Results 61 to 70 of about 51,283 (222)

Cryo-electron Microscopy Structure of the Swine Acute Diarrhea Syndrome Coronavirus Spike Glycoprotein Provides Insights into Evolution of Unique Coronavirus Spike Proteins

Journal of Virology, 2020
In this article, we report the atomic-resolution prefusion structure of the spike protein from swine acute diarrhea syndrome coronavirus (SADS-CoV). SADS-CoV is a pathogenic alphacoronavirus that was responsible for a large-scale outbreak of fatal disease in pigs and that was reported to be capable of interspecies transmission.
Guan, Hongxin, Wang, Youwang, Perčulija, Vanja, Saeed, Abdullah F. U. H., Liu, Yichang, Li, Jinyu, Jan, Syed Sajid, Li, Yu, Zhu, Ping, Ouyang, Songying   +9 more
openaire   +3 more sources

Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer Simulations

Frontiers in Immunology, 2021
SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1 domain of the spike glycoprotein of SARS-CoV-2 binds to human angiotensin-converting enzyme 2 (hACE2) via its receptor-binding domain, while the S2 domain facilitates fusion
Damiano Buratto, Abhishek Saxena, Qun Ji, Guang Yang, Sergio Pantano, Sergio Pantano, Francesco Zonta   +6 more
doaj   +1 more source

Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis Virus [PDF]

Journal of Virology, 2000
ABSTRACTDemyelination is the pathologic hallmark of the human immune-mediated neurologic disease multiple sclerosis, which may be triggered or exacerbated by viral infections. Several experimental animal models have been developed to study the mechanism of virus-induced demyelination, including coronavirus mouse hepatitis virus (MHV) infection in mice.
J, Das Sarma, L, Fu, J C, Tsai, S R, Weiss, E, Lavi   +4 more
openaire   +2 more sources

Structure, receptor recognition, and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

Cell, 2022
The isolation of CCoV-HuPn-2018 from a child respiratory swab indicates that more coronaviruses are spilling over to humans than previously appreciated. We determined the structures of the CCoV-HuPn-2018 spike glycoprotein trimer in two distinct conformational states and showed that its domain 0 recognizes sialosides.
M. Alejandra Tortorici, Alexandra C. Walls, Anshu Joshi, Young-Jun Park, Rachel T. Eguia, Marcos C. Miranda, Elizabeth Kepl, Annie Dosey, Terry Stevens-Ayers, Michael J. Boeckh, Amalio Telenti, Antonio Lanzavecchia, Neil P. King, Davide Corti, Jesse D. Bloom, David Veesler   +15 more
openaire   +2 more sources

Repositioning of Ligands That Target the Spike Glycoprotein as Potential Drugs for SARS-CoV-2 in an In Silico Study

Molecules, 2020
The worldwide health emergency of the SARS-CoV-2 pandemic and the absence of a specific treatment for this new coronavirus have led to the use of computational strategies (drug repositioning) to search for treatments.
Gema Lizbeth Ramírez-Salinas, Marlet Martínez-Archundia, José Correa-Basurto, Jazmín García-Machorro   +3 more
doaj   +1 more source

Differential maturation and subcellular localization of severe acute respiratory syndrome coronavirus surface proteins S, M and E [PDF]

, 2005
Post-translational modifications and correct subcellular localization of viral structural proteins are prerequisites for assembly and budding of enveloped viruses. Coronaviruses, like the severe acute respiratory syndrome-associated virus (SARS-CoV), bud
Altmeyer, R, Chan, C, Chu, K, CrescenzoChaigne, B, Escriou, N, Kam, J, Kien, F, Nal, B, Siu, L, Staropoli, I, Tse, J, van der Wef, S, Yuen, KY   +12 more
core   +3 more sources

Conserved High Free Energy Sites in Human Coronavirus Spike Glycoprotein Backbones

Journal of Computational Biology, 2020
Methods previously developed by the author are applied to uncover several sites of interest in the spike glycoproteins of all known human coronaviruses (hCoVs), including SARS-CoV-2 that causes COVID-19. The sites comprise three-dimensional neighborhoods of peptides characterized by four key properties: (1) they pinpoint regions of high free energy in ...
openaire   +2 more sources

The consensus B-cell epitopes of SARS coronavirus spike glycoprotein

, 2020
The goal of this paper is to obtain the consensus B-cell epitopes calculated from the spike glycoprotein of SARS-CoV, after an analysis of 946 epitopes predicted by thirteen different computer programs. To reduce and select the best epitopes, we define a function called $<F>$ that includes energy and structural factors obtained from the changes ...
Isea, Raul, Vega, Cristóbal
openaire   +1 more source

Structure-guided covalent stabilization of coronavirus spike glycoprotein trimers in the closed conformation

Nature Structural & Molecular Biology, 2020
AbstractSARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections and more than 500,000 fatalities by June 2020. To initiate infection, the SARS-CoV-2 spike (S) glycoprotein promotes attachment to the host cell surface and fusion of the viral and host membranes.
McCallum, Matthew, Walls, Alexandra C., Bowen, John E., Corti, Davide, Veesler, David   +4 more
openaire   +2 more sources

Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015

Emerging Infectious Diseases, 2016
An outbreak of nosocomial infections with Middle East respiratory syndrome coronavirus occurred in South Korea in May 2015. Spike glycoprotein genes of virus strains from South Korea were closely related to those of strains from Riyadh, Saudi Arabia ...
Dae-Won Kim, You-Jin Kim, Sung Han Park, Mi-Ran Yun, Jeong-Sun Yang, Hae Ji Kang, Young Woo Han, Han Saem Lee, Heui Man Kim, Hak Kim, A-Reum Kim, Deok Rim Heo, Su Jin Kim, Jun Ho Jeon, Deokbum Park, Joo Ae Kim, Hyang-Min Cheong, Jeong-Gu Nam, Kisoon Kim, Sung Soon Kim   +19 more
doaj   +1 more source