Results 11 to 20 of about 3,974,865 (310)
Cells, 2021 Coronaviruses such as SARS-CoV-2, which is responsible for COVID-19, depend on virus spike protein binding to host cell receptors to cause infection. The SARS-CoV-2 spike protein binds primarily to ACE2 on target cells and is then processed by membrane ...
Lynda J. Partridge +5 more
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Carbohydrate Ligands for COVID-19 Spike Proteins [PDF]
Viruses, 2022 An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has caused more than 340 million confirmed cases and 5.57 million deaths as of 23 January 2022 ...
Yung-Kuo Lee +7 more
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International Journal of Molecular Sciences, 2023 Several studies report elevated blood platelet activation and altered platelet count in COVID-19 patients, but the role of the SARS-CoV-2 spike protein in this process remains intriguing.
Boguslawa Luzak +13 more
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SARS-CoV-2 spike protein exerts an anti-cancer effect in A549 cells in association with MEG3 and BCYRN1 regulation [PDF]
Scientific ReportsFew studies have reported that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein may suppress cancer cell growth. Here, we investigated the effect of the SARS-CoV-2 spike protein in A549 lung cancer cells using recombinant spike ...
Jung-Eun Kim +4 more
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Fluorescent Glycan Fingerprinting of SARS2 Spike Proteins [PDF]
Scientific Reports, 2021 Abstract Glycosylation is the most common post-translational modification and has myriad biological functions. However, glycan analysis and research has always been a challenge. Here, we would like to present new techniques of glycan fingerprinting based on enzymatic fluorescent labeling and gel electrophoresis.
Zhengliang L Wu, James M Ertelt
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Mutations in the SARS CoV2 Spike Gene and Their Reflections on the Spike Protein
Clinical and Experimental Health Sciences, 2021 Objective: In this study, it was aimed to determine the mutation frequency in spike (S) genes of SARS CoV2 from six different regions of the world, their distribution on the gene and reflections of these mutations to the S protein. Materials and methods: SARS CoV2 S gene sequences originating from Asia, Africa, Europe, South America, Oceania and North ...
ÇAĞLAYAN, Elif, TURAN, Kadir
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Omicron Spike Protein is Vulnerable to Reduction
Journal of Molecular Biology, 2023 Abstract SARS-CoV-2 virus spike (S) protein is an envelope protein responsible for binding to the ACE2 receptor, driving subsequent entry into host cells. The existence of multiple disulfide bonds in the S protein makes it potentially susceptible to reductive cleavage.
Zhong Yao +10 more
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Current Research in Structural Biology, 2022 The comparison of 303,250 human SARS-CoV-2 spike protein sequences with the reference protein sequence Wuhan-Hu-1, showed ∼96.5% of the spike protein sequence has undergone the mutations till date, since outbreak of the COVID-19 pandemic disease that was
Kunchur Guruprasad
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Allosteric Regulation of SARS-CoV-2 Spike Protein Revealed by Contrastive Machine Learning [PDF]
, 2023 Allosteric regulation is common in protein-protein interactions and thus can be used in drug design. Nevertheless, the mechanism of allosteric regulation remains elusive for most proteins, including SARS-CoV-2 spike protein, despite extensive ...
Tao, Wei +9 more
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Frontiers in Microbiology, 2022 COVID-19 is currently global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Accompanying the rapid spread of the error-prone RNA-based genome, several dominant SARS-CoV-2 variants have been genetically identified.
Jen-Mei Chou +13 more
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