Results 101 to 110 of about 3,974,865 (310)
Drug Repurposing for Covid-19: Discovery of Potential Small-Molecule Inhibitors of Spike Protein-ACE2 Receptor Interaction Through Virtual Screening and Consensus Scoring [PDF]
, 2020 Objective There is an increased interest in drug repurposing against Covid-19 (SARS-CoV-2) as its spread has significantly outpaced development of effective therapeutics.
Pedro J., Ballester +20 more
core +2 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Jian Wang, Mengjiao Li, Ping Kong
wiley +1 more source
The spike tip protein of bacteriophage T4
Contractile injection systems (CISs) – bacteriophage tails, tailocins, and bacterial type VI secretion systems – penetrate the envelope of the target cell by employing a contractile sheath-rigid tube mechanism. The membrane-attacking end of the tube carries a spike-shaped complex that ends with a spike tip.
Yves Mattenberger +7 more
openaire +2 more sources
Patients improve, patterns persist: longitudinal stability of RA joint involvement patterns
Arthritis Care &Research, Accepted Article.Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen +24 more
wiley +1 more source
ELISA binding results to different spike protein variants.
, 2022 ELISA binding results to different spike protein variants.
Kamaljit Bajwa (12769627) +17 more
core +1 more source
Advanced Functional Materials, EarlyView.This review revisits optoelectronic neuromorphic devices that extend from unimodal sensing toward multimodal perception. Five types of stimuli‐to‐output information flow that are classified based on the device roles within the system and applications are summarized and discussed.
Jihyun Shin +6 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou +6 more
wiley +1 more source
Advanced Functional Materials, EarlyView.A geometry‐reconfigured additive manufacturing strategy converts planar printed soft materials into soft compact neural probes with integrated hydrogel electrodes and microfluidic channels. The resulting NeuroMAP platform enables scalable multichannel recording, localized chemical delivery, stable in vivo electrophysiological recording, and reduced ...
Hyunjin Lee +15 more
wiley +1 more source
Assembly of the Sindbis Virus Spike Protein Complex
Virology, 1996 The Sindbis virus glycoproteins E1 and E2 are organized into 80 trimers of heterodimers within the virus envelope. Using pulse-chase protocols and chemical crosslinkers, we have found that E1 and E2 precursor, PE2, rapidly assemble into heterodimers and then into trimers of heterodimers after translocation into the endoplasmic reticulum.
MULVEY, MATTHEW, BROWN, DENNIS T.
openaire +2 more sources
SARS-CoV-2 spike protein induces salivary gland dysfunction and immune infiltration in C57BL/6 mice
Frontiers in ImmunologySalivary gland dysfunction and inflammation are common following SARS-CoV-2 infection. This study aimed to investigate the effects of SARS-CoV-2 spike and envelope proteins on glandular function in healthy C57BL/6 mice through direct intra-glandular ...
Fernanda Aragão Felix +9 more
doaj +1 more source