Results 11 to 20 of about 40,476 (180)

Potential Therapeutic Targeting of Coronavirus Spike Glycoprotein Priming [PDF]

Molecules, 2020
Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2′) cleavage sites that are processed by human host proteases.
Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin, Maurizio Pellecchia   +5 more
doaj   +3 more sources

Cetacean coronavirus spikes highlight S glycoprotein structural plasticity. [PDF]

PLoS Pathog
Abstract Coronaviruses (CoVs) exhibit a remarkable ability for spill-over infections into naive host populations. While much research has focused on the spike (S) glycoproteins of zoonotic alpha- and betacoronaviruses, the S proteins of gamma- and deltacoronaviruses, which predominantly infect avian hosts, remain ...
Hulswit RJG, Shamorkina TM, van der Lee J, Rosman F, Wetzels LS, van Kuppeveld FJM, Snijder J, Bosch BJ, Hurdiss DL.   +8 more
europepmc   +2 more sources

An Overview of Spike Surface Glycoprotein in Severe Acute Respiratory Syndrome–Coronavirus [PDF]

Frontiers in Molecular Biosciences, 2021
The novel coronavirus originated in December 2019 in Hubei, China. This contagious disease named as COVID-19 resulted in a massive expansion within 6 months by spreading to more than 213 countries. Despite the availability of antiviral drugs for the treatment of various viral infections, it was concluded by the WHO that there is no medicine to treat ...
Muthu Kumaradoss Kathiravan, Muthu Kumaradoss Kathiravan, Srimathi Radhakrishnan, Srimathi Radhakrishnan, Vigneshwaran Namasivayam, Senthilkumar Palaniappan   +5 more
openaire   +3 more sources

Closing coronavirus spike glycoproteins by structure-guided design [PDF]

, 2020
The recent spillover of SARS-CoV-2 in the human population resulted in the ongoing COVID-19 pandemic which has already caused 4.9 million infections and more than 326,000 fatalities. To initiate infection the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface, determining host and tissue tropism, and fusion of the viral and ...
McCallum, Matthew, Walls, Alexandra C., Corti, Davide, Veesler, David   +3 more
openaire   +2 more sources

Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus [PDF]

Virologica Sinica, 2010
A group of SARS-like coronaviruses (SL-CoV) have been identified in horseshoe bats. Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental
Hou, Yu-xuan, Peng, Cheng, Han, Zheng-gang, Zhou, Peng, Chen, Ji-guo, Shi, Zheng-li   +5 more
openaire   +2 more sources

Expression of SARS-coronavirus spike glycoprotein in Pichia pastoris [PDF]

Virus Genes, 2008
To establish a rapid and economical method for the expression of viral proteins in high yield and purity by Pichia pastoris, the S protein of the SARS-CoV was selected in this study. Six S glycoprotein fragments were expressed in Escherichia coli BL21 and yeast KM71H strains.
Chuck, Chi-Pang, Wong, Chi-Hang, Chow, Larry Ming-Cheung, Fung, Kwok-Pui, Waye, Mary Miu-Yee, Tsui, Stephen Kwok-Wing   +5 more
openaire   +2 more sources

Therapeutic targeting of coronavirus spike glycoprotein priming [PDF]

, 2020
Abstract Processing of certain viral proteins and bacterial toxins by host serine proteases is a frequent and critical step in virulence. The coronavirus spike glycoprotein contains three (S1, S2, and S2’) cleavage sites that are processed by human host proteases.
Maurizio Pellecchia, Elisa Barile, Carlo Baggio, Luca Gambini, Sergey A. Shiryaev, Alex Y. Strongin   +5 more
openaire   +1 more source

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

Viruses, 2021
The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells.
Eun Jeong Park, Phyoe Kyawe Myint, Michael Gyasi Appiah, Samuel Darkwah, Siqingaowa Caidengbate, Atsushi Ito, Eri Matsuo, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +9 more
doaj   +1 more source

Genetic Variant of SARS-CoV-2 Isolates in Indonesia: Spike Glycoprotein Gene

Journal of Pure and Applied Microbiology, 2020
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a novel coronavirus and the primary causative agent of coronavirus disease 2019 (COVID-19), first occurred in China and rapidly spread worldwide.
Arif Nur Muhammad Ansori, Viol Dhea Kharisma, Sahal Sabilil Muttaqin, Yulanda Antonius, Arli Aditya Parikesit   +4 more
doaj   +1 more source

Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein [PDF]

, 2006
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) mediates attachment, receptor engagement and entry via its spike glycoprotein (S). S-dependent viral entry requires the presence of a primary receptor, angiotensin converting enzyme-2 (ACE2), while the C-type lectins, DC-SIGN, DC-SIGNR, and LSECtin act as attachment factors, promoting ...
Simmons, Graham, Rennekamp, Andrew J., Bates, Paul   +2 more
openaire   +2 more sources