Results 111 to 120 of about 7,075,307 (355)

SARS-CoV-2 Spike protein alters microglial purinergic signaling

Frontiers in Immunology, 2023
Despite long-term sequelae of COVID-19 are emerging as a substantial public health concern, the mechanism underlying these processes still unclear. Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of ...
Vinícius Santos Alves, Stephanie Alexia Cristina Silva Santos, Raíssa Leite-Aguiar, Elaine Paiva-Pereira, Renata Rodrigues dos Reis, Mariana L. Calazans, Gabriel Gripp Fernandes, Leticia Silva Antônio, Emanuelle V. de Lima, Eleonora Kurtenbach, Jerson Lima Silva, Fabricia Lima Fontes-Dantas, Fabricia Lima Fontes-Dantas, Giselle Fazzioni Passos, Cláudia Pinto Figueiredo, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +16 more
doaj   +1 more source

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

Nature Communications, 2021
The coronavirus spike glycoprotein, located on the virion surface, is the key mediator of cell entry and the focus for development of protective antibodies and vaccines.
Chunyan Wang, R. van Haperen, J. Gutiérrez-Álvarez, Wentao Li, Nisreen M. A. Okba, I. Albulescu, Ivy Widjaja, Brenda van Dieren, R. Fernández-Delgado, I. Sola, Daniel L. Hurdiss, O. Daramola, F. Grosveld, F. V. van Kuppeveld, B. Haagmans, L. Enjuanes, D. Drabek, B. Bosch   +17 more
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

In vitro Selection of an Aptamer Targeting SARS-CoV-2 Spike Protein with Nanopore Sequence Identification Reveals Discrimination Between the Authentic Strain and Omicron

, 2022
DNA aptamers are oligonucleotides specifically bound to target molecules that can serve as antibodies of nucleic acid nature. For diagnosing the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), methods using antibodies specific ...
Denis, Kolesov, Lyudmila, Nikiforova, Timofei, Zatsepin, Maria, Sinegubova, Fedor, Grabovenko, Maria, Khrenova, Nadezhda, Orlova, Maria, Zvereva, Elena, Zavyalova, Vera, Spiridonova   +9 more
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Computer-Aided Approaches to De Novo Design of drug candidates targeting the SARS-CoV-2 Spike protein bound to angiotensin converting enzyme 2 (ACE2)

, 2021
In this study a computer-aided approach to de novo design of chemical entities with drug-like properties against the SARS-CoV-2 Spike protein bound to ACE2 is presented. A structure-based de novo drug design tool LIGANN was used to produce complementary
Konstantinos, Kalamatianos
core   +1 more source

Coronavirus Spike Proteins in Viral Entry and Pathogenesis

Virology, 2001
u t p r r b e m Coronaviruses comprise a large and diverse family of enveloped, positive-stranded RNA viruses. The Coronaviridae exhibit broad host range, infecting many mammalian and avian species and causing upper respiratory, gastrointestinal, hepatic, and central nervous system diseases.
Gallagher, Thomas M., Buchmeier, Michael J.   +1 more
openaire   +2 more sources

Spike Protein Fusion Peptide and Feline Coronavirus Virulence [PDF]

Emerging Infectious Diseases, 2012
Coronaviruses are well known for their potential to change their host or tissue tropism, resulting in unpredictable new diseases and changes in pathogenicity; severe acute respiratory syndrome and feline coronaviruses, respectively, are the most recognized examples.
Chang, H.W., Egberink, H.F., Halpin, R., Spiro, D.J., Rottier, P.J.M.   +4 more
openaire   +4 more sources

Development of a Colloidal Gold-Based Immunochromatographic Strip for Rapid Detection of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein

Frontiers in Immunology, 2021
The outbreak and worldwide pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a significant impact on global economy and human health. In order to reduce the disease spread, 16 monoclonal antibodies (McAbs) again SARS-
Ge Li, Ge Li, Aiping Wang, Yumei Chen, Yaning Sun, Yongkun Du, Xun Wang, Peiyang Ding, Rui Jia, Yanwei Wang, Gaiping Zhang, Gaiping Zhang   +11 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source