Results 121 to 130 of about 7,075,307 (355)

Glycosylation and oligomerization of the spike protein of marburg virus

Virology, 1991
The oligosaccharide side chains of the glycoprotein of Marburg virus (MW 170,000) have been analyzed by determining their sensitivity to enzymatic degradation and their reactivity with lectins. It was found that they consist of N- and O-glycans. Studies employing chemical cross-linking showed that the glycoprotein is present as a homotrimer in the ...
Feldmann, H., Will, C., Schikore, M., Slenczka, W., Klenk, H.-D.   +4 more
openaire   +2 more sources

Murine alveolar macrophages rapidly accumulate intranasally administered SARS-CoV-2 Spike protein leading to neutrophil recruitment and damage

eLife
The trimeric SARS-CoV-2 Spike protein mediates viral attachment facilitating cell entry. Most COVID-19 vaccines direct mammalian cells to express the Spike protein or deliver it directly via inoculation to engender a protective immune response.
Chung Park, Il-Young Hwang, Serena Li-Sue Yan, Sinmanus Vimonpatranon, Danlan Wei, Don Van Ryk, Alexandre Girard, Claudia Cicala, James Arthos, John H Kehrl   +9 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Metalloprotease-Dependent S2′-Activation Promotes Cell–Cell Fusion and Syncytiation of SARS-CoV-2

Viruses, 2022
SARS-CoV-2 cell–cell fusion and syncytiation is an emerging pathomechanism in COVID-19, but the precise factors contributing to the process remain ill-defined.
James V. Harte, Samantha L. Wakerlin, Andrew J. Lindsay, Justin V. McCarthy, Caroline Coleman-Vaughan   +4 more
doaj   +1 more source

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

bioRxiv, 2020
Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific antiviral drugs for treatment of the disease, which poses great challenge to ...
Ke Wang, Wei Chen, Yu-sen Zhou, J. Lian, Zheng Zhang, Peng Du, L. Gong, Yang Zhang, H. Cui, J. Geng, Bin Wang, Xiuxuan Sun, Chun-fu Wang, Xu Yang, Peng Lin, Yongqiang Deng, D. Wei, Xiang-Min Yang, Yu-meng Zhu, Kui Zhang, Zhaohui Zheng, J. Miao, Ting Guo, Ying Shi, Jun Zhang, L. Fu, Qingyi Wang, H. Bian, P. Zhu, Zhi-Nan Chen   +29 more
semanticscholar   +1 more source

Rapid Development of SARS-CoV-2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine Candidates

ACS Nano, 2021
The coronavirus disease pandemic of 2019 (COVID-19) caused by the novel SARS-CoV-2 coronavirus resulted in economic losses and threatened human health worldwide. The pandemic highlights an urgent need for a stable, easily produced, and effective vaccine.
Yinfeng Kang, Cong Sun, Zhuan Zhen, R. Yuan, Q. Zheng, Jiang Li, Pingping Zhou, Xin-Chun Chen, Zhe Liu, Xiao Zhang, Xiao-Hui Yu, Xiang-Wei Kong, Qianying Zhu, Qian Zhong, Miao Xu, N. Zhong, Y. Zeng, Guokai Feng, C. Ke, Jin-Cun Zhao, M. Zeng   +20 more
semanticscholar   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Existence and stability analysis of spiky solutions for the Gierer-Meinhardt system with large reaction rates

, 2009
We study the Gierer-Meinhardt system in one dimension in the limit of large reaction rates. First we construct three types of solutions: (i) an interior spike; (ii) a boundary spike and (iii) two boundary spikes.
Winter, M, Juncheng Wei, Matthias Winter, Theodore Kolokolnikov, Kolokolnikov, T, Wei, J   +5 more
core   +1 more source

Phytochemicals as a potential inhibitor of Spike Protein of SARS-CoV-2 Omicron Variant

Jurnal Kedokteran Diponegoro, 2023
Background: More than 50 mutations have been found in Omicron SARS-CoV-2. Most Omicron mutations are located in the spike protein, which plays a pivotal role in virus infection.
Tuti Ratnasari, Faizah Fulyani, Endang Mahati   +2 more
doaj   +1 more source

Neutralising antibody escape of SARS‐CoV‐2 spike protein: Risk assessment for antibody‐based Covid‐19 therapeutics and vaccines

Reviews in Medical Virology, 2021
The Spike protein is the target of both antibody‐based therapeutics (convalescent plasma, polyclonal serum, monoclonal antibodies) and vaccines. Mutations in Spike could affect efficacy of those treatments.
D. Focosi, F. Maggi
semanticscholar   +1 more source