Results 81 to 90 of about 3,974,865 (310)

Binding of the SARS-CoV-2 spike protein to glycans [PDF]

Science Bulletin, 2020
Abstract The pandemic of SARS-CoV-2 has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing oligosaccharides.
Hao, Wei, Ma, Bo, Li, Ziheng, Wang, Xiaoyu, Gao, Xiaopan, Li, Yaohao, Qin, Bo, Shang, Shiying, Cui, Sheng, Tan, Zhongping   +9 more
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity [PDF]

Nature Communications, 2020
Abstract SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (S G614 ) with the original (S D614 ). We report here pseudoviruses carrying S
Zhang, Lizhou, Jackson, Cody B., Mou, Huihui, Ojha, Amrita, Peng, Haiyong, Quinlan, Brian D., Rangarajan, Erumbi S., Pan, Andi, Vanderheiden, Abigail, Suthar, Mehul S., Li, Wenhui, Izard, Tina, Rader, Christoph, Farzan, Michael, Choe, Hyeryun   +14 more
openaire   +3 more sources

Existence and stability analysis of spiky solutions for the Gierer-Meinhardt system with large reaction rates [PDF]

, 2009
We study the Gierer-Meinhardt system in one dimension in the limit of large reaction rates. First we construct three types of solutions: (i) an interior spike; (ii) a boundary spike and (iii) two boundary spikes.
Winter, M, Juncheng Wei, Matthias Winter, Theodore Kolokolnikov, Kolokolnikov, T, Wei, J   +5 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

A. Risk factors associated with the absence of seroconversion Spike-Protein-RBD IgG anti-SARS-CoV-2.

, 2021
B. Risk factors associated with a low Spike-Protein-RBD IgG anti-SARS-CoV-2 (IgG 7000AU/mL, Last quartile vs other three quartiles).
Jean-Philippe Bourdenx (11524599), Philippe Martin-Dupont (11524605), Thomas Bachelet (4164613), Antoine Pommereau (11524611), Charlie Martinez (11524602), Simon Mucha (6437372), Valerie Perier (11524608)   +6 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source