Results 41 to 50 of about 3,974,865 (310)

Amyloidogenesis of SARS-CoV-2 Spike Protein [PDF]

Journal of the American Chemical Society, 2021
ABSTRACT SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 Spike protein (S-protein).
Sofie Nyström, Per Hammarström
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Crucial Mutations of Spike Protein on SARS-CoV-2 Evolved to Variant Strains Escaping Neutralization of Convalescent Plasmas and RBD-Specific Monoclonal Antibodies

Frontiers in Immunology, 2021
Small number of SARS-CoV-2 epidemic lineages did not efficiently exhibit a neutralization profile, while single amino acid mutation in the spike protein has not been confirmed in altering viral antigenicity resulting in immune escape. To identify crucial
Chengchao Ding, Jun He, Xiangyu Zhang, Chengcheng Jiang, Yong Sun, Yuqing Zhang, Qingqing Chen, Hongliang He, Wenting Li, Jiajia Xie, Zhirong Liu, Yong Gao   +11 more
doaj   +1 more source

Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH-and Cysteine Protease-Independent Fc gamma R Pathway [PDF]

, 2011
Copyright © 2011, American Society for Microbiology. All Rights Reserved.Public health measures successfully contained outbreaks of the severe acute respiratory syndrome coronavirus (SARS-CoV) infection.
Cheung, Chung y, Marc Daëron, Li, PH, Altmeyer, Ralf, Ping H. Li, Leung, Hiu L, Escriou, N, Dutry, Isabelle, Ming S. Yip, Kien, Francois, Cheung, CY, Dutry, I, Li, Ping H, Benoît Callendret, Nal, B, Chung Y. Cheung, Altmeyer, R, Peiris, J S Malik, Ralf Altmeyer, Bruzzone, R, Jaume, Martial, Martial Jaume, Nicolas Escriou, Callendret, B, Isabelle Dutry, Escriou, Nicolas, Beatrice Nal, Kien, F, Francois Kien, Jaume, M, Yip, MS, Bruzzone, Roberto, J. S. Malik Peiris, Yip, Ming S, Daëron, Marc, Roberto Bruzzone, Hiu L. Leung, Leung, HL, Peiris, JSM, Nal, Beatrice, Daeron, M   +40 more
core   +1 more source

Biosynthesis and Function of the Coronavirus Spike Protein [PDF]

, 1990
One of the most interesting aspects of Coronavirus replication is their intracellular assembly. Budding is localized in the ER-pre Golgi region (8, 26). Both Coronavirus glycoproteins are synthesized in the RER on membrane bound ribosomes (16). The integral membrane protein (M) accumulates in the perinuclear region and is believed to determine the site
H, Vennema, P J, Rottier, L, Heijnen, G J, Godeke, M C, Horzinek, W J, Spaan   +5 more
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Penta-peptide ATN-161 based neutralization mechanism of SARS-CoV-2 spike protein

Biochemistry and Biophysics Reports, 2021
SARS-CoV-2 has become a big challenge for the scientific community worldwide. SARS-CoV-2 enters into the host cell by the spike protein binding with an ACE2 receptor present on the host cell. Developing safe and effective inhibitor appears an urgent need
Gulam Rabbani, Saeyoung Nate Ahn, Hyunhwa Kwon, Khurshid Ahmad, Inho Choi   +4 more
doaj   +1 more source

Proposed algorithm integrating anti-SARS-CoV-2 Spike-Protein-RBD antibody monitoring to manage dialysis centers.

, 2021
Proposed algorithm integrating anti-SARS-CoV-2 Spike-Protein-RBD antibody monitoring to manage dialysis centers.
Jean-Philippe Bourdenx (11524599), Philippe Martin-Dupont (11524605), Thomas Bachelet (4164613), Antoine Pommereau (11524611), Charlie Martinez (11524602), Simon Mucha (6437372), Valerie Perier (11524608)   +6 more
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Spike protein of SARS-CoV-2 suppresses gonadotrophin secretion from bovine anterior pituitaries

The Journal of Reproduction and Development, 2022
Coronavirus disease (COVID-19), the ongoing global pandemic, is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent evidence shows that the virus utilizes angiotensin-converting enzyme 2 (ACE2) as a spike protein receptor ...
Dimas Arya ABDILLAH, Onalenna KEREILWE, Raihana Nasrin FERDOUSY, Risa SAITO, Hiroya KADOKAWA   +4 more
doaj   +1 more source

Molecular Evolutionary Analyses of the Spike Protein Gene and Spike Protein in the SARS-CoV-2 Omicron Subvariants

Microorganisms, 2023
To better understand the evolution of the SARS-CoV-2 Omicron subvariants, we performed molecular evolutionary analyses of the spike (S) protein gene/S protein using advanced bioinformatics technologies. First, time-scaled phylogenetic analysis estimated that a common ancestor of the Wuhan, Alpha, Beta, Delta variants, and Omicron variants/subvariants ...
Norika Nagasawa, Ryusuke Kimura, Mao Akagawa, Tatsuya Shirai, Mitsuru Sada, Kaori Okayama, Yuka Sato-Fujimoto, Makoto Saito, Mayumi Kondo, Kazuhiko Katayama, Akihide Ryo, Makoto Kuroda, Hirokazu Kimura   +12 more
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Binding of the SARS-CoV-2 Spike Protein to the Asialoglycoprotein Receptor on Human Primary Hepatocytes and Immortalized Hepatocyte-Like Cells by Confocal Analysis

Hepatic Medicine: Evidence and Research, 2021
Daniel P Collins,1 Clifford J Steer2,3 1CMDG, LLC, Saint Paul, MN, USA; 2Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA; 3Department of Genetics, Cell Biology and Development, University of Minnesota Medical School ...
Collins DP, Steer CJ
doaj  

Presence of viral spike protein and vaccinal spike protein in the blood serum of patients with long-COVID syndrome.

European review for medical and pharmacological sciences, 2023
COVID-19 patients experience, in 10-20% of the cases, a prolonged long-COVID syndrome, defined as the persistence of symptoms for at least two months after the infection. The underlying biological mechanisms of this syndrome remain poorly understood.
Dhuli, K., Medori, M.C., Micheletti, C., Donato, K., Fioretti, F., Calzoni, A., Praderio, A., De Angelis, M.G., Arabia, G., Cristoni, S., Nodari, S., Bertelli, M.   +11 more
openaire   +2 more sources