Results 41 to 50 of about 7,075,307 (355)

Molecular Evolutionary Analyses of the Spike Protein Gene and Spike Protein in the SARS-CoV-2 Omicron Subvariants

Microorganisms, 2023
To better understand the evolution of the SARS-CoV-2 Omicron subvariants, we performed molecular evolutionary analyses of the spike (S) protein gene/S protein using advanced bioinformatics technologies. First, time-scaled phylogenetic analysis estimated that a common ancestor of the Wuhan, Alpha, Beta, Delta variants, and Omicron variants/subvariants ...
Norika Nagasawa, Ryusuke Kimura, Mao Akagawa, Tatsuya Shirai, Mitsuru Sada, Kaori Okayama, Yuka Sato-Fujimoto, Makoto Saito, Mayumi Kondo, Kazuhiko Katayama, Akihide Ryo, Makoto Kuroda, Hirokazu Kimura   +12 more
openaire   +3 more sources

CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells

Signal Transduction and Targeted Therapy, 2020
In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2, no specific and effective drugs for treating this disease have been reported until today.
Ke Wang, Wei Chen, Zheng Zhang, Yongqiang Deng, J. Lian, Peng Du, D. Wei, Yang Zhang, Xiu-Xuan Sun, L. Gong, Xu Yang, Lei He, Lei Zhang, Zhiwei Yang, J. Geng, Ruo Chen, Hai Zhang, Bin Wang, Yu-meng Zhu, Gang Nan, Jian-Li Jiang, Ling Li, Jiao Wu, Peng Lin, Wan Huang, Liangzhi Xie, Zhaohui Zheng, Kui Zhang, J. Miao, H. Cui, Min Huang, Jun Zhang, L. Fu, Xiang-Min Yang, Zhongpeng Zhao, Shihui Sun, Hongjing Gu, Zhe Wang, Chun-fu Wang, Ya-cheng Lu, Ying-ying Liu, Qingyi Wang, H. Bian, P. Zhu, Zhi-Nan Chen   +44 more
semanticscholar   +1 more source

Persistent Circulation of Soluble and Extracellular vesicle-linked Spike Protein in Individuals with Post-Acute Sequelae of COVID-19

Journal of Medical Virology, 2023
SARS‐CoV‐2, the causative agent of COVID‐19 disease, has resulted in the death of millions worldwide since the beginning of the pandemic in December 2019.
V. Craddock, A. Mahajan, L. Spikes, B. Krishnamachary, A. Ram, Ashok Kumar, Ling Chen, P. Chalise, N. Dhillon   +8 more
semanticscholar   +1 more source

501Y.V2 Spike Protein Resists the Antibody in Atomistic Simulations

, 2021
SARS-CoV-2 Spike (S) protein is a major biological target for COVID-19 vaccine design. Unfortunately, recent reports indicated that Spike (S) protein mutations can lead to antibody resistance.
Son Tung, Ngo
core   +1 more source

Presence of viral spike protein and vaccinal spike protein in the blood serum of patients with long-COVID syndrome.

European review for medical and pharmacological sciences, 2023
COVID-19 patients experience, in 10-20% of the cases, a prolonged long-COVID syndrome, defined as the persistence of symptoms for at least two months after the infection. The underlying biological mechanisms of this syndrome remain poorly understood.
Dhuli, K., Medori, M.C., Micheletti, C., Donato, K., Fioretti, F., Calzoni, A., Praderio, A., De Angelis, M.G., Arabia, G., Cristoni, S., Nodari, S., Bertelli, M.   +11 more
openaire   +2 more sources

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies

Frontiers in Immunology, 2021
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has not been confirmed in altering viral antigenicity resulting in immune escape. To identify crucial
Chengchao Ding, Jun He, Xiangyu Zhang, Chengcheng Jiang, Yong Sun, Yuqing Zhang, Qingqing Chen, Hongliang He, Wenting Li, Jiajia Xie, Zhirong Liu, Yong Gao   +11 more
doaj   +1 more source

Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis [PDF]

, 2014
Recent evidence suggests that a mutation in the spike protein gene of feline coronavirus (FCoV), which results in an amino acid change from methionine to leucine at position 1058, may be associated with feline infectious peritonitis (FIP).
Tasker, S, Harley, Ross, Porter, E, Stuart G Siddell, Séverine Tasker, Day, M J, Ross Harley, Porter, Emily, Siddell, S G, Siddell, Stuart G, Emily Porter, Porter, Emily L, Anja Kipar, Christopher R Helps, Helps, C R, Tasker, Séverine, Kipar, A, Day, Michael J, Kipar, Anja, Helps, Christopher R, Michael J Day, Harley, R   +21 more
core   +1 more source

Biosynthesis and Function of the Coronavirus Spike Protein [PDF]

, 1990
One of the most interesting aspects of Coronavirus replication is their intracellular assembly. Budding is localized in the ER-pre Golgi region (8, 26). Both Coronavirus glycoproteins are synthesized in the RER on membrane bound ribosomes (16). The integral membrane protein (M) accumulates in the perinuclear region and is believed to determine the site
H, Vennema, P J, Rottier, L, Heijnen, G J, Godeke, M C, Horzinek, W J, Spaan   +5 more
openaire   +2 more sources

Penta-peptide ATN-161 based neutralization mechanism of SARS-CoV-2 spike protein

Biochemistry and Biophysics Reports, 2021
SARS-CoV-2 has become a big challenge for the scientific community worldwide. SARS-CoV-2 enters into the host cell by the spike protein binding with an ACE2 receptor present on the host cell. Developing safe and effective inhibitor appears an urgent need
Gulam Rabbani, Saeyoung Nate Ahn, Hyunhwa Kwon, Khurshid Ahmad, Inho Choi   +4 more
doaj   +1 more source

Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation

Science, 2020
Structure of the nCoV trimeric spike The World Health Organization has declared the outbreak of a novel coronavirus (2019-nCoV) to be a public health emergency of international concern.
D. Wrapp, Nianshuang Wang, Kizzmekia S. Corbett, J. Goldsmith, C. Hsieh, O. Abiona, B. Graham, J. McLellan   +7 more
semanticscholar   +1 more source