Results 71 to 80 of about 294,785 (311)

Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans [PDF]

, 2022
Infection of host cells by SARS-CoV-2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1-RBD to undergo a conformational ...
Timothy R., Rudd, Vito, Ferro, Antonella, Bisio, Edwin A., Yates, Michela, Parafioriti, Courtney J., Mycroft-West, Marco, Guerrini, Maurice, Petitou, Stefano, Elli, Minghong, Ni, David G., Fernig, Neha S., Gandhi, Mark A., Skidmore, Jeremy E., Turnbull, Marcelo A., Lima   +14 more
core   +1 more source

Corrigendum: Evaluating SARS-CoV-2 Spike Protein Transfection in HEK-293T Cells for VLP Applications

Journal of Experimental Life Science
The spike protein of SARS-CoV-2 is crucial for initiating infections by binding to host cells and mediating membrane fusion. In this study, HEK-293T cells were transfected with plasmids encoding three structural proteins of SARS-CoV-2, i.e., Spike ...
Ilmiana Nurur Rohmah, Marlita Marlita, Kavana Hafil Kusuma, Yuyun Ika Christina, Dinia Rizqi Dwijayanti, Dewi Mustikaningtyas, Nashi Widodo, M. Sasmito Djati   +7 more
doaj   +1 more source

Drugs repurposing against SARS-CoV2 and the new variant B.1.1.7 (alpha strain) targeting the spike protein: molecular docking and simulation studies

Heliyon, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is responsible for the global COVID-19 pandemic and millions of deaths worldwide. In December 2020, a new alpha strain of SARS-CoV2 was identified in the United Kingdom.
Monu Pande, Debanjan Kundu, Ragini Srivastava   +2 more
doaj   +1 more source

Integrative structural studies of the SARS-CoV-2 spike protein during the fusion process (2022)

Current Research in Structural Biology, 2022
SARS-CoV-2 is the virus responsible for the COVID-19 pandemic and catastrophic, worldwide health and economic impacts. The spike protein on the viral surface is responsible for viral entry into the host cell. The binding of spike protein to the host cell
Jacob C. Miner, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Karissa Y. Sanbonmatsu, Chang-Shung Tung   +5 more
doaj   +1 more source

The Comparison of SARS-CoV-2, SARS-CoV, and MERS-CoV Genome and Spike Protein Variations

Jurnal Riset Biologi dan Aplikasinya, 2021
SARS-CoV-2 is a virus that has caused COVID-19 pandemic. This virus is a new variant of the SARS-CoV virus and also closely related to MERS-CoV, which caused similar acute respiratory infections. All these viruses recognize target cells by binding to the
Choirun Nita Fikriani, I Kade Karisma Gita Ardana, Dwi Listyorini   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transition Structures Between Unbound and Bound SARS-CoV-2 Spike Protein to Human ACE2: Potential Targets for Drug Design [PDF]

, 2020
The recent outbreak of COVID-19 caused by SARS-CoV-2 led to a race in finding a cure. Different drug targets were recognized, but in most cases the main target has been identified in the virus spike protein because it is crucial for the virus to gain ...
Nicola, Zanna
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Coronavirus Spike Proteins in Viral Entry and Pathogenesis

Virology, 2001
u t p r r b e m Coronaviruses comprise a large and diverse family of enveloped, positive-stranded RNA viruses. The Coronaviridae exhibit broad host range, infecting many mammalian and avian species and causing upper respiratory, gastrointestinal, hepatic, and central nervous system diseases.
Gallagher, Thomas M., Buchmeier, Michael J.   +1 more
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source