Results 51 to 60 of about 294,785 (311)

Relative Mutant N501Y SARS-CoV-2 Spike Protein RBD Inhibition of Anti-Spike Protein IgG and ACE-2 Binding to Spike Protein Species [PDF]

, 2021
ABSTRACT In the SARS-CoV-2 coronavirus pandemic of 2019 (COVID-19), it has become evident that the ACE-2 receptor-binding domain (RBD) of the viral spike protein (SP) is the target of neutralizing antibodies that comprise a critical element of protective immunity to the virus.
Melvin E. Klegerman, Jeffrey D. Cirillo, David D. McPherson   +2 more
openaire   +1 more source

In vitro Selection of an Aptamer Targeting SARS-CoV-2 Spike Protein with Nanopore Sequence Identification Reveals Discrimination Between the Authentic Strain and Omicron [PDF]

, 2022
DNA aptamers are oligonucleotides specifically bound to target molecules that can serve as antibodies of nucleic acid nature. For diagnosing the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), methods using antibodies specific ...
Denis, Kolesov, Lyudmila, Nikiforova, Timofei, Zatsepin, Maria, Sinegubova, Fedor, Grabovenko, Maria, Khrenova, Nadezhda, Orlova, Maria, Zvereva, Elena, Zavyalova, Vera, Spiridonova   +9 more
core   +1 more source

Computer-Aided Approaches to De Novo Design of drug candidates targeting the SARS-CoV-2 Spike protein bound to angiotensin converting enzyme 2 (ACE2) [PDF]

, 2021
In this study a computer-aided approach to de novo design of chemical entities with drug-like properties against the SARS-CoV-2 Spike protein bound to ACE2 is presented. A structure-based de novo drug design tool LIGANN was used to produce complementary
Konstantinos, Kalamatianos
core   +1 more source

Assembly of Spikes into Coronavirus Particles Is Mediated by the Carboxy-Terminal Domain of the Spike Protein

Journal of Virology, 2000
ABSTRACT The type I glycoprotein S of coronavirus, trimers of which constitute the typical viral spikes, is assembled into virions through noncovalent interactions with the M protein. Here we demonstrate that incorporation is mediated by the short carboxy-terminal segment comprising the transmembrane and endodomain.
Godeke, G J, de Haan, C A, Rossen, J W, Vennema, H, Rottier, P J   +4 more
openaire   +5 more sources

Structure of SARS-CoV-2 spike protein

Current Opinion in Virology, 2021
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and devastating socio-economic consequences worldwide. The disease has created urgent needs for intervention strategies to control the crisis and meeting these needs requires a deep ...
Jun Zhang, Tianshu Xiao, Yongfei Cai, Bing Chen   +3 more
openaire   +2 more sources

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity [PDF]

Nature Communications, 2020
Abstract SARS-CoV-2 variants with spike (S)-protein D614G mutations now predominate globally. We therefore compare the properties of the mutated S protein (S G614 ) with the original (S D614 ). We report here pseudoviruses carrying S
Zhang, Lizhou, Jackson, Cody B., Mou, Huihui, Ojha, Amrita, Peng, Haiyong, Quinlan, Brian D., Rangarajan, Erumbi S., Pan, Andi, Vanderheiden, Abigail, Suthar, Mehul S., Li, Wenhui, Izard, Tina, Rader, Christoph, Farzan, Michael, Choe, Hyeryun   +14 more
openaire   +3 more sources

Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System

Biological Procedures Online, 2021
Background The Interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein with Angiotensin converting enzyme 2 (ACE2) on the host cells is a crucial step for the viral entry and infection.
Yuning Shang, Feixiang Chen, Shasha Li, Lijuan Song, Yunzhen Gao, Xinhua Yu, Junfeng Zheng   +6 more
doaj   +1 more source

The inhibitory effect of a Corona virus spike protein fragment with ACE2 [PDF]

Biophysical Journal, 2020
ABSTRACT In this paper, we investigate the molecular assembly processes of a Coronavirus Spike protein fragment, the hexapeptide YKYRYL on the ACE2 receptor and its inhibitory effect on the aggregation and activation of the CoV-2 spike receptor protein at the same receptor protein.
Peter, Emanuel K., Schug, Alexander
openaire   +3 more sources

ChAdOx1 nCoV-19 (AZD1222) or nCoV-19-Beta (AZD2816) protect Syrian hamsters against Beta Delta and Omicron variants

Nature Communications, 2022
Whilst the ChAdOx1 nCoV-19 (AZD1222) vaccine has demonstrated efficacy against symptomatic disease, variants of concern (VOCs) with spike protein substitutions have led researchers to explore updating vaccines from ancestral spike protein.
Neeltje van Doremalen, Jonathan E. Schulz, Danielle R. Adney, Taylor A. Saturday, Robert J. Fischer, Claude Kwe Yinda, Nazia Thakur, Joseph Newman, Marta Ulaszewska, Sandra Belij-Rammerstorfer, Greg Saturday, Alexandra J. Spencer, Dalan Bailey, Colin A. Russell, Sarah C. Gilbert, Teresa Lambe, Vincent J. Munster   +16 more
doaj   +1 more source

Existence and stability analysis of spiky solutions for the Gierer-Meinhardt system with large reaction rates [PDF]

, 2009
We study the Gierer-Meinhardt system in one dimension in the limit of large reaction rates. First we construct three types of solutions: (i) an interior spike; (ii) a boundary spike and (iii) two boundary spikes.
Winter, M, Juncheng Wei, Matthias Winter, Theodore Kolokolnikov, Kolokolnikov, T, Wei, J   +5 more
core   +1 more source