Results 121 to 130 of about 7,152,333 (341)

A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies

Nature Communications, 2021
The coronavirus spike glycoprotein, located on the virion surface, is the key mediator of cell entry and the focus for development of protective antibodies and vaccines.
Chunyan Wang, R. van Haperen, J. Gutiérrez-Álvarez, Wentao Li, Nisreen M. A. Okba, I. Albulescu, Ivy Widjaja, Brenda van Dieren, R. Fernández-Delgado, I. Sola, Daniel L. Hurdiss, O. Daramola, F. Grosveld, F. V. van Kuppeveld, B. Haagmans, L. Enjuanes, D. Drabek, B. Bosch   +17 more
semanticscholar   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Metalloprotease-Dependent S2′-Activation Promotes Cell–Cell Fusion and Syncytiation of SARS-CoV-2

Viruses, 2022
SARS-CoV-2 cell–cell fusion and syncytiation is an emerging pathomechanism in COVID-19, but the precise factors contributing to the process remain ill-defined.
James V. Harte, Samantha L. Wakerlin, Andrew J. Lindsay, Justin V. McCarthy, Caroline Coleman-Vaughan   +4 more
doaj   +1 more source

Linear epitope landscape of the SARS-CoV-2 Spike protein constructed from 1,051 COVID-19 patients

Cell Reports, 2021
To fully decipher the immunogenicity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein, it is essential to assess which part is highly immunogenic in a systematic way.
Yang Li, Ming-liang Ma, Qing Lei, Feng Wang, W. Hong, Dan-yun Lai, Hongyan Hou, Zhaowei Xu, Bo Zhang, Hong Chen, Caizheng Yu, Jun-biao Xue, Yun-xiao Zheng, Xue-ning Wang, He-wei Jiang, Hai-nan Zhang, H. Qi, Shu-juan Guo, Yandi Zhang, Xiaosong Lin, Zongjie Yao, Jiaoxiang Wu, Huiming Sheng, Yanan Zhang, Hongping Wei, Ziyong Sun, Xionglin Fan, S. Tao   +27 more
semanticscholar   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Phytochemicals as a potential inhibitor of Spike Protein of SARS-CoV-2 Omicron Variant

Jurnal Kedokteran Diponegoro, 2023
Background: More than 50 mutations have been found in Omicron SARS-CoV-2. Most Omicron mutations are located in the spike protein, which plays a pivotal role in virus infection.
Tuti Ratnasari, Faizah Fulyani, Endang Mahati   +2 more
doaj   +1 more source

The local translation of KNa in dendritic projections of auditory neurons and the roles of KNa in the transition from hidden to overt hearing loss [PDF]

, 2019
Local and privileged expression of dendritic proteins allows segregation of distinct functions in a single neuron but may represent one of the underlying mechanisms for early and insidious presentation of sensory neuropathy.
Chiamvimonvat, Nipavan, Gratton, Michael Anne, Kang, Mincheol, Lee, Jeong Han, Park, Seojin, Perez-Flores, Maria C, Wang, Wenying, Yamoah, Ebenezer N, Zhang, Xiao-Dong   +8 more
core   +1 more source

SARS-CoV-2 invades host cells via a novel route: CD147-spike protein

bioRxiv, 2020
Currently, COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been widely spread around the world; nevertheless, so far there exist no specific antiviral drugs for treatment of the disease, which poses great challenge to ...
Ke Wang, Wei Chen, Yu-sen Zhou, J. Lian, Zheng Zhang, Peng Du, L. Gong, Yang Zhang, H. Cui, J. Geng, Bin Wang, Xiuxuan Sun, Chun-fu Wang, Xu Yang, Peng Lin, Yongqiang Deng, D. Wei, Xiang-Min Yang, Yu-meng Zhu, Kui Zhang, Zhaohui Zheng, J. Miao, Ting Guo, Ying Shi, Jun Zhang, L. Fu, Qingyi Wang, H. Bian, P. Zhu, Zhi-Nan Chen   +29 more
semanticscholar   +1 more source

Neutralising antibody escape of SARS‐CoV‐2 spike protein: Risk assessment for antibody‐based Covid‐19 therapeutics and vaccines

Reviews in Medical Virology, 2021
The Spike protein is the target of both antibody‐based therapeutics (convalescent plasma, polyclonal serum, monoclonal antibodies) and vaccines. Mutations in Spike could affect efficacy of those treatments.
D. Focosi, F. Maggi
semanticscholar   +1 more source

Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz, Josefine Eck, Joel S. Winston, Kate Baker   +3 more
wiley   +1 more source