Results 31 to 40 of about 7,152,333 (341)

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Cell Research, 2020
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health.
Shuai Xia, Meiqin Liu, Chao Wang, W. Xu, Qiaoshuai Lan, Siliang Feng, Feifei Qi, L. Bao, L. Du, Shuwen Liu, C. Qin, Fei Sun, Zhènglì Shí, Yun Zhu, Shibo Jiang, Lu Lu   +15 more
semanticscholar   +1 more source

In silico evaluation of the interaction between ACE2 and SARS-CoV-2 Spike protein in a hyperglycemic environment

Scientific Reports, 2021
The worse outcome of COVID-19 in people with diabetes mellitus could be related to the non-enzymatic glycation of human ACE2, leading to a more susceptible interaction with virus Spike protein.
Giovanni Sartore, Davide Bassani, Eugenio Ragazzi, Pietro Traldi, Annunziata Lapolla, Stefano Moro   +5 more
doaj   +1 more source

Production and secretion of functional SARS-CoV-2 spike protein in Chlamydomonas reinhardtii

Frontiers in Plant Science, 2022
The spike protein is the major protein on the surface of coronaviruses. It is therefore the prominent target of neutralizing antibodies and consequently the antigen of all currently admitted vaccines against SARS-CoV-2.
Anna Maria Kiefer, Justus Niemeyer, Anna Probst, Gerhard Erkel, Michael Schroda   +4 more
doaj   +1 more source

Targeting the Interaction Between Spike Protein and Nucleocapsid Protein for Suppression and Detection of Human Coronavirus OC43

Frontiers in Immunology, 2022
Human coronavirus OC43 (HCoV-OC43) is the coronavirus most associated with “common colds”, infections of the upper respiratory tract. Previously, we reported that direct interactions of nucleocapsid (N) protein and C-terminal domain of Spike protein ...
Jinsoo Kim, Minyoung Kim, Dongbum Kim, Sangkyu Park, Mijeong Kang, Kyeongbin Baek, Jun-Kyu Choi, Sony Maharjan, Madhav Akauliya, Younghee Lee, Hyung-Joo Kwon, Hyung-Joo Kwon   +11 more
doaj   +1 more source

Persistent circulation of soluble and extracellular vesicle‐linked Spike protein in individuals with postacute sequelae of COVID‐19

Journal of Medical Virology, 2023
SARS‐CoV‐2, the causative agent of COVID‐19 disease, has resulted in the death of millions worldwide since the beginning of the pandemic in December 2019.
V. Craddock, A. Mahajan, L. Spikes, B. Krishnamachary, A. Ram, Ashok Kumar, Ling Chen, P. Chalise, N. Dhillon   +8 more
semanticscholar   +1 more source

A saposin-lipoprotein nanoparticle system for membrane proteins. [PDF]

, 2016
A limiting factor in membrane protein research is the ability to solubilize and stabilize such proteins. Detergents are used most often for solubilizing membrane proteins, but they are associated with protein instability and poor compatibility with ...
Armache, Jean-Paul, Briggs, John AG, Cheng, Yifan, Flayhan, Ali, Frauenfeld, Jens, Garoff, Henrik, Guettou, Fatma, Jegerschöld, Caroline, Löving, Robin, Löw, Christian, Moberg, Per, Nordlund, Pär, Sonnen, Andreas F-P, Zhu, Lin   +13 more
core   +2 more sources

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

Signal Transduction and Targeted Therapy, 2020
In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no specific and effective drugs for treating this disease have been reported until today.
Ke Wang, Wei Chen, Zheng Zhang, Yongqiang Deng, J. Lian, Peng Du, D. Wei, Yang Zhang, Xiu-Xuan Sun, L. Gong, Xu Yang, Lei He, Lei Zhang, Zhiwei Yang, J. Geng, Ruo Chen, Hai Zhang, Bin Wang, Yu-meng Zhu, Gang Nan, Jian-Li Jiang, Ling Li, Jiao Wu, Peng Lin, Wan Huang, Liangzhi Xie, Zhaohui Zheng, Kui Zhang, J. Miao, H. Cui, Min Huang, Jun Zhang, L. Fu, Xiang-Min Yang, Zhongpeng Zhao, Shihui Sun, Hongjing Gu, Zhe Wang, Chun-fu Wang, Ya-cheng Lu, Ying-ying Liu, Qingyi Wang, H. Bian, P. Zhu, Zhi-Nan Chen   +44 more
semanticscholar   +1 more source

The avian coronavirus spike protein

Virus Research, 2014
Avian coronaviruses of the genus Gammacoronavirus are represented by infectious bronchitis virus (IBV), the coronavirus of chicken. IBV causes a highly contagious disease affecting the respiratory tract and, depending on the strain, other tissues including the reproductive and urogenital tract.
I.N. Ambepitiya Wickramasinghe, S.J. van Beurden, E.A.W.S. Weerts, M.H. Verheije   +3 more
openaire   +5 more sources

Human SARS CoV ‐2 spike protein mutations [PDF]

Proteins: Structure, Function, and Bioinformatics, 2020
Abstract The human spike protein sequences from Asia, Africa, Europe, North America, South America, and Oceania were analyzed by comparing with the reference severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) protein sequence from Wuhan‐Hu‐1, China.
openaire   +2 more sources

Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species [PDF]

, 2021
ABSTRACTIn the SARS-CoV-2 coronavirus pandemic of 2019 (COVID-19), it has become evident that the ACE-2 receptor-binding domain (RBD) of the viral spike protein (SP) is the target of neutralizing antibodies that comprise a critical element of protective immunity to the virus.
Melvin E. Klegerman, Jeffrey D. Cirillo, David D. McPherson   +2 more
openaire   +1 more source