Results 71 to 80 of about 40,476 (180)

The consensus B-cell epitopes of SARS coronavirus spike glycoprotein

, 2020
The goal of this paper is to obtain the consensus B-cell epitopes calculated from the spike glycoprotein of SARS-CoV, after an analysis of 946 epitopes predicted by thirteen different computer programs. To reduce and select the best epitopes, we define a function called $<F>$ that includes energy and structural factors obtained from the changes ...
Isea, Raul, Vega, Cristóbal
openaire   +2 more sources

Retargeting of Coronavirus by Substitution of the Spike Glycoprotein Ectodomain: Crossing the Host Cell Species Barrier [PDF]

Journal of Virology, 2000
ABSTRACTCoronaviruses generally have a narrow host range, infecting one or just a few species. Using targeted RNA recombination, we constructed a mutant of the coronavirus mouse hepatitis virus (MHV) in which the ectodomain of the spike glycoprotein (S) was replaced with the highly divergent ectodomain of the S protein of feline infectious peritonitis ...
Kuo, L., Godeke, G.J., Raamsman, M.J., Masters, P.S., Rottier, P.J.M.   +4 more
openaire   +4 more sources

Understanding the Molecular Actions of Spike Glycoprotein in SARS-CoV-2 and Issues of a Novel Therapeutic Strategy for the COVID-19 Vaccine

BioMedInformatics
In vaccine development, many use the spike protein (S protein), which has multiple “spike-like” structures protruding from the spherical structure of the coronavirus, as an antigen. However, there are concerns about its effectiveness and toxicity. When S
Yasunari Matsuzaka, Ryu Yashiro
doaj   +1 more source

Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo‐electron microscopy [PDF]

Protein Science, 2016
AbstractThe tremendous pandemic potential of coronaviruses was demonstrated twice in the last 15 years by two global outbreaks of deadly pneumonia. Entry of coronaviruses into cells is mediated by the transmembrane spike glycoprotein S, which forms a trimer carrying receptor‐binding and membrane fusion functions.
Walls, Alexandra, Tortorici, M. Alejandra, Bosch, Berend-Jan, Frenz, Brandon, Rottier, Peter J. M., Dimaio, Frank, Rey, Félix A., Veesler, David   +7 more
openaire   +4 more sources

Mechanistic insights into ligand dissociation from the SARS-CoV-2 spike glycoprotein.

PLoS Computational Biology
The COVID-19 pandemic, driven by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spurred an urgent need for effective therapeutic interventions.
Timothy Hasse, Esra Mantei, Rezvan Shahoei, Shristi Pawnikar, Jinan Wang, Yinglong Miao, Yu-Ming M Huang   +6 more
doaj   +1 more source

Interaction of Human ACE2 to Membrane-Bound SARS-CoV-1 and SARS-CoV-2 S Glycoproteins

Viruses, 2020
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is responsible for the current global coronavirus disease 2019 (COVID-19) pandemic, infecting millions of people and causing hundreds of thousands of deaths.
Sai Priya Anand, Yaozong Chen, Jérémie Prévost, Romain Gasser, Guillaume Beaudoin-Bussières, Cameron F. Abrams, Marzena Pazgier, Andrés Finzi   +7 more
doaj   +1 more source

Potential antiviral peptides targeting the SARS-CoV-2 spike protein

BMC Pharmacology and Toxicology, 2022
Background The coronavirus disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection became an international pandemic and created a public health crisis.
Ibrahim Khater, Aaya Nassar
doaj   +1 more source

Designing of multi-Epitope vaccine against spike glycoprotein of SARS-CoV-2 using immunoinformatics approach

Medicine in Omics
Background: COVID-19 caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome) has created an alarming situation worldwide. The surface (S) glycoprotein of novel coronavirus, encoded by the genome of SARS-CoV-2, plays an role in attachment, fusion as well
Deepak Kumar Jha, Niti Yashvardhini, Amit Kumar, Manjush Gaurav, Kumar Sayrav   +4 more
doaj   +1 more source

Targeting Middle East Respiratory Syndrome Coronavirus Spike Fusion Machinery With Antiviral Peptides: In Silico Exploration of the Heptad Repeat 2 Domain

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq, Doni Dermawan, Samir Chtita   +2 more
wiley   +1 more source

Analysis of the S spike (peplomer) glycoprotein of bovine coronavirus synthesized in insect cells

Virology, 1990
The bovine coronavirus (BCV) spike glycoprotein precursor (S, formerly termed peplomer) and its two subunit polypeptides (S1 and S2) were individually expressed in Spodoptera frugiperda (Sf9) insect cells. Each recombinant baculovirus expressed both glycosylated (S, 170K; S1, 95K; S2, 80K) and unglycosylated (S0, 140K; S10, 75K; and S20, 65K) forms of ...
Yoo, Dongwan, Parker, Michael D., Babiuk, Lorne A.   +2 more
openaire   +2 more sources