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Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage [PDF]
, 2012 © 2012 Millet et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Béatrice Nal +66 more
core +1 more source
bioRxiv, 2020 SARS-CoV-2 enters cells using its Spike protein, which is also the main target of neutralizing antibodies. Therefore, assays to measure how antibodies and sera affect Spike-mediated viral infection are important for studying immunity.
K. H. Crawford +13 more
semanticscholar +1 more source
Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design
Viruses, 2021 The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to gain entry into a cell to initiate infection. Both Pfizer/BioNTech’s BNT162b2 and Moderna’s mRNA-1273 vaccine candidates are based on stabilized mRNA encoding prefusion ...
X. Xia
semanticscholar +1 more source
Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH-and Cysteine Protease-Independent Fc gamma R Pathway [PDF]
, 2011 Copyright © 2011, American Society for Microbiology. All Rights Reserved.Public health measures successfully contained outbreaks of the severe acute respiratory syndrome coronavirus (SARS-CoV) infection.
Cheung, Chung y +40 more
core +1 more source
Allosteric Regulation of SARS-CoV-2 Spike Protein Revealed by Contrastive Machine Learning
, 2023 Allosteric regulation is common in protein-protein interactions and thus can be used in drug design. Nevertheless, the mechanism of allosteric regulation remains elusive for most proteins, including SARS-CoV-2 spike protein, despite extensive ...
Tao, Wei +4 more
core +1 more source
Circulating Spike protein detected in post-COVID-19 mRNA vaccine myocarditis
Circulation, 2023 Background: Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these ...
L. Yonker +22 more
semanticscholar +1 more source
Spike protein of SARS-CoV-2 suppresses gonadotrophin secretion from bovine anterior pituitaries
The Journal of Reproduction and Development, 2022 Coronavirus disease (COVID-19), the ongoing global pandemic, is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent evidence shows that the virus utilizes angiotensin-converting enzyme 2 (ACE2) as a spike protein receptor ...
Dimas Arya ABDILLAH +4 more
doaj +1 more source
PROTEOMICS - Clinical Applications, 2023 The SARS‐CoV‐2 pandemic prompted the development and use of next‐generation vaccines. Among these, mRNA‐based vaccines consist of injectable solutions of mRNA encoding for a recombinant Spike, which is distinguishable from the wild‐type protein due to ...
Carlo Brogna +7 more
semanticscholar +1 more source
Hepatic Medicine: Evidence and Research, 2021 Daniel P Collins,1 Clifford J Steer2,3 1CMDG, LLC, Saint Paul, MN, USA; 2Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA; 3Department of Genetics, Cell Biology and Development, University of Minnesota Medical School ...
Collins DP, Steer CJ
doaj
Structure of SARS-CoV-2 spike protein
Current Opinion in Virology, 2021 The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and devastating socio-economic consequences worldwide. The disease has created urgent needs for intervention strategies to control the crisis and meeting these needs requires a deep ...
Jun Zhang +3 more
openaire +2 more sources