Results 141 to 150 of about 7,075,307 (355)

Assembly of the Sindbis Virus Spike Protein Complex

Virology, 1996
The Sindbis virus glycoproteins E1 and E2 are organized into 80 trimers of heterodimers within the virus envelope. Using pulse-chase protocols and chemical crosslinkers, we have found that E1 and E2 precursor, PE2, rapidly assemble into heterodimers and then into trimers of heterodimers after translocation into the endoplasmic reticulum.
MULVEY, MATTHEW, BROWN, DENNIS T.
openaire   +2 more sources

COVID‐19 Vaccination Is Not Associated With the Development of Idiopathic Inflammatory Myositis in US Veterans

Arthritis Care &Research, EarlyView.
Objective Several case reports have proposed a potential association between COVID‐19 vaccination and the subsequent development of idiopathic inflammatory myositis (IIM). This study examined prior COVID‐19 vaccination in US veterans who developed new‐onset IIM compared to those without new‐onset IIM.
Caleb Hernández, Naomi Schlesinger, Jorge Rojas, Jessica A. Walsh, Tawnie J. Braaten, Gary A. Kunkel, Makoto Jones, Brian C Sauer, Julio Facelli, Grant W. Cannon, Dorota Lebiedz‐Odrobina   +10 more
wiley   +1 more source

Oral immunogenicity of the plant derived spike protein from swine-transmissible gastroenteritis coronavirus

, 2000
Transgenic plants represent an inexpensive alternative to classical fermentation systems for production of recombinant subunit vaccines. Transgenic potato plants were created that express the N-terminal domain of the glycoprotein S (N-gS) from ...
Escribano, J. M., Gómez, Nestor, Gómez, Nuria, Castañón, Sonia, Wigdorovitz, Andres, Gil Dones, Félix, Escribano, José, Ordá, R., Wigdorovitz, A., Borca, M. V., Ordá, Ricardo, Gil, Félix, Castañón, S., Borca, Manuel   +13 more
core   +1 more source

Evidence for multiple binding modes in the initial contact between SARS-CoV-2 spike S1 protein and cell surface glycans

, 2022
Infection of host cells by SARS-CoV-2 begins with recognition by the virus S (spike) protein of cell surface heparan sulfate (HS), tethering the virus to the extracellular matrix environment, and causing the subunit S1-RBD to undergo a conformational ...
Timothy R., Rudd, Vito, Ferro, Antonella, Bisio, Edwin A., Yates, Michela, Parafioriti, Courtney J., Mycroft-West, Marco, Guerrini, Maurice, Petitou, Stefano, Elli, Minghong, Ni, David G., Fernig, Neha S., Gandhi, Mark A., Skidmore, Jeremy E., Turnbull, Marcelo A., Lima   +14 more
core   +1 more source

Retractions in Rheumatology: Trends, Causes, and Implications for Research Integrity

Arthritis Care &Research, EarlyView.
Objective We aimed to describe the trends and main reasons for study retraction in rheumatology literature. Methods We reviewed the Retraction Watch database to identify retracted articles in rheumatology. We recorded the main study characteristics, authors’ countries, reasons for retraction, time from publication to retraction, and trends over time ...
Anna Maria Vettori, Michele Iudici
wiley   +1 more source

Sialic Acid Binding Properties of Soluble Coronavirus Spike (S1) Proteins: Differences between Infectious Bronchitis Virus and Transmissible Gastroenteritis Virus

Viruses, 2013
The spike proteins of a number of coronaviruses are able to bind to sialic acids present on the cell surface. The importance of this sialic acid binding ability during infection is, however, quite different. We compared the spike protein of transmissible
Christine Winter, Georg Herrler, Ann-Kathrin Mork, Martina Hesse, Katarina Shahwan   +4 more
doaj   +1 more source

Exploring an Alternative to mRNA Vaccine Cold Chain Storage: MRNA‐Lipid Nanoparticle Stability When Dried in a Polymer Matrix

Advanced Functional Materials, EarlyView.
The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett, Shahad K. Alsaiari, John L. Daristotle, Timothy A. Forster, Alicia Lau, Dhruv Varshney, Rania Afaneh, Andrew R. Hanna, Charles Sloane, David Mankus, Haitao Yu, Jiali Zhai, DongSoo Yun, Lisa H. Tostanoski, Abigail Lytton‐Jean, Dan H. Barouch, Charlotte E. Conn, Robert Langer, Ana Jaklenec, Calum J. Drummond   +19 more
wiley   +1 more source

Neural Coding and Feature Extraction of Time-Varying Signals [PDF]

, 2002
What are the neuronal codes that the brain uses to represent information? This constitutes one of the most fascinating and challenging questions in Neuroscience.
Kreiman, Gabriel Alejandro
core   +1 more source

Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

Nature Communications
The multibasic furin cleavage site at the S1/S2 boundary of the spike protein is a hallmark of SARS-CoV-2 and plays a crucial role in viral infection. However, the mechanism underlying furin activation and its regulation remain poorly understood.
Shengjun Wang, Wei Ran, Lingyu Sun, Qingchi Fan, Yuanqi Zhao, Bowen Wang, Jinghong Yang, Yuqi He, Ying Wu, Yuanyuan Wang, Luoyi Chen, Arpaporn Chuchuay, Yuyu You, Xinhai Zhu, Xiaojuan Wang, Ye Chen, Yanqun Wang, Yao-Qing Chen, Yanqiu Yuan, Jincun Zhao, Yang Mao   +20 more
doaj   +1 more source

Cdc42 improve SARS-CoV-2 spike protein-induced cellular senescence through activating of Wnt/β-Catenin signaling pathway

Frontiers in Cellular and Infection Microbiology
IntroductionSARS-CoV-2 infection drove senescent cells and the senescence-associated phenotypes were reported playing roles in disease progression, which contributes to severe COVID-19 and related sequelae. Cdc42 is involved in the regulation of cellular
Chunmei Nong, Chunmei Nong, Chunmei Nong, Zhenzhen Wu, Chan Yang, Wei Xu, Linyi Luo, Jianping Zhou, Lihan Shen, Yinghua Chen, Yinghua Chen, Yaoqin Yuan, Guodong Hu, Guodong Hu, Guodong Hu   +14 more
doaj   +1 more source