate syncytia are prevalent in the lung tissues of coronavirus disease
Qiang Sun, Zhengrong Zhang, You Zheng, Zubiao Niu, Bo Zhang, Chenxi Wang, Xiao-Hong Yao, Haoran Peng, Franca Del Nonno, Yunyun Wang, Yichao Zhu, Yan Su, Meng Tang, Xiaoyi Jiang, He Ren, Meifang He, Yuqi Wang, Li-Hua Gao, Ping Zhao, Hanping Shi, Xiao-ning Wang, Zhaolie Chen, Mauro Piacentini, Xiu-Wu Bian, Gerry Melino, Liang Liu, Hongyan Huang   +26 more
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Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity

Cells, 2023
Cardiovascular complications are major clinical hallmarks of acute and post-acute coronavirus disease 2019 (COVID-19). However, the mechanistic details of SARS-CoV-2 infectivity of endothelial cells remain largely unknown. Here, we demonstrate that the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein shares a similarity with the ...
Nader Rahimi, Mitchell R. White, Razie Amraei, Saran Lotfollahzadeh, Chaoshuang Xia, Marek Michalak, Catherine E. Costello, Elke Mühlberger   +7 more
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CpG-adjuvanted stable prefusion SARS-CoV-2 spike protein protected hamsters from SARS-CoV-2 challenge [PDF]

Scientific Reports, 2021
Abstract The COVID-19 pandemic presents an unprecedented challenge to global public health. Rapid development and deployment of safe and effective vaccines are imperative to control the pandemic. In the current study, we applied our adjuvanted stable prefusion SARS-CoV-2 spike (S-2P)-based vaccine, MVC-COV1901, to hamster models to ...
Chia-En Lien, Yi-Jiun Lin, Charles Chen, Wei-Cheng Lian, Tsun-Yung Kuo, John D. Campbell, Paula Traquina, Meei-Yun Lin, Luke Tzu-Chi Liu, Ya-Shan Chuang, Hui-Ying Ko, Chun-Che Liao, Yen-Hui Chen, Jia-Tsrong Jan, Hsiu-Hua Ma, Cheng-Pu Sun, Yin-Shiou Lin, Ping-Yi Wu, Yu-Chiuan Wang, Mi-Hua Tao, Yi-Ling Lin   +20 more
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Sars-Cov-2 And Betacoronavirus: What Have We Learned In 8 Months?

Postępy Mikrobiologii, 2020
In 2019, a new human pandemic coronavirus (SARS-CoV-2) emerged in Wuhan, China. We present the knowledge about SARS-CoV-2 compared to SARS-CoV and MERS-CoV. The SARS-CoV-2 is similar to other coronaviruses, nevertheless, differences were observed.
Kwiatek Agnieszka, Adamczyk-Popławska Monika   +1 more
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Possible inhibition of GM-CSF production by SARS-CoV-2 spike-based vaccines

Molecular Medicine, 2021
A SARS-like coronavirus 2 (SARS-CoV-2) has caused a pandemic Coronavirus Disease 2019 (COVID-19) that killed more than 3.3 million people worldwide. Like the SARS-CoV, SARS-CoV-2 also employs a receptor-binding motif (RBM) of its spike protein to bind a ...
Jianhua Li, Ping Wang, Kevin J. Tracey, Haichao Wang   +3 more
doaj   +1 more source

SARS-CoV-2 Spike protein alters microglial purinergic signaling

Frontiers in Immunology, 2023
Despite long-term sequelae of COVID-19 are emerging as a substantial public health concern, the mechanism underlying these processes still unclear. Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of viral brain replication resulting in activation of pattern recognition receptors (PRRs) and ...
Vinícius Santos Alves, Stephanie Alexia Cristina Silva Santos, Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Renata Rodrigues dos Reis, Mariana L. Calazans, Gabriel Gripp Fernandes, Leticia Silva Antônio, Emanuelle V. de Lima, Eleonora Kurtenbach, Jerson Lima Silva, Fabricia Lima Fontes-Dantas, Fabricia Lima Fontes-Dantas, Giselle Fazzioni Passos, Cláudia Pinto Figueiredo, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +16 more
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Co-display of diverse spike proteins on nanoparticles broadens sarbecovirus neutralizing antibody responses

iScience, 2022
Summary: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants poses continuous challenges in combating the virus. Here, we describe vaccination strategies to broaden SARS-CoV-2 and sarbecovirus immunity by combining ...
Mitch Brinkkemper, Tim S. Veth, Philip J.M. Brouwer, Hannah Turner, Meliawati Poniman, Judith A. Burger, Joey H. Bouhuijs, Wouter Olijhoek, Ilja Bontjer, Jonne L. Snitselaar, Tom G. Caniels, Cynthia A. van der Linden, Rashmi Ravichandran, Julien Villaudy, Yme U. van der Velden, Kwinten Sliepen, Marit J. van Gils, Andrew B. Ward, Neil P. King, Albert J.R. Heck, Rogier W. Sanders   +20 more
doaj   +1 more source

SARS-CoV-2 Spike Protein Activates Human Lung Macrophages

International Journal of Molecular Sciences, 2023
COVID-19 is a viral disease caused by SARS-CoV-2. This disease is characterized primarily, but not exclusively, by respiratory tract inflammation. SARS-CoV-2 infection relies on the binding of spike protein to ACE2 on the host cells. The virus uses the protease TMPRSS2 as an entry activator.
Francesco Palestra, Remo Poto, Renato Ciardi, Giorgia Opromolla, Agnese Secondo, Valentina Tedeschi, Anne Lise Ferrara, Rosa Maria Di Crescenzo, Maria Rosaria Galdiero, Leonardo Cristinziano, Luca Modestino, Gianni Marone, Alfonso Fiorelli, Gilda Varricchi, Stefania Loffredo   +14 more
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Proteolytic activation of SARS‐CoV‐2 spike protein

Microbiology and Immunology, 2021
AbstractSpike (S) protein cleavage is a crucial step in coronavirus infection. In this review, this process is discussed, with particular focus on the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Compared with influenza virus and paramyxovirus membrane fusion proteins, the cleavage activation mechanism of coronavirus
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Human SARS CoV ‐2 spike protein mutations [PDF]

Proteins: Structure, Function, and Bioinformatics, 2020
Abstract The human spike protein sequences from Asia, Africa, Europe, North America, South America, and Oceania were analyzed by comparing with the reference severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) protein sequence from Wuhan‐Hu‐1, China.
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