Results 21 to 30 of about 3,974,865 (310)

Enhancing epitope of PEDV spike protein

Frontiers in Microbiology, 2022
Porcine epidemic diarrhea virus (PEDV) is the causative agent of a highly contagious enteric disease of pigs characterized by diarrhea, vomiting, and severe dehydration. PEDV infects pigs of all ages, but neonatal pigs during the first week of life are highly susceptible; the mortality rates among newborn piglets may reach 80–100%.
Techit Thavorasak, Techit Thavorasak, Monrat Chulanetra, Kittirat Glab-ampai, Kodchakorn Mahasongkram, Nawannaporn Sae-lim, Karsidete Teeranitayatarn, Thaweesak Songserm, Rungrueang Yodsheewan, Dachrit Nilubol, Dachrit Nilubol, Wanpen Chaicumpa, Nitat Sookrung, Nitat Sookrung   +13 more
openaire   +3 more sources

A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein Mutations

COVID, 2023
The emergence of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has sparked intense research on its spike protein, which is essential for viral entrance into host cells.
Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha, Rene B. Khan, Hezekiel M. Kumalo   +4 more
doaj   +1 more source

Different In Silico Approaches Using Heterocyclic Derivatives against the Binding between Different Lineages of SARS-CoV-2 and ACE2

Molecules, 2023
Over the last few years, the study of the SARS-CoV-2 spike protein and its mutations has become essential in understanding how it interacts with human host receptors.
Federica Sipala, Gianfranco Cavallaro, Giuseppe Forte, Cristina Satriano, Alessandro Giuffrida, Aurore Fraix, Angelo Spadaro, Salvatore Petralia, Carmela Bonaccorso, Cosimo Gianluca Fortuna, Simone Ronsisvalle   +10 more
doaj   +1 more source

501Y.V2 Spike Protein Resists the Antibody in Atomistic Simulations [PDF]

, 2021
SARS-CoV-2 Spike (S) protein is a major biological target for COVID-19 vaccine design. Unfortunately, recent reports indicated that Spike (S) protein mutations can lead to antibody resistance.
Son Tung, Ngo
core   +1 more source

FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

Journal of Lipid Research, 2022
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues.
Katrina Mekhail, Minhyoung Lee, Michael Sugiyama, Audrey Astori, Jonathan St-Germain, Elyse Latreille, Negar Khosraviani, Kuiru Wei, Zhijie Li, James Rini, Warren L. Lee, Costin Antonescu, Brian Raught, Gregory D. Fairn   +13 more
doaj   +1 more source

Adaptive Evolution of the Spike Protein in Coronaviruses

Molecular Biology and Evolution, 2023
Abstract Coronaviruses are single-stranded, positive-sense RNA viruses that can infect many mammal and avian species. The Spike (S) protein of coronaviruses binds to a receptor on the host cell surface to promote viral entry. The interactions between the S proteins of coronaviruses and receptors of host cells are extraordinarily complex,
Xiaolu Tang, Zhaohui Qian, Xuemei Lu, Jian Lu   +3 more
openaire   +2 more sources

Protein Footprinting, Conformational Dynamics and Interface-Adjacent Neutralization ‘Hotspots’ in the SARS-CoV-2 Spike Protein Receptor Binding Domain / Human ACE2 Interaction [PDF]

, 2020
This study provides an HDX-MS based analysis of the interaction between the SARS-CoV-2 spike protein and the human Angiotensin Converting Enzyme 2. - The data agree exactly with the X-ray co-crystal structure of this complex, but provide additional ...
Dominic, Narang, Derek, Wilson, Matthew, Balmer, D. Andrew, James   +3 more
core   +1 more source

A cell-based, SARS-CoV-2 spike protein interaction assay to inform the neutralising capacity of recombinant and patient sera antibodies

Frontiers in Virology, 2023
IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine ...
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J. Hill, Aekkachai Tuekprakhon, Zhi Li, Cristina Matas de las Heras, Ana Teodosio, Andrea S. Lavado, Robert Moring, Ayesha Ashraf, Timothy R. Dafforn, Dimitris K. Grammatopoulos, Dimitris K. Grammatopoulos, John Gordon, Catherine A. Brady, Lawrence S. Young, Nicholas M. Barnes, Nicholas M. Barnes, Zania Stamataki, Omar S. Qureshi   +24 more
doaj   +1 more source

Spike-Fusion protein similarity region on spike protein.

, 2021
SARS-CoV-2 spike schematic model with paramyxovirus sequence similarity region shown with pale blue bar (residues 810 to 1098) (a). Corresponding area is shown in red on SARS-CoV-2 spike 3D structure (b).
Ehsan Ahmadi (2804020), Farshid Noorbakhsh (3843898), Mohammad Reza Zabihi (11785719), Ramin Hosseinzadeh (11785722), Leila Mohamed Khosroshahi (11785725)   +4 more
core   +1 more source

Repurposing Therapeutics for COVID-19: Supercomputer-Based Docking to the SARS-CoV-2 Viral Spike Protein and Viral Spike Protein-Human ACE2 Interface [PDF]

, 2020
The novel Wuhan coronavirus (SARS-CoV-2) has been sequenced, and the virus shares substantial similarity with SARS-CoV. Here, using a computational model of the spike protein (S-protein) of SARS-CoV-2 interacting with the human ACE2 receptor, we make use
Jeremy C., Smith, Micholas, Smith, Jeremy C. Smith (8467509), Micholas Smith (8464173)   +3 more
core   +1 more source