Results 11 to 20 of about 7,152,333 (341)
Distinct conformational states of SARS-CoV-2 spike protein
Science, 2020 A dynamic viral spike Efforts to protect human cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the trimeric spike (S) protein.
Yongfei Cai +8 more
semanticscholar +3 more sources
Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine
New England Journal of Medicine, 2020 Background NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins and Matrix-M1 adjuvant.
C. Keech +28 more
semanticscholar +3 more sources
Carbohydrate Ligands for COVID-19 Spike Proteins [PDF]
Viruses, 2022 An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has caused more than 340 million confirmed cases and 5.57 million deaths as of 23 January 2022 ...
Yung-Kuo Lee +7 more
doaj +3 more sources
Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion
Nature, 2020 Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by virus binding to the ACE2 cell-surface receptors 1 – 4 , followed by fusion of the virus and cell membranes to release the virus genome into the cell.
D. Benton +7 more
semanticscholar +3 more sources
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies
Cell, 2021 Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein prevent SARS-CoV-2 infection. However, the effects of antibodies against other spike protein domains are largely unknown.
Yafei Liu +36 more
semanticscholar +3 more sources
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity [PDF]
Nature Communications, 2020 SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (SG614) with the original (SD614).
Lizhou Zhang +14 more
semanticscholar +4 more sources
Fluorescent Glycan Fingerprinting of SARS2 Spike Proteins [PDF]
Scientific Reports, 2021 AbstractGlycosylation is the most common post-translational modification and has myriad biological functions. However, glycan analysis and research has always been a challenge. Here, we would like to present new techniques of glycan fingerprinting based on enzymatic fluorescent labeling and gel electrophoresis. The method is illustrated on SARS-2 spike
Zhengliang L Wu, James M Ertelt
openaire +4 more sources
Amyloidogenesis of SARS-CoV-2 Spike Protein [PDF]
Journal of the American Chemical Society, 2021 ABSTRACTSARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 Spike protein (S-protein).
Sofie Nyström, Per Hammarström
openaire +2 more sources
Enhancing epitope of PEDV spike protein
Frontiers in Microbiology, 2022 Porcine epidemic diarrhea virus (PEDV) is the causative agent of a highly contagious enteric disease of pigs characterized by diarrhea, vomiting, and severe dehydration. PEDV infects pigs of all ages, but neonatal pigs during the first week of life are highly susceptible; the mortality rates among newborn piglets may reach 80–100%.
Techit Thavorasak +13 more
openaire +3 more sources
Omicron Spike Protein is Vulnerable to Reduction
Journal of Molecular Biology, 2023 AbstractSARS-CoV-2 virus spike (S) protein is an envelope protein responsible for binding to the ACE2 receptor, driving subsequent entry into host cells. The existence of multiple disulfide bonds in the S protein makes it potentially susceptible to reductive cleavage.
Zhong Yao +10 more
openaire +2 more sources