Results 61 to 70 of about 7,152,333 (341)

Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants

PLoS Pathogens, 2022
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus is continuously evolving, and this poses a major threat to antibody therapies and currently authorized Coronavirus Disease 2019 (COVID-19) vaccines.
A. Mittal, A. Khattri, Vikash Verma
semanticscholar   +1 more source

SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines

Vaccines, 2021
The world is suffering from the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses its spike protein to enter the host cells. Vaccines that introduce the spike protein into
Yuichiro J. Suzuki, Sergiy G. Gychka
doaj   +1 more source

A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes [PDF]

, 2012
Copyright @ 2012, American Society for Microbiology.Human coronaviruses are associated with upper respiratory tract infections that occasionally spread to the lungs and other organs.
A. Vabret, Abt, Arbour, Arbour, B. Nal, Bonavia, Caignard, Caignard, Callendret, Callow, Caux, Chapuis, Collins, de Swart, de Witte, Desforges, Desforges, Engelmayer, Esposito, F. Tangy, Ferlazzo, Gagneur, Geijtenbeek, Glew, H. Law, Hahm, Hamdorf, Herbst, Hoarau, J. Millet, Kramer, Kärber, Law, Legge, M. L. Albert, M. Mesel-Lemoine, MacDonald, Mahanty, Movassagh, Muller, N. Escriou, Nogueira, O'Doherty, Olweus, P.-O. Vidalain, Pacanowski, Piqueras, Rosenzwajg, Sallusto, Servet-Delprat, Servet-Delprat, Servet-Delprat, Sizun, Spearman, Spiegel, Thitithanyanont, Thornberry, V. Lorin, Vabret, Wang, Yang, Yeager   +61 more
core   +3 more sources

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

Science immunology, 2020
The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a ...
L. Premkumar, Bruno Segovia-Chumbez, R. Jadi, David R. Martinez, R. Raut, A. Markmann, Caleb Cornaby, L. Bartelt, S. Weiss, Yara Park, C. Edwards, E. Weimer, E. Scherer, N. Rouphael, S. Edupuganti, D. Weiskopf, Longping V. Tse, Yixuan J. Hou, D. Margolis, A. Sette, M. Collins, J. Schmitz, R. Baric, A. D. de Silva   +23 more
semanticscholar   +1 more source

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?

Molecular Neurobiology, 2022
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells and results in acute symptoms involving especially the lungs known as COVID-19.
T. Theoharides
semanticscholar   +1 more source

ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

Nature Communications, 2022
Whilst the ChAdOx1 nCoV-19 (AZD1222) vaccine has demonstrated efficacy against symptomatic disease, variants of concern (VOCs) with spike protein substitutions have led researchers to explore updating vaccines from ancestral spike protein.
Neeltje van Doremalen, Jonathan E. Schulz, Danielle R. Adney, Taylor A. Saturday, Robert J. Fischer, Claude Kwe Yinda, Nazia Thakur, Joseph Newman, Marta Ulaszewska, Sandra Belij-Rammerstorfer, Greg Saturday, Alexandra J. Spencer, Dalan Bailey, Colin A. Russell, Sarah C. Gilbert, Teresa Lambe, Vincent J. Munster   +16 more
doaj   +1 more source

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

Journal of Biological Chemistry, 2022
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in edema, vascular inflammation, and coagulation, hallmarks of this severe ...
J. Robles, M. Zamora, Elva Adán-Castro, Lourdes Siqueiros-Márquez, G. Martínez de la Escalera, C. Clapp   +5 more
semanticscholar   +1 more source

Spike Protein Fusion Peptide and Feline Coronavirus Virulence [PDF]

Emerging Infectious Diseases, 2012
Coronaviruses are well known for their potential to change their host or tissue tropism, resulting in unpredictable new diseases and changes in pathogenicity; severe acute respiratory syndrome and feline coronaviruses, respectively, are the most recognized examples.
Chang, H.W., Egberink, H.F., Halpin, R., Spiro, D.J., Rottier, P.J.M.   +4 more
openaire   +4 more sources

Neuronal pentraxins mediate synaptic refinement in the developing visual system [PDF]

, 2006
Peer reviewedPublisher ...
Ball, Sherry, Barres, Ben A., Bjartmar, Lisa, Chapman, Barbara, Cho, Richard, Copenhagen, David, Huberman, Andrew D., Liu, Xiaoquin, Malenka, Robert C., Nakamoto, Masaru, Peachey, Neal S., Perin, Mark S., Prezioso, Jennifer, Renteria, Rene C., Stellwagen, David, Stokes, Caleb C., Susman, Michael W., Ullian, Erik M., Worley, Paul, Xu, Weifeng   +19 more
core   +1 more source

Differential coupling of gibberellin responses by Rht-B1c suppressor alleles and Rht-B1b in wheat highlights a unique role for the DELLA N-terminus in dormancy [PDF]

, 2017
During the Green Revolution, substantial increases in wheat (Triticum aestivum) yields were realized, at least in part, through the introduction of the Reduced height (Rht)-B1b and Rht-D1b semi-dwarfing alleles.
Chandler, Peter Michael, Rohde, Antje, Van De Velde, Karel, Van Der Straeten, Dominique   +3 more
core   +1 more source