Results 21 to 30 of about 7,075,307 (355)

Adaptive Evolution of the Spike Protein in Coronaviruses

Molecular Biology and Evolution, 2023
Abstract Coronaviruses are single-stranded, positive-sense RNA viruses that can infect many mammal and avian species. The Spike (S) protein of coronaviruses binds to a receptor on the host cell surface to promote viral entry. The interactions between the S proteins of coronaviruses and receptors of host cells are extraordinarily complex,
Xiaolu Tang, Zhaohui Qian, Xuemei Lu, Jian Lu   +3 more
openaire   +2 more sources

FASN inhibitor TVB-3166 prevents S-acylation of the spike protein of human coronaviruses

Journal of Lipid Research, 2022
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses mediates host cell entry and is S-acylated on multiple phylogenetically conserved cysteine residues.
Katrina Mekhail, Minhyoung Lee, Michael Sugiyama, Audrey Astori, Jonathan St-Germain, Elyse Latreille, Negar Khosraviani, Kuiru Wei, Zhijie Li, James Rini, Warren L. Lee, Costin Antonescu, Brian Raught, Gregory D. Fairn   +13 more
doaj   +1 more source

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

Molecules and Cells, 2020
The pandemic coronavirus SARS-CoV-2 threatens public health worldwide. The viral spike protein mediates SARS-CoV-2 entry into host cells and harbors a S1/S2 cleavage site containing multiple arginine residues (multibasic) not found in closely related ...
M. Hoffmann, Hannah Kleine-Weber, S. Pöhlmann   +2 more
semanticscholar   +1 more source

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

Science China Life Sciences, 2020
Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai 200031, China; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant ...
Xintian Xu, Ping Chen, Jingfang Wang, Jiannan Feng, Hui Zhou, Xuan Li, Wu Zhong, Pei Hao   +7 more
semanticscholar   +1 more source

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Science, 2020
Hitting SARS-CoV-2 in a new spot A key target for therapeutic antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the spike protein, a trimeric protein complex with each monomer comprising an S1 and an S2 domain that ...
Xiangyang Chi, R. Yan, Jun Zhang, Guanying Zhang, Yuanyuan Zhang, Meng Hao, Zhe Zhang, Pengfei Fan, Yunzhu Dong, Yilong Yang, Zhengshan Chen, Yingying Guo, Jinlong Zhang, Yaning Li, Xiaohong Song, Yi Chen, L. Xia, L. Fu, L. Hou, Junjie Xu, Changming Yu, Jianmin Li, Qiang Zhou, Wei Chen   +23 more
semanticscholar   +1 more source

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

bioRxiv, 2020
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 800 laboratory-confirmed human infections, including 25 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine.
Xiao-long Tian, Cheng Li, Ailing Huang, Shuai Xia, Sicong Lu, Zhènglì Shí, Lu Lu, Shibo Jiang, Zhenlin Yang, Yanling Wu, T. Ying   +10 more
semanticscholar   +1 more source

A cell-based, SARS-CoV-2 spike protein interaction assay to inform the neutralising capacity of recombinant and patient sera antibodies

Frontiers in Virology, 2023
IntroductionThe engagement of the SARS-CoV-2 spike protein with ACE2 is a critical step for viral entry to human cells, and, therefore, blocking this interaction is a major determinant of the efficacy of monoclonal antibody therapeutics and vaccine ...
Neale Harrison, Lauren Richardson, Chiara Pallini, Ines Morano, Elizabeth Jinks, Jamie Cowley, Hujo Chan, Harriet J. Hill, Aekkachai Tuekprakhon, Zhi Li, Cristina Matas de las Heras, Ana Teodosio, Andrea S. Lavado, Robert Moring, Ayesha Ashraf, Timothy R. Dafforn, Dimitris K. Grammatopoulos, Dimitris K. Grammatopoulos, John Gordon, Catherine A. Brady, Lawrence S. Young, Nicholas M. Barnes, Nicholas M. Barnes, Zania Stamataki, Omar S. Qureshi   +24 more
doaj   +1 more source

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Science, 2020
An antibody cocktail against SARS-CoV-2 There is an urgent focus on antibodies that target the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral spike and prevent the virus from entering host cells. Hansen et al.
A. Baum, Benjamin O. Fulton, Elzbieta Wloga, R. Copin, Kristen E. Pascal, Vincenzo Russo, Stephanie Giordano, Kathryn Lanza, Nicole Negron, M. Ni, Yi Wei, G. Atwal, A. Murphy, N. Stahl, G. Yancopoulos, C. Kyratsous   +15 more
semanticscholar   +1 more source

Omicron and Delta Variant of SARS-CoV-2: A Comparative Computational Study of Spike protein

bioRxiv, 2021
Emerging SARS-CoV-2 variants, especially those of concern, may have an impact on the virus’s transmissibility and pathogenicity, as well as diagnostic equipment performance and vaccine effectiveness.
Suresh Kumar, Thiviya S. Thambiraja, Kalimuthu Karuppanan, Gunasekaran Subramaniam   +3 more
semanticscholar   +1 more source

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

Acta Pharmacologica Sinica, 2020
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Yuan Huang, C. Yang, Xinfeng Xu, W. Xu, Shuwen Liu   +4 more
semanticscholar   +1 more source