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Murine Coronavirus Spike Glycoprotein [PDF]
, 2001 The mature Coronavirus spike is a large, oligomeric, type I integral membrane glycoprotein that projects about 20 nm from the surface of infected cells and virions. In this extracellular position, the spikes function to bind the cellular receptors extending from opposing membranes.
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Mutagenesis of the transmembrane domain of the SARS coronavirus spike glycoprotein: refinement of the requirements for SARS coronavirus cell entry [PDF]
Virology Journal, 2009 The spike protein (S) of SARS Coronavirus (SARS-CoV) mediates entry of the virus into target cells, including receptor binding and membrane fusion. Close to or in the viral membrane, the S protein contains three distinct motifs: a juxtamembrane aromatic part, a central highly hydrophobic stretch and a cysteine rich motif.
van Kasteren Puck +3 more
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Vaccine design of coronavirus spike (S) glycoprotein in chicken: immunoinformatics and computational approaches [PDF]
Translational Medicine Communications, 2020 Abstract Background Infectious bronchitis (IB) is a highly contagious respiratory disease in chickens and produces economic loss within the poultry industry. This disease is caused by a single stranded RNA virus belonging to Cronaviridae family.
Eman Ali Awadelkareem +1 more
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Advanced Biomedical Research, 2022 Background: Management of severe acute respiratory syndrome coronavirus 2 in humans depends on the availability of vaccines or effective drugs. Studies have shown that angiotensin-converting enzyme 2 (ACE2) is responsible for binding the viral spike ...
Ramin Farhoudi +5 more
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Biochemical Analysis of Coronavirus Spike Glycoprotein Conformational Intermediates during Membrane Fusion [PDF]
Journal of Virology, 2019 Recent studies using single-particle cryo-electron microscopy (cryoEM) revealed the mechanism underlying activation of viral fusion protein at the priming stage. However, characterizing the subsequent triggering stage underpinning transition from pre- to postfusion structures is difficult because single-particle cryoEM excludes unstable structures that
Kawase, Miyuki +3 more
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Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition
Frontiers in Molecular Biosciences, 2022 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes Coronavirus Disease 2019 (COVID-19), which, since 2019 in China, has rapidly become a worldwide pandemic.
Ilaria Iacobucci +15 more
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Does Early Childhood Vaccination Protect Against COVID-19?
Frontiers in Molecular Biosciences, 2020 The coronavirus disease 2019 (COVID-19) is an on-going pandemic caused by the SARS-coronavirus-2 (SARS-CoV-2) which targets the respiratory system of humans.
Karzan R. Sidiq +5 more
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Carbohydrate Ligands for COVID-19 Spike Proteins
Viruses, 2022 An outbreak of SARS-CoV-2 coronavirus (COVID-19) first detected in Wuhan, China, has created a public health emergency all over the world. The pandemic has caused more than 340 million confirmed cases and 5.57 million deaths as of 23 January 2022 ...
Yung-Kuo Lee +7 more
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Molecular and phylogenetic analysis of bovine coronavirus based on the spike glycoprotein gene
Infection, Genetics and Evolution, 2012 Bovine coronavirus has been associated with diarrhoea in newborn calves, winter dysentery in adult cattle and respiratory tract infections in calves and feedlot cattle. In Cuba, the presence of BCoV was first reported in 2006. Since then, sporadic outbreaks have continued to occur.
Martínez, Nadia +6 more
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Biology Direct, 2020 The spike glycoprotein of the SARS-CoV-2 virus, which causes COVID-19, has attracted attention for its vaccine potential and binding capacity to host cell surface receptors. Much of this research focus has centered on the ectodomain of the spike protein.
Sepehr Ehsani
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