Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface [PDF]
, 2020 The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares substantial similarity with SARS-CoV. Here, using a computational model of the spike protein (S-protein) of SARS-CoV-2 interacting with the human ACE2 receptor, we make use
Jeremy C., Smith +3 more
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European review for medical and pharmacological sciences, 2023 COVID-19 patients experience, in 10-20% of the cases, a prolonged long-COVID syndrome, defined as the persistence of symptoms for at least two months after the infection. The underlying biological mechanisms of this syndrome remain poorly understood.
Dhuli, K. +11 more
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Interaction Analyses on SARS-CoV-2 Spike Protein Based on Large-Scale Correlated Fragment Molecular Orbital Calculations [PDF]
, 2020 At the stage of SARS-CoV-2 infection to human cell, the spike protein consisting of three chains, A, B and C, with a total of 3.3 thousand residues plays the key role, and thus its nature have attracted considerable interests. Here, we report interaction
Koji, Okuwaki +6 more
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N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation [PDF]
, 2021 The infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) resulted in a pandemic with huge death toll and economic consequences.
Chandru, Subramani +14 more
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Frontiers in Immunology, 2022 Human coronavirus OC43 (HCoV-OC43) is the coronavirus most associated with “common colds”, infections of the upper respiratory tract. Previously, we reported that direct interactions of nucleocapsid (N) protein and C-terminal domain of Spike protein ...
Jinsoo Kim +11 more
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Biosynthesis and Function of the Coronavirus Spike Protein [PDF]
, 1990 One of the most interesting aspects of Coronavirus replication is their intracellular assembly. Budding is localized in the ER-pre Golgi region (8, 26). Both Coronavirus glycoproteins are synthesized in the RER on membrane bound ribosomes (16). The integral membrane protein (M) accumulates in the perinuclear region and is believed to determine the site
H, Vennema +5 more
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Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis [PDF]
, 2014 Recent evidence suggests that a mutation in the spike protein gene of feline coronavirus (FCoV), which results in an amino acid change from methionine to leucine at position 1058, may be associated with feline infectious peritonitis (FIP).
Tasker, S +21 more
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ACE-2-derived Biomimetic Peptides for the Inhibition of Spike Protein of SARS-CoV-2 [PDF]
, 2020 SARS-CoV-2, a novel coronavirus causing overwhelming death and infection worldwide, has emerged as a pandemic. Compared to its predecessor SARS-CoV, SARS-CoV-2 is more infective for being highly contagious and exhibiting tighter binding with host ...
Satyaranjan, Biswal +4 more
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Anti-Platelet Factor 4 Antibodies Causing VITT do not Cross-React with SARS-CoV-2 Spike Protein [PDF]
, 2021 Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and COVID-19 vaccine Janssen (Ad26.COV2.S), and associated with unusual thrombosis.
Scheer, Christian +25 more
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Frontiers in Immunology, 2021 Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has not been confirmed in altering viral antigenicity resulting in immune escape. To identify crucial
Chengchao Ding +11 more
doaj +1 more source