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SARS-CoV-2 Spike Protein Interaction Space
International Journal of Molecular Sciences, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a +sense single-strand RNA virus. The virus has four major surface proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N), respectively. The constitutive proteins present a high grade of symmetry. Identifying a binding site is difficult. The virion is approximately 50–200 nm
Claudiu N. Lungu, Mihai V. Putz
openaire +2 more sources
Spike protein of SARS-CoV-2 suppresses gonadotrophin secretion from bovine anterior pituitaries
The Journal of Reproduction and Development, 2022 Coronavirus disease (COVID-19), the ongoing global pandemic, is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent evidence shows that the virus utilizes angiotensin-converting enzyme 2 (ACE2) as a spike protein receptor ...
Dimas Arya ABDILLAH +4 more
doaj +1 more source
SARS-CoV-2 and the spike protein in endotheliopathy
Trends in Microbiology, 2023 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of for the Coronavirus Disease 2019 (COVID-19), primarily affects the epithelial compartment in the upper and lower airways.
Luca Perico, A. Benigni, G. Remuzzi
semanticscholar +1 more source
Hepatic Medicine: Evidence and Research, 2021 Daniel P Collins,1 Clifford J Steer2,3 1CMDG, LLC, Saint Paul, MN, USA; 2Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA; 3Department of Genetics, Cell Biology and Development, University of Minnesota Medical School ...
Collins DP, Steer CJ
doaj
Grain zinc, iron and protein concentrations and zinc-efficiency in wild emmer wheat under contrasting irrigation regimes [PDF]
, 2008 Micronutrient malnutrition, and particularly deficiency in zinc (Zn) and iron (Fe), afflicts over three billion people worldwide, and nearly half of the world’s cereal-growing area is affected by soil Zn deficiency.
Cakmak, Ismail +8 more
core +1 more source
Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design
Viruses, 2021 The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to gain entry into a cell to initiate infection. Both Pfizer/BioNTech’s BNT162b2 and Moderna’s mRNA-1273 vaccine candidates are based on stabilized mRNA encoding prefusion ...
X. Xia
semanticscholar +1 more source
Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomain
Nature Communications, 2022 The omicron variant of SARS-CoV-2 has been spreading rapidly across the globe. The virus-surface spike protein plays a critical role in the cell entry and immune evasion of SARS-CoV-2.
G. Ye, Bin Liu, Fangxing Li
semanticscholar +1 more source
Mutations in the SARS CoV2 Spike Gene and Their Reflections on the Spike Protein
Clinical and Experimental Health Sciences, 2021 Objective: In this study, it was aimed to determine the mutation frequency in spike (S) genes of SARS CoV2 from six different regions of the world, their distribution on the gene and reflections of these mutations to the S protein. Materials and methods: SARS CoV2 S gene sequences originating from Asia, Africa, Europe, South America, Oceania and North ...
ÇAĞLAYAN, Elif, TURAN, Kadir
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Biological Procedures Online, 2021 Background The Interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with Angiotensin converting enzyme 2 (ACE2) on the host cells is a crucial step for the viral entry and infection.
Yuning Shang +6 more
doaj +1 more source
Frontiers in Immunology, 2022 Since first reported in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly acquiring mutations, particularly in the spike protein, that can modulate pathogenicity, transmission and antibody evasion leading to successive waves ...
Mohanraj Manangeeswaran +13 more
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