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Immune Responses in SARS-CoV-2, SARS-CoV, and MERS-CoV Infections: A Comparative Review
, 2022 Coronavirus, discovered in the 1960s, is able to infect human hosts and causes mild to serious respiratory problems. In the last two decades, the severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-
Irani, Soussan
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, 2022 MERS-CoV infection can damage the cellular metabolic processes, but the underlying mechanisms are largely unknown. Through screening, we found non-structural protein 1 (nsp1) of MERS-CoV could inhibit cell viability, cell cycle, and cell migration ...
Yujie Feng (1362966) +5 more
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A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines. [PDF]
PLoS ONE, 2013 An emerging respiratory infectious disease with high mortality, Middle East respiratory syndrome (MERS), is caused by a novel coronavirus (MERS-CoV). It was first reported in 2012 in Saudi Arabia and has now spread to eight countries.
Lanying Du +10 more
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EClinicalMedicine, 2021 Background: Of the three lethal coronaviruses, in addition to the ongoing pandemic-causing SARS-CoV 2, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) remains in circulation. Information on MERS-CoV has relied on small sample of patients.
Shahul H. Ebrahim, MD, PhD +7 more
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An optimised method for the production of MERS-CoV spike expressing viral pseudotypes [PDF]
, 2015 The production and use of pseudotyped viral particles is widely established for many viruses, and applications in the fields of serology and vaccine development are manifold.
Ferrara, Francesca +5 more
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MERS-CoV nsp1 regulates autophagic flux via mTOR signalling and dysfunctional lysosomes
, 2022 Autophagy, a cellular surveillance mechanism, plays an important role in combating invading pathogens. However, viruses have evolved various strategies to disrupt autophagy and even hijack it for replication and release. Here, we demonstrated that Middle
Yujie Feng (1362966) +9 more
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Emerging Microbes and Infections, 2019 In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%.
Danielle R. Adney +6 more
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Characterization of MERS-CoV-MA-Δ4b and MERS-CoV-MA-mNLS mutants.
, 2022 (A) Huh-7 cells were infected with MERS-CoV-MA, MERS-CoV-MA-Δ4b or MERS-CoV-MA-mNLS at a m.o.i. of 0.1 for 24 h and the localization of 4b (in green) was analyzed by confocal microscopy.
Isabel Sola (218107) +7 more
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SVU - International Journal of Medical Sciences, 2023 Background: Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic was a serious healthcare concern not responding to conventional anti-viral therapies between 2012 and 2017 with high fatality rates.
Mariam Eid Alanzi +30 more
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Virulence of MERS-CoV-MA-Δ4b and MERS-CoV-MA-mNLS in mice.
, 2022 30-week-old hDPP4-KI mice were intranasally inoculated with 5x104 pfu of MERS-CoV-MA-WT (WT), MERS-CoV-MA-Δ4b (Δ4b) or MERS-CoV-MA-mNLS (mNLS) viruses. Weight loss (A) and survival (B) were monitored for 12 days.
Isabel Sola (218107) +7 more
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