Binding of the SARS-CoV-2 spike protein to glycans [PDF]
Science Bulletin, 2020 Abstract The pandemic of SARS-CoV-2 has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing oligosaccharides.
Hao, Wei +9 more
openaire +2 more sources
Vertical flow immunoassay based on carbon black nanoparticles for the detection of IgG against SARS-CoV-2 Spike-protein in human serum: proof-of-concept [PDF]
, 2023 Point-of-care tests play an important role in serological diagnostics of infectious diseases and post-vaccination immunity monitoring, including COVID-19. Currently, lateral flow tests dominate in this area and show good analytical performance.
Pavel , Khramtsov +5 more
core +1 more source
Coronavirus Spike Protein and Tropism Changes
, 2016 (Uploaded by Plazi for the Bat Literature Project) Coronaviruses (CoVs) have a remarkable potential to change tropism. This is particularly illustrated over the last 15 years by the emergence of two zoonotic CoVs, the severe acute respiratory syndrome (SARS)- and Middle East respiratory syndrome (MERS)-CoV. Due to their inherent genetic variability, it
Hulswit, R J G +2 more
openaire +4 more sources
VaccinesThe emergence of new SARS-CoV-2 variants continues to cause challenging problems for the effective control of COVID-19. In this study, we tested the hypothesis of whether a strategy of multivalent and sequential heterologous spike protein vaccinations ...
Rong Liu +10 more
doaj +1 more source
In silico Molecular Docking Analysis Targeting SARSCoV-2 Spike Protein and Selected Herbal Constituents [PDF]
, 2020 In modern drug discovery, molecular docking analysis is routinely used to understand and predict the interaction between a drug molecule and a target protein from a microbe.
Shiv Varan Singh +8 more
core +1 more source
Drug Repurposing for Covid-19: Discovery of Potential Small-Molecule Inhibitors of Spike Protein-ACE2 Receptor Interaction Through Virtual Screening and Consensus Scoring [PDF]
, 2020 Objective There is an increased interest in drug repurposing against Covid-19 (SARS-CoV-2) as its spread has significantly outpaced development of effective therapeutics.
Pedro J., Ballester +6 more
core +1 more source
Flowchart of patient receiving BNT162b2-mRNA vaccines and analysed for IgG anti-SARS-CoV-2 Spike-Protein-RBD. [PDF]
, 2021 Flowchart of patient receiving BNT162b2-mRNA vaccines and analysed for IgG anti-SARS-CoV-2 Spike-Protein-RBD.
Jean-Philippe Bourdenx (11524599) +6 more
core +1 more source
Evaluating SARS-CoV-2 Spike Protein Transfection in HEK-293T Cells for VLP Applications
Journal of Experimental Life ScienceThe spike protein in SARS-CoV-2 works mainly to initiate infections, especially for binding to host cells and fusing with cell membranes. Characterizing SARS-CoV-2 spikes protein transfection cells could optimize the production of VLP in HEK-293T cells ...
Ilmiana Nurur Rohmah +6 more
doaj +1 more source
The SARS-CoV-2 spike protein is vulnerable to moderate electric fields
Nature Communications, 2021 The SARS-CoV-2 Spike protein is essential for viral infectivity and binds to the host receptor ACE2. Here, the authors present MD simulations of the Spike protein and its variants of concern and observe that the Spike protein is destabilised by moderate ...
Claudia R. Arbeitman +3 more
doaj +1 more source
Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus [PDF]
, 2000 Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from ...
Escribano, J. M. +13 more
core +1 more source