Results 21 to 30 of about 90,748 (118)

A method for the generation of pseudovirus particles bearing SARS coronavirus spike protein in high yields

Cell Structure and Function, 2022
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has threatened human health and the global economy. Development of additional vaccines and therapeutics is urgently required, but such development with live virus must be ...
Yoichiro Fujioka, Sayaka Kashiwagi, Aiko Yoshida, Aya O. Satoh, Mari Fujioka, Maho Amano, Yohei Yamauchi, Yusuke Ohba   +7 more
doaj   +1 more source

Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus

Heliyon, 2023
The human infectious disease COVID-19 caused by the SARS-CoV-2 virus has become a major threat to global public health. Developing a vaccine is the preferred prophylactic response to epidemics and pandemics.
Nancy E. Hernandez, Wojciech Jankowski, Rahel Frick, Simon P. Kelow, Joseph H. Lubin, Vijaya Simhadri, Jared Adolf-Bryfogle, Sagar D. Khare, Roland L. Dunbrack, Jr., Jeffrey J. Gray, Zuben E. Sauna   +10 more
doaj   +1 more source

SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells

Cell Discovery, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2) as a binding receptor to enter cells via clathrin-mediated endocytosis (CME).
Jinliang Wang, Guan Yang, Xinxin Wang, Zhiyuan Wen, Lei Shuai, Jie Luo, Chong Wang, Ziruo Sun, Renqiang Liu, Jinying Ge, Xijun He, Ronghong Hua, Xijun Wang, Xiao Yang, Weiye Chen, Gongxun Zhong, Zhigao Bu   +16 more
doaj   +1 more source

Evaluating SARS-CoV-2 Spike Protein Transfection in HEK-293T Cells for VLP Applications

Journal of Experimental Life Science
The spike protein in SARS-CoV-2 works mainly to initiate infections, especially for binding to host cells and fusing with cell membranes. Characterizing SARS-CoV-2 spikes protein transfection cells could optimize the production of VLP in HEK-293T cells ...
Ilmiana Nurur Rohmah, Kavana Hafil Kusuma, Yuyun Ika Christina, Dinia Rizqi Dwijayanti, Dewi Mustikaningtyas, Nashi Widodo, Muhammad Sasmito Djati   +6 more
doaj   +1 more source

Mutation and Phylogenetic Analysis of Spike Glycoprotein of Indonesian Isolates of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2)

Majalah Kedokteran Bandung, 2021
Coronavirus disease-2019 (COVID-19) is an infectious acute respiratory disease caused by SARS-CoV-2. The protein that plays a role in the entry of SARS-CoV-2 into human cells is the surface protein, or the Spike, which is thought to be the effective ...
Shabarni Gaffar, Syifa Al Fauziah Rahmani, Ari Hardianto   +2 more
doaj   +1 more source

Evolution of increased positive charge on the SARS-CoV-2 spike protein may be adaptation to human transmission

iScience, 2023
Summary: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve and infect individuals. The exterior surface of the SARS-CoV-2 virion is dominated by the spike protein, and the current work examined spike protein biochemical
Matthew Cotten, My V.T. Phan
doaj   +1 more source

Uncovering the impact of SARS-CoV2 spike protein variants on human receptors: A molecular dynamics docking and simulation approach

Journal of Infection and Public Health, 2023
Background: The SARS-CoV-2 pandemic, caused by the novel coronavirus, has posed a significant global health threat since its emergence in late 2019. The World Health Organization declared the outbreak a pandemic on March 11, 2020, due to its rapid global
Muhammad Zaheer, Nouman Ali, Hasnain Javed, Rimsha Munir, Nazia Jamil   +4 more
doaj   +1 more source

SARS-CoV-2 Spike Protein Stimulates Macropinocytosis in Murine and Human Macrophages via PKC-NADPH Oxidase Signaling

Antioxidants
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While recent studies have demonstrated that SARS-CoV-2 may enter kidney and colon epithelial cells by inducing receptor ...
WonMo Ahn, Faith N. Burnett, Ajay Pandey, Pushpankur Ghoshal, Bhupesh Singla, Abigayle B. Simon, Cassandra C. Derella, Stephen A. Addo, Ryan A. Harris, Rudolf Lucas, Gábor Csányi   +10 more
doaj   +1 more source

T cell epitopes of SARS-CoV-2 spike protein and conserved surface protein of Plasmodium malariae share sequence homology

Open Life Sciences, 2021
Since its emergence in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been spreading remarkably fast worldwide. Effective countermeasures require the rapid development of data and tools to monitor its spread and better ...
Hassan Md. Mehedi, Sharmin Shirina, Hong Jinny, Lee Hoi-Seon, Kim Hyeon-Jin, Hong Seong-Tshool   +5 more
doaj   +1 more source

Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?

Frontiers in Cellular and Infection Microbiology, 2021
The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both of which ...
Christopher A. Beaudoin, Samir W. Hamaia, Christopher L.-H. Huang, Christopher L.-H. Huang, Tom L. Blundell, Antony P. Jackson   +5 more
doaj   +1 more source