Results 61 to 70 of about 7,075,307 (355)

BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein

Frontiers in Immunology, 2022
Since first reported in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly acquiring mutations, particularly in the spike protein, that can modulate pathogenicity, transmission and antibody evasion leading to successive waves ...
Mohanraj Manangeeswaran, Derek D. C. Ireland, Seth G. Thacker, Ha-Na Lee, Logan Kelley-Baker, Aaron P. Lewkowicz, Paul W. Rothlauf, Paul W. Rothlauf, Marjorie Cornejo Pontelli, Louis-Marie Bloyet, Michael A. Eckhaus, Mirian I. Mendoza, Sean Whelan, Daniela Verthelyi   +13 more
doaj   +1 more source

Phase 1–2 Trial of a SARS-CoV-2 Recombinant Spike Protein Nanoparticle Vaccine

New England Journal of Medicine, 2020
Background NVX-CoV2373 is a recombinant severe acute respiratory syndrome coronavirus 2 (rSARS-CoV-2) nanoparticle vaccine composed of trimeric full-length SARS-CoV-2 spike glycoproteins and Matrix-M1 adjuvant.
C. Keech, G. Albert, I. Cho, A. Robertson, Patricia Reed, S. Neal, J. Plested, Mingzhu Zhu, S. Cloney-Clark, Haixia Zhou, Gale Smith, N. Patel, M. Frieman, Robert E. Haupt, James Logue, M. McGrath, S. Weston, P. Piedra, Chinar Desai, Kathleen Callahan, Maggie Lewis, Patricia Price-Abbott, N. Formica, V. Shinde, L. Fries, J. Lickliter, P. Griffin, Bethanie E. Wilkinson, G. Glenn   +28 more
semanticscholar   +1 more source

Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species [PDF]

, 2021
ABSTRACT In the SARS-CoV-2 coronavirus pandemic of 2019 (COVID-19), it has become evident that the ACE-2 receptor-binding domain (RBD) of the viral spike protein (SP) is the target of neutralizing antibodies that comprise a critical element of protective immunity to the virus.
Melvin E. Klegerman, Jeffrey D. Cirillo, David D. McPherson   +2 more
openaire   +1 more source

Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System

Biological Procedures Online, 2021
Background The Interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with Angiotensin converting enzyme 2 (ACE2) on the host cells is a crucial step for the viral entry and infection.
Yuning Shang, Feixiang Chen, Shasha Li, Lijuan Song, Yunzhen Gao, Xinhua Yu, Junfeng Zheng   +6 more
doaj   +1 more source

Structural and antigenic variations in the spike protein of emerging SARS-CoV-2 variants

PLoS Pathogens, 2022
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus is continuously evolving, and this poses a major threat to antibody therapies and currently authorized Coronavirus Disease 2019 (COVID-19) vaccines.
A. Mittal, A. Khattri, Vikash Verma
semanticscholar   +1 more source

Strategies for the Management of Spike Protein-Related Pathology

Microorganisms, 2023
In the wake of the COVID-19 crisis, a need has arisen to prevent and treat two related conditions, COVID-19 vaccine injury and long COVID-19, both of which can trace at least part of their aetiology to the spike protein, which can cause harm through several mechanisms.
Matthew T.J. Halma, Cristof Plothe, Paul Marik, Theresa A. Lawrie   +3 more
openaire   +3 more sources

Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain

Nature Communications, 2022
The omicron variant of SARS-CoV-2 has been spreading rapidly across the globe. The virus-surface spike protein plays a critical role in the cell entry and immune evasion of SARS-CoV-2.
G. Ye, Bin Liu, Fangxing Li
semanticscholar   +1 more source

Assembly of Spikes into Coronavirus Particles Is Mediated by the Carboxy-Terminal Domain of the Spike Protein

Journal of Virology, 2000
ABSTRACT The type I glycoprotein S of coronavirus, trimers of which constitute the typical viral spikes, is assembled into virions through noncovalent interactions with the M protein. Here we demonstrate that incorporation is mediated by the short carboxy-terminal segment comprising the transmembrane and endodomain.
Godeke, G J, de Haan, C A, Rossen, J W, Vennema, H, Rottier, P J   +4 more
openaire   +5 more sources

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

Science immunology, 2020
The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in late 2019 is responsible for a ...
L. Premkumar, Bruno Segovia-Chumbez, R. Jadi, David R. Martinez, R. Raut, A. Markmann, Caleb Cornaby, L. Bartelt, S. Weiss, Yara Park, C. Edwards, E. Weimer, E. Scherer, N. Rouphael, S. Edupuganti, D. Weiskopf, Longping V. Tse, Yixuan J. Hou, D. Margolis, A. Sette, M. Collins, J. Schmitz, R. Baric, A. D. de Silva   +23 more
semanticscholar   +1 more source

Could SARS-CoV-2 Spike Protein Be Responsible for Long-COVID Syndrome?

Molecular Neurobiology, 2022
SARS-CoV-2 infects cells via its spike protein binding to its surface receptor on target cells and results in acute symptoms involving especially the lungs known as COVID-19.
T. Theoharides
semanticscholar   +1 more source