Results 31 to 40 of about 7,075,307 (355)

SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice

Cell Reports, 2023
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019 (COVID-19) syndrome, but its underlying mechanisms are not completely understood.
F. Fontes-Dantas, G. Fernandes, E. G. Gutman, E. D. de Lima, Leticia S Antonio, Mariana B. Hammerle, H. P. Mota-Araujo, Lilian C. Colodeti, Suzana M. B. Araújo, Gabrielle M. Froz, Talita N. da Silva, L. Duarte, A. Salvio, K. Pires, L. Leon, C. C. F. Vasconcelos, L. Romão, L. Savio, Jerson L Silva, Robson da Costa, J. Clarke, A. D. da Poian, S. Alves‐Leon, G. Passos, C. Figueiredo   +24 more
semanticscholar   +1 more source

Spike-Fusion protein similarity region on spike protein.

, 2021
SARS-CoV-2 spike schematic model with paramyxovirus sequence similarity region shown with pale blue bar (residues 810 to 1098) (a). Corresponding area is shown in red on SARS-CoV-2 spike 3D structure (b).
Ehsan Ahmadi (2804020), Farshid Noorbakhsh (3843898), Mohammad Reza Zabihi (11785719), Ramin Hosseinzadeh (11785722), Leila Mohamed Khosroshahi (11785725)   +4 more
core   +1 more source

Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations

Frontiers in Chemistry, 2021
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). As of October 21, 2020, more than 41.4 million confirmed cases and 1.1 million deaths have been reported.
Sugunadevi Sakkiah, Wenjing Guo, Bohu Pan, Zuowei Ji, Gokhan Yavas, Marli Azevedo, Jessica Hawes, Tucker A. Patterson, Huixiao Hong   +8 more
doaj   +1 more source

In silico evaluation of the interaction between ACE2 and SARS-CoV-2 Spike protein in a hyperglycemic environment

Scientific Reports, 2021
The worse outcome of COVID-19 in people with diabetes mellitus could be related to the non-enzymatic glycation of human ACE2, leading to a more susceptible interaction with virus Spike protein.
Giovanni Sartore, Davide Bassani, Eugenio Ragazzi, Pietro Traldi, Annunziata Lapolla, Stefano Moro   +5 more
doaj   +1 more source

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Cell Research, 2020
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health.
Shuai Xia, Meiqin Liu, Chao Wang, W. Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, L. Bao, L. Du, Shuwen Liu, C. Qin, Fei Sun, Zhènglì Shí, Yun Zhu, Shibo Jiang, Lu Lu   +15 more
semanticscholar   +1 more source

A Fusion Peptide in the Spike Protein of MERS Coronavirus [PDF]

Viruses, 2019
Coronaviruses represent current and emerging threats for many species, including humans. Middle East respiratory syndrome-related coronavirus (MERS-CoV) is responsible for sporadic infections in mostly Middle Eastern countries, with occasional transfer elsewhere.
Entedar A. J. Alsaadi, Benjamin W. Neuman, Ian M. Jones   +2 more
openaire   +4 more sources

Amyloidogenesis of SARS-CoV-2 Spike Protein [PDF]

Journal of the American Chemical Society, 2021
ABSTRACT SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 Spike protein (S-protein).
Sofie Nyström, Per Hammarström
openaire   +2 more sources

Production and secretion of functional SARS-CoV-2 spike protein in Chlamydomonas reinhardtii

Frontiers in Plant Science, 2022
The spike protein is the major protein on the surface of coronaviruses. It is therefore the prominent target of neutralizing antibodies and consequently the antigen of all currently admitted vaccines against SARS-CoV-2.
Anna Maria Kiefer, Justus Niemeyer, Anna Probst, Gerhard Erkel, Michael Schroda   +4 more
doaj   +1 more source

Targeting the Interaction Between Spike Protein and Nucleocapsid Protein for Suppression and Detection of Human Coronavirus OC43

Frontiers in Immunology, 2022
Human coronavirus OC43 (HCoV-OC43) is the coronavirus most associated with “common colds”, infections of the upper respiratory tract. Previously, we reported that direct interactions of nucleocapsid (N) protein and C-terminal domain of Spike protein ...
Jinsoo Kim, Minyoung Kim, Dongbum Kim, Sangkyu Park, Mijeong Kang, Kyeongbin Baek, Jun-Kyu Choi, Sony Maharjan, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwon, Hyung-Joo Kwon   +11 more
doaj   +1 more source

Distinct conformational states of SARS-CoV-2 spike protein

Science, 2020
A dynamic viral spike Efforts to protect human cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the trimeric spike (S) protein.
Yongfei Cai, Jun Zhang, T. Xiao, Hanqin Peng, Sarah M. Sterling, R. M. Walsh, S. Rawson, Sophia Rits-Volloch, Bing Chen   +8 more
semanticscholar   +1 more source