Results 71 to 80 of about 7,075,307 (355)

Protein Footprinting, Conformational Dynamics and Interface-Adjacent Neutralization ‘Hotspots’ in the SARS-CoV-2 Spike Protein Receptor Binding Domain / Human ACE2 Interaction

, 2020
This study provides an HDX-MS based analysis of the interaction between the SARS-CoV-2 spike protein and the human Angiotensin Converting Enzyme 2. - The data agree exactly with the X-ray co-crystal structure of this complex, but provide additional ...
Dominic, Narang, Derek, Wilson, Matthew, Balmer, D. Andrew, James   +3 more
core   +1 more source

The inhibitory effect of a Corona virus spike protein fragment with ACE2 [PDF]

Biophysical Journal, 2020
ABSTRACT In this paper, we investigate the molecular assembly processes of a Coronavirus Spike protein fragment, the hexapeptide YKYRYL on the ACE2 receptor and its inhibitory effect on the aggregation and activation of the CoV-2 spike receptor protein at the same receptor protein.
Peter, Emanuel K., Schug, Alexander
openaire   +3 more sources

ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

Nature Communications, 2022
Whilst the ChAdOx1 nCoV-19 (AZD1222) vaccine has demonstrated efficacy against symptomatic disease, variants of concern (VOCs) with spike protein substitutions have led researchers to explore updating vaccines from ancestral spike protein.
Neeltje van Doremalen, Jonathan E. Schulz, Danielle R. Adney, Taylor A. Saturday, Robert J. Fischer, Claude Kwe Yinda, Nazia Thakur, Joseph Newman, Marta Ulaszewska, Sandra Belij-Rammerstorfer, Greg Saturday, Alexandra J. Spencer, Dalan Bailey, Colin A. Russell, Sarah C. Gilbert, Teresa Lambe, Vincent J. Munster   +16 more
doaj   +1 more source

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Nature, 2020
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is initiated by virus binding to the ACE2 cell-surface receptors 1 – 4 , followed by fusion of the virus and cell membranes to release the virus genome into the cell.
D. Benton, A. Wrobel, P. Xu, C. Roustan, S. Martin, P. Rosenthal, J. Skehel, S. Gamblin   +7 more
semanticscholar   +1 more source

The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling

Journal of Biological Chemistry, 2022
Vascular endothelial cells (ECs) form a critical interface between blood and tissues that maintains whole-body homeostasis. In COVID-19, disruption of the EC barrier results in edema, vascular inflammation, and coagulation, hallmarks of this severe ...
J. Robles, M. Zamora, Elva Adán-Castro, Lourdes Siqueiros-Márquez, G. Martínez de la Escalera, C. Clapp   +5 more
semanticscholar   +1 more source

HUMAN SARS CoV-2 SPIKE PROTEIN MUTATIONS

, 2020
The human SARS-CoV-2 spike protein sequences from Asia, Africa, Europe, North America, South America and Oceania were analyzed by comparing with the reference SARS-CoV-2 protein sequence from Wuhan-Hu-1, China.
Lalitha, Guruprasad
core   +1 more source

Structural impact on SARS-CoV-2 spike protein by D614G substitution

Science, 2021
How an early variant got ahead Throughout the COVID-19 pandemic, epidemiologists have monitored the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with particular focus on the spike protein.
Jun Zhang, Yongfei Cai, T. Xiao, Jianming Lu, Hanqin Peng, Sarah M. Sterling, R. M. Walsh, Sophia Rits-Volloch, Haisun Zhu, Alec Woosley, Wei Yang, P. Śliż, Bing Chen   +12 more
semanticscholar   +1 more source

Myxobacterial Depsipeptide Chondramides Interrupt SARS-CoV-2 Entry by Targeting Its Broad, Cell Tropic Spike Protein: Antagonistic Prospects for Anti-COVID-19 Drug Discovery

, 2021
The severity of the COVID-19 pandemic necessitated the search for drugs against the causative viral agent, SARS-CoV-2. Among the promising targets is the viral surface of SARS-CoV-2 adorned by spike proteins appearing as crown-like structures known for ...
Joe Anthony, Manzano, Von Novi, de Leon, Delfin Yñigo H., Pilapil, Omar, Villalobos, Mark Tristan J., Quimque, Kin Israel, Notarte, John Jeric P. San, Jose, Allan Patrick, Macabeo, Rey Arturo T., Fernandez   +8 more
core   +1 more source

Binding of the SARS-CoV-2 spike protein to glycans [PDF]

Science Bulletin, 2020
Abstract The pandemic of SARS-CoV-2 has caused a high number of deaths in the world. To combat it, it is necessary to develop a better understanding of how the virus infects host cells. Infection normally starts with the attachment of the virus to cell-surface glycans like heparan sulfate (HS) and sialic acid-containing oligosaccharides.
Hao, Wei, Ma, Bo, Li, Ziheng, Wang, Xiaoyu, Gao, Xiaopan, Li, Yaohao, Qin, Bo, Shang, Shiying, Cui, Sheng, Tan, Zhongping   +9 more
openaire   +2 more sources

Transmission, infectivity, and antibody neutralization of an emerging SARS-CoV-2 variant in California carrying a L452R spike protein mutation

medRxiv, 2021
We identified a novel SARS-CoV-2 variant by viral whole-genome sequencing of 2,172 remnant nasal/nasopharyngeal swab samples from 44 counties in California. Named B.1.427/B.1.429 or 20C/L452R, the variant emerged around May 2020 and increased from 0% to >
Xianding Deng, M. Garcia-Knight, M. Khalid, V. Servellita, Candace Wang, M. Morris, A. Sotomayor-González, Dustin R. Glasner, Kevin R. Reyes, A. Gliwa, N. P. Reddy, Claudia Sanchez San Martin, S. Federman, Jing Cheng, Joanna Balcerek, Jordan Taylor, J. Streithorst, Steve Miller, G. R. Kumar, B. Sreekumar, Pei-Yi Chen, U. Schulze-Gahmen, T. Taha, J. Hayashi, C. Simoneau, Sarah McMahon, Peter V. Lidsky, Yinghong Xiao, P. Hemarajata, N. Green, A. Espinosa, Chantha Kath, M. Haw, J. Bell, J. Hacker, C. Hanson, D. Wadford, C. Anaya, D. Ferguson, L. Lareau, Phillip A. Frankino, H. Shivram, S. Wyman, M. Ott, R. Andino, C. Chiu   +45 more
semanticscholar   +1 more source