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Adaptive Evolution of the Spike Protein in Coronaviruses

Molecular Biology and Evolution, 2023
Abstract Coronaviruses are single-stranded, positive-sense RNA viruses that can infect many mammal and avian species. The Spike (S) protein of coronaviruses binds to a receptor on the host cell surface to promote viral entry. The interactions between the S proteins of coronaviruses and receptors of host cells are extraordinarily complex,
Xiaolu Tang, Zhaohui Qian, Xuemei Lu, Jian Lu   +3 more
openaire   +2 more sources

Allosteric Regulation of SARS-CoV-2 Spike Protein Revealed by Contrastive Machine Learning [PDF]

, 2023
Allosteric regulation is common in protein-protein interactions and thus can be used in drug design. Nevertheless, the mechanism of allosteric regulation remains elusive for most proteins, including SARS-CoV-2 spike protein, despite extensive ...
Tao, Wei, Yong, Wei, Amy, Chen, Yuewei, Lin, Baofu, Qiao   +4 more
core   +1 more source

Amyloidogenesis of SARS-CoV-2 Spike Protein [PDF]

Journal of the American Chemical Society, 2021
ABSTRACT SARS-CoV-2 infection is associated with a surprising number of morbidities. Uncanny similarities with amyloid-disease associated blood coagulation and fibrinolytic disturbances together with neurologic and cardiac problems led us to investigate the amyloidogenicity of the SARS-CoV-2 Spike protein (S-protein).
Sofie Nyström, Per Hammarström
openaire   +2 more sources

A Fusion Peptide in the Spike Protein of MERS Coronavirus [PDF]

Viruses, 2019
Coronaviruses represent current and emerging threats for many species, including humans. Middle East respiratory syndrome-related coronavirus (MERS-CoV) is responsible for sporadic infections in mostly Middle Eastern countries, with occasional transfer elsewhere.
Entedar A. J. Alsaadi, Benjamin W. Neuman, Ian M. Jones   +2 more
openaire   +4 more sources

Protein Footprinting, Conformational Dynamics and Interface-Adjacent Neutralization ‘Hotspots’ in the SARS-CoV-2 Spike Protein Receptor Binding Domain / Human ACE2 Interaction [PDF]

, 2020
This study provides an HDX-MS based analysis of the interaction between the SARS-CoV-2 spike protein and the human Angiotensin Converting Enzyme 2. - The data agree exactly with the X-ray co-crystal structure of this complex, but provide additional ...
Dominic, Narang, Derek, Wilson, Matthew, Balmer, D. Andrew, James   +3 more
core   +1 more source

HUMAN SARS CoV-2 SPIKE PROTEIN MUTATIONS [PDF]

, 2020
The human SARS-CoV-2 spike protein sequences from Asia, Africa, Europe, North America, South America and Oceania were analyzed by comparing with the reference SARS-CoV-2 protein sequence from Wuhan-Hu-1, China.
Lalitha, Guruprasad
core   +1 more source

Mutations and Evolution of the SARS-CoV-2 Spike Protein

Viruses, 2022
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the viral infection that leads to various levels of COVID-19 severities. Positive evolutionary selection of mutations within the spike protein has led to the genesis
Nicholas Magazine, Tianyi Zhang, Yingying Wu, Michael C. McGee, Gianluca Veggiani, Weishan Huang   +5 more
doaj   +1 more source

Myxobacterial Depsipeptide Chondramides Interrupt SARS-CoV-2 Entry by Targeting Its Broad, Cell Tropic Spike Protein: Antagonistic Prospects for Anti-COVID-19 Drug Discovery [PDF]

, 2021
The severity of the COVID-19 pandemic necessitated the search for drugs against the causative viral agent, SARS-CoV-2. Among the promising targets is the viral surface of SARS-CoV-2 adorned by spike proteins appearing as crown-like structures known for ...
Joe Anthony, Manzano, Von Novi, de Leon, Delfin Yñigo H., Pilapil, Omar, Villalobos, Mark Tristan J., Quimque, Kin Israel, Notarte, John Jeric P. San, Jose, Allan Patrick, Macabeo, Rey Arturo T., Fernandez   +8 more
core   +1 more source

Production and secretion of functional SARS-CoV-2 spike protein in Chlamydomonas reinhardtii

Frontiers in Plant Science, 2022
The spike protein is the major protein on the surface of coronaviruses. It is therefore the prominent target of neutralizing antibodies and consequently the antigen of all currently admitted vaccines against SARS-CoV-2.
Anna Maria Kiefer, Justus Niemeyer, Anna Probst, Gerhard Erkel, Michael Schroda   +4 more
doaj   +1 more source

Molecular Evolutionary Analyses of the Spike Protein Gene and Spike Protein in the SARS-CoV-2 Omicron Subvariants

Microorganisms, 2023
To better understand the evolution of the SARS-CoV-2 Omicron subvariants, we performed molecular evolutionary analyses of the spike (S) protein gene/S protein using advanced bioinformatics technologies. First, time-scaled phylogenetic analysis estimated that a common ancestor of the Wuhan, Alpha, Beta, Delta variants, and Omicron variants/subvariants ...
Norika Nagasawa, Ryusuke Kimura, Mao Akagawa, Tatsuya Shirai, Mitsuru Sada, Kaori Okayama, Yuka Sato-Fujimoto, Makoto Saito, Mayumi Kondo, Kazuhiko Katayama, Akihide Ryo, Makoto Kuroda, Hirokazu Kimura   +12 more
openaire   +3 more sources