Results 81 to 90 of about 7,075,307 (355)

Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface

, 2020
The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares substantial similarity with SARS-CoV. Here, using a computational model of the spike protein (S-protein) of SARS-CoV-2 interacting with the human ACE2 receptor, we make use
Jeremy C., Smith, Micholas, Smith, Jeremy C. Smith (8467509), Micholas Smith (8464173)   +3 more
core   +1 more source

Coronavirus Spike Protein and Tropism Changes

, 2016
(Uploaded by Plazi for the Bat Literature Project) Coronaviruses (CoVs) have a remarkable potential to change tropism. This is particularly illustrated over the last 15 years by the emergence of two zoonotic CoVs, the severe acute respiratory syndrome (SARS)- and Middle East respiratory syndrome (MERS)-CoV. Due to their inherent genetic variability, it
Hulswit, R J G, de Haan, C A M, Bosch, B-J   +2 more
openaire   +4 more sources

Multivalent and Sequential Heterologous Spike Protein Vaccinations Effectively Induce Protective Humoral Immunity against SARS-CoV-2 Variants

Vaccines
The emergence of new SARS-CoV-2 variants continues to cause challenging problems for the effective control of COVID-19. In this study, we tested the hypothesis of whether a strategy of multivalent and sequential heterologous spike protein vaccinations ...
Rong Liu, Janhavi P. Natekar, Ki-Hye Kim, Heather Pathak, Noopur Bhatnagar, Jannatul Ruhan Raha, Bo Ryoung Park, Anchala Guglani, Chong Hyun Shin, Mukesh Kumar, Sang-Moo Kang   +10 more
doaj   +1 more source

Interaction Analyses on SARS-CoV-2 Spike Protein Based on Large-Scale Correlated Fragment Molecular Orbital Calculations

, 2020
At the stage of SARS-CoV-2 infection to human cell, the spike protein consisting of three chains, A, B and C, with a total of 3.3 thousand residues plays the key role, and thus its nature have attracted considerable interests. Here, we report interaction
Koji, Okuwaki, Yuji, Mochizuki, Ryo, Hatada, Shigenori, Tanaka, Kaori, Fukuzawa, Yuto, Komeiji, Kazuki, Akisawa   +6 more
core   +1 more source

N-acetyl cysteine: A tool to perturb SARS-CoV-2 spike protein conformation

, 2021
The infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) resulted in a pandemic with huge death toll and economic consequences.
Chandru, Subramani, Varun, Dewaker, Umashankar, Velusamy, Amit, Mandal, Utsab, Debnath, Parthasarathi, Bhattacharyya, Amrita, Mitra, Yenamandra S., Prabhakar, Sudhanshu, Vrati, Kiran, Krishnan, Padmakar, Wagh, Shubhra, Agarwal, Raghu, Tadala, Aastha, Baliyan, Anura V, Kurpad   +14 more
core   +1 more source

Integrative structural studies of the SARS-CoV-2 spike protein during the fusion process (2022)

Current Research in Structural Biology, 2022
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic and catastrophic, worldwide health and economic impacts. The spike protein on the viral surface is responsible for viral entry into the host cell. The binding of spike protein to the host cell
Jacob C. Miner, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Karissa Y. Sanbonmatsu, Chang-Shung Tung   +5 more
doaj   +1 more source

An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies

Cell, 2021
Antibodies against the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein prevent SARS-CoV-2 infection. However, the effects of antibodies against other spike protein domains are largely unknown.
Yafei Liu, W. T. Soh, J. Kishikawa, M. Hirose, E. Nakayama, Songling Li, Miwa Sasai, Tatsuya Suzuki, Asa Tada, Akemi Arakawa, S. Matsuoka, Kanako Akamatsu, M. Matsuda, C. Ono, Shiho Torii, K. Kishida, Hui Jin, W. Nakai, N. Arase, A. Nakagawa, Maki Matsumoto, Y. Nakazaki, Y. Shindo, M. Kohyama, K. Tomii, K. Ohmura, S. Ohshima, T. Okamoto, Masahiro Yamamoto, H. Nakagami, Y. Matsuura, A. Nakagawa, Takayuki Kato, M. Okada, D. Standley, T. Shioda, H. Arase   +36 more
semanticscholar   +1 more source

ACE-2-derived Biomimetic Peptides for the Inhibition of Spike Protein of SARS-CoV-2

, 2020
SARS-CoV-2, a novel coronavirus causing overwhelming death and infection worldwide, has emerged as a pandemic. Compared to its predecessor SARS-CoV, SARS-CoV-2 is more infective for being highly contagious and exhibiting tighter binding with host ...
Satyaranjan, Biswal, Saroj Kumar, Panda, Abhik Kumar, Ray, Parth Sarthi Sen, Gupta, Malay Kumar, Rana   +4 more
core   +1 more source

Anti-Platelet Factor 4 Antibodies Causing VITT do not Cross-React with SARS-CoV-2 Spike Protein

, 2021
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe adverse effect of ChAdOx1 nCoV-19 COVID-19 vaccine (Vaxzevria) and COVID-19 vaccine Janssen (Ad26.COV2.S), and associated with unusual thrombosis.
Scheer, Christian, Greinacher, Andreas, Hellmuth, Johannes Christian, Duerschmied, Daniel, Keppler, Oliver, Floeel, Agnes, Napp, Matthias, Wesche, Jan, Lother, Achim, Mueller, Karin Anne Lydia, Reiche, Sven, Gawaz, Meinrad, Palankar, Raghavendra, Thiele, Thomas, Muenchhoff, Maximilian, Mayerle, Julia, Vogelgesang, Antje, Hahnenkamp, Klaus, Selleng, Kathleen, Warkentin, Theodore E., Lucchese, Guglielmo, Lovreglio, Piero, Aebischer, Andrea, Stufano, Angela, Marschalek, Rolf, Rieg, Siegbert   +25 more
core   +1 more source

Evaluating SARS-CoV-2 Spike Protein Transfection in HEK-293T Cells for VLP Applications

Journal of Experimental Life Science
The spike protein in SARS-CoV-2 works mainly to initiate infections, especially for binding to host cells and fusing with cell membranes. Characterizing SARS-CoV-2 spikes protein transfection cells could optimize the production of VLP in HEK-293T cells ...
Ilmiana Nurur Rohmah, Kavana Hafil Kusuma, Yuyun Ika Christina, Dinia Rizqi Dwijayanti, Dewi Mustikaningtyas, Nashi Widodo, Muhammad Sasmito Djati   +6 more
doaj   +1 more source