Results 21 to 30 of about 51,283 (222)

High-Potency Polypeptide-based Interference for Coronavirus Spike Glycoproteins [PDF]

, 2021
Abstract The world is experiencing an unprecedented coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 spike protein-based vaccines are currently the main preventive agent to fight against the virus.
Qinghua Wang, Jianpeng Ma, Adam Acevedo
openaire   +1 more source

Immunogenicity of the spike glycoprotein of Bat SARS-like coronavirus [PDF]

Virologica Sinica, 2010
A group of SARS-like coronaviruses (SL-CoV) have been identified in horseshoe bats. Despite SL-CoVs and SARS-CoV share identical genome structure and high-level sequence similarity, SL-CoV does not bind to the same cellular receptor as for SARS-CoV and the N-terminus of the S proteins only share 64% amino acid identity, suggesting there are fundamental
Hou, Yu-xuan, Peng, Cheng, Han, Zheng-gang, Zhou, Peng, Chen, Ji-guo, Shi, Zheng-li   +5 more
openaire   +2 more sources

Proteolysis of Sars-Associated Coronavirus Spike Glycoprotein [PDF]

, 2006
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) mediates attachment, receptor engagement and entry via its spike glycoprotein (S). S-dependent viral entry requires the presence of a primary receptor, angiotensin converting enzyme-2 (ACE2), while the C-type lectins, DC-SIGN, DC-SIGNR, and LSECtin act as attachment factors, promoting ...
Simmons, Graham, Rennekamp, Andrew J., Bates, Paul   +2 more
openaire   +2 more sources

Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence [PDF]

Journal of NeuroVirology, 2001
The spike (S) glycoprotein of mouse hepatitis virus (MHV) is a major determinant of neurovirulence. Using targeted recombination we previously demonstrated that the S gene of the highly neurovirulent MHV-4 conferred a dramatic increase in neurovirulence to the mildly neurovirulent MHV-A59.
Phillips, Joanna J, Chua, MingMing, Seo, Su-hun, Weiss, Susan R   +3 more
openaire   +4 more sources

Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approaches [PDF]

Translational Medicine Communications, 2020
Abstract Background Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cronaviridae family.
Eman Ali Awadelkareem, Sumaia Awad Elkariem Ali   +1 more
openaire   +4 more sources

The Human Leukocyte Antigen Class II Immunopeptidome of the SARS-CoV-2 Spike Glycoprotein

Cell Reports, 2020
Summary: Precise elucidation of the antigen sequences for T cell immunosurveillance greatly enhances our ability to understand and modulate humoral responses to viral infection or active immunization.
Michael D. Knierman, Megan B. Lannan, Laura J. Spindler, Carl L. McMillian, Robert J. Konrad, Robert W. Siegel   +5 more
doaj   +1 more source

Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Based Novel Epitopes Induce Potent Immune Responses in vivo and Inhibit Viral Replication in vitro

Frontiers in Immunology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) initiates infection by attachment of the surface-exposed spike glycoprotein to the host cell receptors.
Preeti Vishwakarma, Naveen Yadav, Zaigham Abbas Rizvi, Naseem Ahmed Khan, Adarsh Kumar Chiranjivi, Shailendra Mani, Manish Bansal, Prabhanjan Dwivedi, Tripti Shrivastava, Rajesh Kumar, Amit Awasthi, Shubbir Ahmed, Sweety Samal   +12 more
doaj   +1 more source

The SARS-CoV-2 Spike Glycoprotein as a Drug and Vaccine Target: Structural Insights into Its Complexes with ACE2 and Antibodies

Cells, 2020
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of the Coronavirus disease (COVID-19) pandemic, has so far resulted in more than 1.1 M deaths and 40 M cases worldwide with no confirmed remedy yet available.
Anastassios C. Papageorgiou, Imran Mohsin   +1 more
doaj   +1 more source

SARS-CoV-2 prevalence in domestic and wildlife animals: A genomic and docking based structural comprehensive review

Heliyon, 2023
The SARS-CoV-2 virus has been identified as the infectious agent that led to the COVID-19 pandemic, which the world has seen very recently. Researchers have linked the SARS-CoV-2 outbreak to bats for the zoonotic spread of the virus to humans ...
Tuhin Das, Suranjana Sikdar, Md. Helal Uddin Chowdhury, Khandakar Jannatul Nyma, Md. Adnan   +4 more
doaj   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source