Results 51 to 60 of about 40,476 (180)

SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants

Frontiers in Immunology, 2021
Coronavirus 19 Disease (COVID-19) originating in the province of Wuhan, China in 2019, is caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), whose infection in humans causes mild or severe clinical manifestations that mainly
Daniel Martínez-Flores, Jesús Zepeda-Cervantes, Jesús Zepeda-Cervantes, Adolfo Cruz-Reséndiz, Sergio Aguirre-Sampieri, Alicia Sampieri, Luis Vaca   +6 more
doaj   +1 more source

Identification of a Receptor-Binding Domain of the Spike Glycoprotein of Human Coronavirus HCoV-229E [PDF]

Journal of Virology, 2003
ABSTRACTHuman coronavirus HCoV-229E uses human aminopeptidase N (hAPN) as its receptor (C. L. Yeager et al., Nature357:420-422, 1992). To identify the receptor-binding domain of the viral spike glycoprotein (S), we expressed soluble truncated histidine-tagged S glycoproteins by using baculovirus expression vectors.
Aurelio, Bonavia, Bruce D, Zelus, David E, Wentworth, Pierre J, Talbot, Kathryn V, Holmes   +4 more
openaire   +2 more sources

Repositioning of Ligands That Target the Spike Glycoprotein as Potential Drugs for SARS-CoV-2 in an In Silico Study

Molecules, 2020
The worldwide health emergency of the SARS-CoV-2 pandemic and the absence of a specific treatment for this new coronavirus have led to the use of computational strategies (drug repositioning) to search for treatments.
Gema Lizbeth Ramírez-Salinas, Marlet Martínez-Archundia, José Correa-Basurto, Jazmín García-Machorro   +3 more
doaj   +1 more source

Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer Simulations

Frontiers in Immunology, 2021
SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1 domain of the spike glycoprotein of SARS-CoV-2 binds to human angiotensin-converting enzyme 2 (hACE2) via its receptor-binding domain, while the S2 domain facilitates fusion
Damiano Buratto, Abhishek Saxena, Qun Ji, Guang Yang, Sergio Pantano, Sergio Pantano, Francesco Zonta   +6 more
doaj   +1 more source

Molecular modelling of S1 and S2 subunits of SARS coronavirus spike glycoprotein

Biochemical and Biophysical Research Communications, 2003
The S1 and S2 subunits of the spike glycoprotein of the coronavirus which is responsible for the severe acute respiratory syndrome (SARS) have been modelled, even though the corresponding amino acid sequences were not suitable for tertiary structure predictions with conventional homology and/or threading procedures.
Spiga, Ottavia, Bernini, A., Ciutti, A., Chiellini, S., Menciassi, N., Finetti, F., Causarano, V., Anselmi, F., Prischi, F., Niccolai, Neri   +9 more
openaire   +4 more sources

Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015

Emerging Infectious Diseases, 2016
An outbreak of nosocomial infections with Middle East respiratory syndrome coronavirus occurred in South Korea in May 2015. Spike glycoprotein genes of virus strains from South Korea were closely related to those of strains from Riyadh, Saudi Arabia ...
Dae-Won Kim, You-Jin Kim, Sung Han Park, Mi-Ran Yun, Jeong-Sun Yang, Hae Ji Kang, Young Woo Han, Han Saem Lee, Heui Man Kim, Hak Kim, A-Reum Kim, Deok Rim Heo, Su Jin Kim, Jun Ho Jeon, Deokbum Park, Joo Ae Kim, Hyang-Min Cheong, Jeong-Gu Nam, Kisoon Kim, Sung Soon Kim   +19 more
doaj   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis Virus [PDF]

Journal of Virology, 2000
ABSTRACTDemyelination is the pathologic hallmark of the human immune-mediated neurologic disease multiple sclerosis, which may be triggered or exacerbated by viral infections. Several experimental animal models have been developed to study the mechanism of virus-induced demyelination, including coronavirus mouse hepatitis virus (MHV) infection in mice.
J, Das Sarma, L, Fu, J C, Tsai, S R, Weiss, E, Lavi   +4 more
openaire   +2 more sources

Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1

Nature Communications, 2017
Human coronavirus HKU1 can cause severe respiratory diseases in young children and immunocompromised patients. Here, the authors present the structure of the C-terminal domain of the viral spike glycoprotein S1 subunit, which is important for host cell ...
Xiuyuan Ou, Hongxin Guan, Bo Qin, Zhixia Mu, Justyna A. Wojdyla, Meitian Wang, Samuel R. Dominguez, Zhaohui Qian, Sheng Cui   +8 more
doaj   +1 more source

Development of a novel platform of virus-like particle (VLP)-based vaccine against COVID-19 by exposing epitopes: an immunoinformatics approach

New Microbes and New Infections, 2020
The emergence of a rapidly spreading and highly infectious coronavirus disease 2019 (COVID-19) outbreak by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a global pandemic with unprecedented social and ...
A. Ghorbani, F. Zare, S. Sazegari, A. Afsharifar, M.H. Eskandari, A. Pormohammad   +5 more
doaj   +1 more source