Results 31 to 40 of about 40,476 (180)

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance The pandemic potential of coronaviruses was recently demonstrated twice by global outbreaks of deadly pneumonia. The spike (S) glycoprotein initiates infection through conformational changes that remain largely uncharacterized. Here we report the cryoEM structure of an S glycoprotein in the postfusion state, showing large-scale ...
Walls, Alexandra, Tortorici, M. Alejandra, Snijder, Joost, Xiong, Xiaoli, Bosch, Berend-Jan, Rey, Félix A., Veesler, David   +6 more
openaire   +4 more sources

Inhibitory potentials of ivermectin, nafamostat, and camostat on spike protein and some nonstructural proteins of SARS-CoV-2: Virtual screening approach

Jurnal Teknologi Laboratorium, 2022
The search for potent oral drugs either through synthetic routes or by drug repurposing for combating the dreaded covid-19 virus is still ongoing. The coronavirus spike glycoprotein and several other non-structural proteins play crucial roles in the ...
Haruna Isiyaku Umar, Ijeoma Akunna Duru, Uchechi Emmanuela Enenebeaku, Lynda Chioma Ngozi Olehi, Christian Ebere Enyoh, Chidi Edbert Duru   +5 more
doaj   +1 more source

High-Potency Polypeptide-based Interference for Coronavirus Spike Glycoproteins [PDF]

, 2021
Abstract The world is experiencing an unprecedented coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 spike protein-based vaccines are currently the main preventive agent to fight against the virus.
Qinghua Wang, Jianpeng Ma, Adam Acevedo
openaire   +1 more source

Immunogenicity of a recombinant coronavirus spike glycoprotein expressed in transgenic plants [PDF]

Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz, 2000
Recently, it has been demonstrated that plants offer the possibility of producing low cost subunit vaccines that can be either parenterally or orally administered. Here we review data we obtained on the immunological response elicited by two recombinant versions of the glycoprotein S from the swine transmissible gastroenteritis coronavirus (TGEV ...
Escribano, J.M., Borca, M.V.
openaire   +1 more source

LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus

Virology, 2005
Cellular attachment factors like the C-type lectins DC-SIGN and DC-SIGNR (collectively referred to as DC-SIGN/R) can augment viral infection and might promote viral dissemination in and between hosts. The lectin LSECtin is encoded in the same chromosomal locus as DC-SIGN/R and is coexpressed with DC-SIGNR on sinusoidal endothelial cells in liver and ...
Gramberg, Thomas, Hofmann, Heike, Möller, Peggy, Lalor, Patricia F., Marzi, Andrea, Geier, Martina, Krumbiegel, Mandy, Winkler, Thomas, Kirchhoff, Frank, Adams, David H., Becker, Stephan, Münch, Jan, Pöhlmann, Stefan   +12 more
openaire   +2 more sources

Missense mutations in spike protein of SARS‐CoV‐2 delta variant contribute to the alteration in viral structure and interaction with hACE2 receptor

Immunity, Inflammation and Disease, 2022
Introduction Many of the global pandemics threaten human existence over the decades among which coronavirus disease (COVID‐19) is the newest exposure circulating worldwide.
Tousif Bin Mahmood, Mohammad Imran Hossan, Shafi Mahmud, Mst. Sharmin Sultana Shimu, Md. Jahidul Alam, Md. Mahfuzur Rahman Bhuyan, Talha Bin Emran   +6 more
doaj   +1 more source

Molecular docking and dynamic simulation of conserved B cell epitope of SARS-CoV-2 glycoprotein Indonesian isolates: an immunoinformatic approach [version 1; peer review: 3 approved]

F1000Research, 2021
Background: An immunoinformatic approach may be useful to investigate the conserved region in the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Indonesia isolates.
Fedik Abdul Rantam, Viol Dhea Kharisma, Christrijogo Sumartono, Jusak Nugraha, Andi Yasmin Wijaya, Helen Susilowati, Suryo Kuncorojakti, Alexander Patera Nugraha   +7 more
doaj   +1 more source

Properties of Coronavirus IBV After Removal of the S1 Subunit of the Spike Glycoprotein [PDF]

, 1987
Our recent investigations of avian infectious bronchitis virus (IBV) have concentrated on the biological properties of the spike (S) glycoprotein. Previously we showed that the mature S is derived by cleavage of a precursor glycoprotein to yield two glycopolypeptides, S1 and S2 of approximately 514 and 625 amino acid residues respectively1.
D, Cavanagh, P, Davis
openaire   +2 more sources

Treatment with Exogenous Trypsin Expands In Vitro Cellular Tropism of the Avian Coronavirus Infectious Bronchitis Virus

Viruses, 2020
The Gammacoronavirus infectious bronchitis virus (IBV) causes a highly contagious and economically important respiratory disease in poultry. In the laboratory, most IBV strains are restricted to replication in ex vivo organ cultures or in ovo and do not ...
Phoebe Stevenson-Leggett, Sarah Keep, Erica Bickerton   +2 more
doaj   +1 more source

Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2. [PDF]

PLoS Pathogens, 2018
The trimeric SARS coronavirus (SARS-CoV) surface spike (S) glycoprotein consisting of three S1-S2 heterodimers binds the cellular receptor angiotensin-converting enzyme 2 (ACE2) and mediates fusion of the viral and cellular membranes through a pre- to ...
Wenfei Song, Miao Gui, Xinquan Wang, Ye Xiang   +3 more
doaj   +1 more source