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International Journal of Molecular Sciences, 2023 Several studies report elevated blood platelet activation and altered platelet count in COVID-19 patients, but the role of the SARS-CoV-2 spike protein in this process remains intriguing. Additionally, there is no data that anti-SARS-CoV-2 neutralizing antibodies (nAb) may attenuate spike protein activity toward blood platelets.
Boguslawa Luzak +6 more
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Frontiers in Virology, 2023 IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine ...
Neale Harrison +24 more
doaj +1 more source
bioRxiv, 2020 The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 800 laboratory-confirmed human infections, including 25 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine.
Xiao-long Tian +10 more
semanticscholar +1 more source
Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein
bioRxiv, 2021 Emerging SARS-CoV-2 variants, especially those of concern, may have an impact on the virus’s transmissibility and pathogenicity, as well as diagnostic equipment performance and vaccine effectiveness.
Suresh Kumar +3 more
semanticscholar +1 more source
Cells, 2021 Coronaviruses such as SARS-CoV-2, which is responsible for COVID-19, depend on virus spike protein binding to host cell receptors to cause infection. The SARS-CoV-2 spike protein binds primarily to ACE2 on target cells and is then processed by membrane ...
Lynda J. Partridge +5 more
doaj +1 more source
Science, 2020 An antibody cocktail against SARS-CoV-2 There is an urgent focus on antibodies that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike and prevent the virus from entering host cells. Hansen et al.
A. Baum +15 more
semanticscholar +1 more source
Acta Pharmacologica Sinica, 2020 Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Yuan Huang +4 more
semanticscholar +1 more source
Cell Reports, 2023 Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019 (COVID-19) syndrome, but its underlying mechanisms are not completely understood.
F. Fontes-Dantas +24 more
semanticscholar +1 more source
Prefusion spike protein stabilization through computational mutagenesis [PDF]
Proteins: Structure, Function, and Bioinformatics, 2020 ABSTRACTA novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) has emerged as a human pathogen, causing global pandemic and resulting in over 400,000 deaths worldwide. The surface spike protein of SARS-CoV-2 mediates the process of coronavirus entry into human cells by binding angiotensin-converting enzyme 2 (ACE2).
Zhang, Dong Yan +2 more
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Frontiers in Chemistry, 2021 Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). As of October 21, 2020, more than 41.4 million confirmed cases and 1.1 million deaths have been reported.
Sugunadevi Sakkiah +8 more
doaj +1 more source