Results 91 to 100 of about 7,075,307 (355)

The SARS-CoV-2 spike protein is vulnerable to moderate electric fields

Nature Communications, 2021
The SARS-CoV-2 Spike protein is essential for viral infectivity and binds to the host receptor ACE2. Here, the authors present MD simulations of the Spike protein and its variants of concern and observe that the Spike protein is destabilised by moderate ...
Claudia R. Arbeitman, Pablo Rojas, Pedro Ojeda-May, Martin E. Garcia   +3 more
doaj   +1 more source

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

bioRxiv, 2020
Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against SARS-CoV-2.
Y. Weisblum, F. Schmidt, Fengwen Zhang, Justin DaSilva, D. Poston, Julio C. C. Lorenzi, Frauke Muecksch, Magda Rutkowska, Hans-Heinrich Hoffmann, E. Michailidis, C. Gaebler, Marianna Agudelo, A. Cho, Zijun Wang, A. Gazumyan, M. Cipolla, Larry L. Luchsinger, C. Hillyer, M. Caskey, D. Robbiani, C. Rice, M. Nussenzweig, T. Hatziioannou, P. Bieniasz   +23 more
semanticscholar   +1 more source

Drugs repurposing against SARS-CoV2 and the new variant B.1.1.7 (alpha strain) targeting the spike protein: molecular docking and simulation studies

Heliyon, 2021
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is responsible for the global COVID-19 pandemic and millions of deaths worldwide. In December 2020, a new alpha strain of SARS-CoV2 was identified in the United Kingdom.
Monu Pande, Debanjan Kundu, Ragini Srivastava   +2 more
doaj   +1 more source

A therapeutic neutralizing antibody targeting receptor binding domain of SARS-CoV-2 spike protein

Nature Communications, 2021
Vaccines and therapeutics are urgently needed for the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we screen human monoclonal antibodies (mAb) targeting the receptor binding domain (RBD) of the viral spike ...
Cheolmin Kim, Dong-Kyun Ryu, Jihun Lee, Young-Il Kim, Ji-Min Seo, Y. Kim, J. Jeong, Minsoo Kim, Jong-In Kim, P. Kim, J. Bae, E. Shim, M. Lee, Man Su Kim, H. Noh, Geun-Soo Park, J. Park, Dain Son, Yongjin An, Jeong No Lee, K. Kwon, Joo-Yeon Lee, Hansaem Lee, Jeong-Sun Yang, Kyung-Chang Kim, S. S. Kim, Hye-Min Woo, Jun-Won Kim, Man-Seong Park, Kwang-Min Yu, Se-Mi Kim, Eun-Ha Kim, Su-Jin Park, S. Jeong, C. Yu, Y. Song, S. Gu, H. Oh, Bon-Sang Koo, J. Hong, C. Ryu, W. Park, M. Oh, Y. Choi, Soo-Young Lee   +44 more
semanticscholar   +1 more source

Sea Urchin Pigments as Potential Therapeutic Agents Against the Spike Protein of SARS-CoV-2 Based on in Silico Analysis

, 2020
Several studies have been published regarding the interaction between the spike protein of the novel coronavirus SARS-CoV-2 and ACE2 receptor in the host cells.
Jimena Pía, Fernandez, Ayelén, Gázquez, Mercedes, Vera-Piombo, Elena Susana, Barbieri, Florencia, Chaar, Marisa, Avaro, Agustín, Gittardi, Lucas, Sepulveda, Tamara, Rubilar, Erina Noé, Seiler   +9 more
core   +1 more source

Corrigendum: Evaluating SARS-CoV-2 Spike Protein Transfection in HEK-293T Cells for VLP Applications

Journal of Experimental Life Science
The spike protein of SARS-CoV-2 is crucial for initiating infections by binding to host cells and mediating membrane fusion. In this study, HEK-293T cells were transfected with plasmids encoding three structural proteins of SARS-CoV-2, i.e., Spike ...
Ilmiana Nurur Rohmah, Marlita Marlita, Kavana Hafil Kusuma, Yuyun Ika Christina, Dinia Rizqi Dwijayanti, Dewi Mustikaningtyas, Nashi Widodo, M. Sasmito Djati   +7 more
doaj   +1 more source

The Comparison of SARS-CoV-2, SARS-CoV, and MERS-CoV Genome and Spike Protein Variations

Jurnal Riset Biologi dan Aplikasinya, 2021
SARS-CoV-2 is a virus that has caused COVID-19 pandemic. This virus is a new variant of the SARS-CoV virus and also closely related to MERS-CoV, which caused similar acute respiratory infections. All these viruses recognize target cells by binding to the
Choirun Nita Fikriani, I Kade Karisma Gita Ardana, Dwi Listyorini   +2 more
doaj   +1 more source

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Cell, 2021
Most human monoclonal antibodies (mAbs) neutralizing SARS-CoV-2 recognize the spike (S) protein receptor-binding domain and block virus interactions with the cellular receptor angiotensin-converting enzyme 2.
Naveenchandra Suryadevara, S. Shrihari, P. Gilchuk, L. VanBlargan, E. Binshtein, Seth J. Zost, Rachel S. Nargi, Rachel E. Sutton, Emma S. Winkler, E. Chen, Mallorie E. Fouch, E. Davidson, B. Doranz, Rita E. Chen, Pei-Yong Shi, R. Carnahan, Larissa B. Thackray, M. Diamond, J. Crowe   +18 more
semanticscholar   +1 more source

Proposed algorithm integrating anti-SARS-CoV-2 Spike-Protein-RBD antibody monitoring to manage dialysis centers.

, 2021
Proposed algorithm integrating anti-SARS-CoV-2 Spike-Protein-RBD antibody monitoring to manage dialysis centers.
Jean-Philippe Bourdenx (11524599), Philippe Martin-Dupont (11524605), Thomas Bachelet (4164613), Antoine Pommereau (11524611), Charlie Martinez (11524602), Simon Mucha (6437372), Valerie Perier (11524608)   +6 more
core   +1 more source

A glycan gate controls opening of the SARS-CoV-2 spike protein

Nature Chemistry, 2021
SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded ‘down’ to an exposed ‘up’ state to bind the human angiotensin-converting enzyme 2 receptor and infect cells ...
Terra Sztain, Surl-Hee Ahn, Anthony T. Bogetti, L. Casalino, J. Goldsmith, Evan Seitz, R. S. McCool, Fiona L. Kearns, F. Acosta-Reyes, Suvrajit Maji, G. Mashayekhi, J. McCammon, A. Ourmazd, J. Frank, J. McLellan, L. Chong, Rommie E. Amaro   +16 more
semanticscholar   +1 more source