Results 91 to 100 of about 3,974,865 (310)

Coronavirus Spike Proteins in Viral Entry and Pathogenesis

open access: yesVirology, 2001
u t p r r b e m Coronaviruses comprise a large and diverse family of enveloped, positive-stranded RNA viruses. The Coronaviridae exhibit broad host range, infecting many mammalian and avian species and causing upper respiratory, gastrointestinal, hepatic, and central nervous system diseases.
Gallagher, Thomas M.   +1 more
openaire   +2 more sources

Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus

open access: yes, 2000
Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from ...
Escribano, J. M.   +13 more
core   +1 more source

Ultrafast visual detection of Streptococcus suis via HtpsC‐targeted LAMP–CRISPR–Cas12a coupled with lateral flow immunochromatography

open access: yesFEBS Open Bio, EarlyView.
A rapid visual test combines DNA amplification, CRISPR–based target verification, and a lateral flow strip to detect Streptococcus suis. The assay gives results in about 45 min, reduces false‐positive interpretation, and does not require fluorescence equipment.
Liu‐xin Li   +7 more
wiley   +1 more source

On the stationary Cahn-Hilliard equation: Interior spike solutions [PDF]

open access: yes, 1998
We study solutions of the stationary Cahn-Hilliard equation in a bounded smooth domain which have a spike in the interior. We show that a large class of interior points (the "nondegenerate peak" points) have the following property: there exist such ...
Winter, M, Wei, J
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

open access: yesFEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli   +2 more
wiley   +1 more source

SARS-CoV2 spike protein-derived epitope peptide pools.

open access: yes, 2022
SARS-CoV2 spike protein-derived epitope peptide pools.
Ralph Götz (7172579)   +5 more
core   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Characterisation of the spike protein des SARS CoV

open access: yes, 2011
Charakterisierung des Spike Proteins des Schweren Akutenatemnotsyndrom Coronavirus.Characterisation of the spike protein des SARS ...
Kursawe, Jens
core   +1 more source

SARs-Cov-2 spike protein and ACE2

open access: yes, 2022
Model built as part of a collaborative molecular simulation SARS-COv-2 project investigating the interactions between the SARS-CoV-2 spike protein and ACE2 protein, each component being embedded in its lipid bilayer.
Laurent Chaloin (12269174)   +2 more
core   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay   +15 more
wiley   +1 more source

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