Results 41 to 50 of about 7,152,333 (341)

Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies

Frontiers in Immunology, 2021
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has not been confirmed in altering viral antigenicity resulting in immune escape. To identify crucial
Chengchao Ding, Jun He, Xiangyu Zhang, Chengcheng Jiang, Yong Sun, Yuqing Zhang, Qingqing Chen, Hongliang He, Wenting Li, Jiajia Xie, Zhirong Liu, Yong Gao   +11 more
doaj   +1 more source

Accurate and precise quantification of Cu,Zn-SOD in human red blood cells using species-specific double and triple IDMS [PDF]

, 2016
Acknowledgements This research was undertaken within the EMRP project HLT05. The EMRP was jointly funded by the EMRP participating countries within EURAMET and the European Union.
Feldmann, Jorg, Gleitzmann, Julia, Raab, Andrea, Schulze, Dirk, Swart, Claudia, Waetzig, Hermann   +5 more
core   +1 more source

Penta-peptide ATN-161 based neutralization mechanism of SARS-CoV-2 spike protein

Biochemistry and Biophysics Reports, 2021
SARS-CoV-2 has become a big challenge for the scientific community worldwide. SARS-CoV-2 enters into the host cell by the spike protein binding with an ACE2 receptor present on the host cell. Developing safe and effective inhibitor appears an urgent need
Gulam Rabbani, Saeyoung Nate Ahn, Hyunhwa Kwon, Khurshid Ahmad, Inho Choi   +4 more
doaj   +1 more source

Accurate quantification of selenoproteins in human plasma/serum by isotope dilution ICP-MS : focus on selenoprotein P [PDF]

, 2017
Acknowledgements The research leading to these results was funded by the EMRP Joint Research Project “Metrology for metalloproteins” (HLT-05 2012). The EMRP is jointly funded by the EMRP participating countries within EURAMET and the European Union.Peer ...
Busto, M. Estela del Castillo, Cuello-Nunez, Susana, Deitrich, Christian L., Fisicaro, Paola, Goenaga-Infante, Heidi, Konopka, Anna, Lehmann, Wolf D., Oster, Caroline, Raab, Andrea   +8 more
core   +1 more source

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Science, 2020
Structure of the nCoV trimeric spike The World Health Organization has declared the outbreak of a novel coronavirus (2019-nCoV) to be a public health emergency of international concern.
D. Wrapp, Nianshuang Wang, Kizzmekia S. Corbett, J. Goldsmith, C. Hsieh, O. Abiona, B. Graham, J. McLellan   +7 more
semanticscholar   +1 more source

Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis

Circulation, 2023
Background: Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these ...
L. Yonker, Zoe N Swank, Y. Bartsch, M. Burns, A. Kane, B. Boribong, Jameson P. Davis, M. Loiselle, T. Novak, Y. Senussi, Chi-An Cheng, Eleanor Burgess, A. Edlow, J. Chou, Audrey Dionne, Duraisamy Balaguru, Manuella Lahoud-Rahme, M. Arditi, B. Julg, A. Randolph, G. Alter, A. Fasano, David R. Walt   +22 more
semanticscholar   +1 more source

Structure of SARS-CoV-2 spike protein

Current Opinion in Virology, 2021
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and devastating socio-economic consequences worldwide. The disease has created urgent needs for intervention strategies to control the crisis and meeting these needs requires a deep ...
Jun Zhang, Tianshu Xiao, Yongfei Cai, Bing Chen   +3 more
openaire   +2 more sources

Na+-leak channel, non-selective (NALCN) regulates myometrial excitability and facilitates successful parturition [PDF]

, 2018
Background/Aims: Uterine contractility is controlled by electrical signals generated by myometrial smooth muscle cells. Because aberrant electrical signaling may cause inefficient uterine contractions and poor reproductive outcomes, there is great ...
Amazu, Chinwendu, Bok, Rachael, England, Sarah K., Hurt, K. Joseph, Ma, Xiaofeng, Reinl, Erin L., Wang, Yong, Wu, Wenjie, Zhao, Peinan   +8 more
core   +3 more sources

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays

bioRxiv, 2020
SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity.
K. H. Crawford, Rachel T. Eguia, A. Dingens, Andrea N. Loes, Keara D. Malone, C. Wolf, H. Chu, M. A. Tortorici, D. Veesler, M. Murphy, D. Pettie, N. King, A. Balazs, J. Bloom   +13 more
semanticscholar   +1 more source

Detection of recombinant Spike protein in the blood of individuals vaccinated against SARS‐CoV‐2: Possible molecular mechanisms

PROTEOMICS - Clinical Applications, 2023
The SARS‐CoV‐2 pandemic prompted the development and use of next‐generation vaccines. Among these, mRNA‐based vaccines consist of injectable solutions of mRNA encoding for a recombinant Spike, which is distinguishable from the wild‐type protein due to ...
Carlo Brogna, S. Cristoni, Giuliano Marino, L. Montano, Valentina Viduto, M. Fabrowski, G. Lettieri, M. Piscopo   +7 more
semanticscholar   +1 more source