Results 21 to 30 of about 41,690 (230)

Crystal structure of the membrane (M) protein from a bat betacoronavirus

PNAS Nexus, 2023
The membrane (M) protein is the most abundant structural protein of coronaviruses including MERS-CoV, SARS-CoV, and SARS-CoV-2, and plays a central role in virus assembly through its interaction with various partner proteins. However, mechanistic details
Xiaodong Wang, Yu-Wei Yang, Ziyi Sun, Xiaoming Zhou   +3 more
semanticscholar   +3 more sources

Discovery of a novel Betacoronavirus 1, cpCoV, in goats in China: The new risk of cross-species transmission

PLoS Pathogens
Betacoronavirus is a causative agent of respiratory and enteric diseases in humans and animals. Several ruminants are recognized to be intermediate hosts in the transmission of emerging coronaviruses from reservoir hosts to humans.
Li Mao, Xuhang Cai, Ji-Zong Li, Xia Li, Siyuan Li, Wen-Liang Li, Honghui Lu, Yi-Chun Dong, Junjun Zhai, Xin-Gang Xu, Bin Li   +10 more
semanticscholar   +2 more sources

Conserved Characteristics of NMPylation Activities of Alpha- and Betacoronavirus NiRAN Domains

Journal of Virology, 2023
There is strong evidence that coronaviruses and other large nidoviruses evolved a number of unique enzymatic activities, including an additional RdRp-associated NiRAN domain, that are conserved in nidoviruses but not in most other RNA viruses.
H. Slanina, Ramakanth Madhugiri, Kai Wenk, Tess Reinke, Karin Schultheiß, J. Schultheis, Nadja Karl, U. Linne, J. Ziebuhr   +8 more
semanticscholar   +3 more sources

Betacoronavirus Infection Outbreak, São Paulo, Brazil, Fall 2023

Emerging Infectious Diseases
We report a human coronavirus OC43 infection outbreak in hospitalized patients and healthcare workers in São Paulo, Brazil, occurring after SARS-CoV-2 cases disappeared. Infection was associated with healthcare workers in 5 (29.4%) patients.
Tânia do Socorro Souza Chaves, Ana H. Perosa, Gabriela Barbosa, Diogo B. Ferreira, Nancy Bellei   +4 more
doaj   +3 more sources

Transcriptome Analysis in Air–Liquid Interface Porcine Respiratory Epithelial Cell Cultures Reveals That the Betacoronavirus Porcine Encephalomyelitis Hemagglutinating Virus Induces a Robust Interferon Response to Infection

Viruses
Porcine hemagglutinating encephalomyelitis virus (PHEV) replicates in the upper respiratory tract and tonsils of pigs. Using an air–liquid interface porcine respiratory epithelial cells (ALI-PRECs) culture system, we demonstrated that PHEV disrupts ...
Kaitlyn M. Sarlo Davila, Rahul K. Nelli, Juan C. Mora-Díaz, Yongming Sang, Laura C. Miller, Luis G. Giménez-Lirola   +5 more
doaj   +2 more sources

Protective pan-betacoronavirus neutralizing antibodies by vaccination

bioRxiv
The continued emergence of betacoronaviruses underscores the urgent need for vaccines that provide broadly protective immunity. Here, we present an epitope-focused vaccine strategy targeting the conserved S2 stem-helix region of the spike fusion ...
Pan-Pan Zhou, Zi-Qi Feng, Wan-ting He, Yu-Xin Zhu, M. Yuan, Xuduo Li, Yue-Xiu Zhang, Lina Vo, Tazio Capozzola, Sean Callaghan, Nitesh Mishra, Gabriel B. Avillion, K. Dueker, Bo Liang, Rohan Roy Chowdhury, R. Nedellec, W. Lee, J. D. Allen, Agnes A. Walsh, Mariane B. Melo, Eileen T. McAnarney, N. Kumar, William J Rinaldi, Melissa J. Ferguson, M. Crispin, Andrew B. Ward, Darrell J. Irvine, M. Alameh, Drew Weissman, R. Baric, Lisa E. Gralinski, Ian A. Wilson, D. R. Burton, R. Andrabi   +33 more
semanticscholar   +2 more sources

Mapping Sub-National Respiratory Virus Circulation in Cambodia Using Metatranscriptomic Sequencing: A Multi-Center Hospital-Based Surveillance Study. [PDF]

Influenza Other Respir Viruses
ABSTRACT Background Genomic surveillance can guide early detection of and response to emerging epidemics. Metatranscriptomic sequencing was used to investigate sub‐national respiratory virus circulation in Cambodia from 2020 to 2023. Methods Nasopharyngeal swabs were collected from individuals aged 2 months to 65 years with influenza‐like illness in ...
Yek C, Sebastian J, Chea S, Lay S, Oum M, Long L, Chea S, Pacheco AR, Barochia M, Ly P, Ly S, Sath R, Parker DM, Minin VM, Chung M, Ghedin E, Oliveira F, Manning JE, Lean K, Ny C, Long V, Leang K, Yim V, Hok K, Leang R, Huy R, Chin S, Chau D, Seng H, Ly S, Lon C.   +30 more
europepmc   +2 more sources

Molecular Detection of Alpha- and Betacoronaviruses in Bats from Afar Region, Ethiopia. [PDF]

Vet Med Sci
Bats are critical reservoirs of coronaviruses, yet gaps remain in understanding coronavirus diversity within bat populations in Eastern Ethiopia. A total of 141 bats were captured: 129 Chaerephon pumilus, 11 Epomophorus labiatus and 1 Mops condylurus. Coronaviruses detected in eight bats.
Mengesha B, Romha G, Gebrezgabiher G.
europepmc   +2 more sources

<i>Ambecovirus</i>, a novel <i>Betacoronavirus</i> subgenus circulating in neotropical bats, sheds new light on bat-borne coronaviruses evolution. [PDF]

Virus Evol
Understanding the viral diversity harboured by wildlife is essential for effective prediction and prevention of future zoonotic outbreaks. Bats, in particular, are recognized as natural reservoirs for several zoonotic viral pathogens of high impact on ...
Wallau GDL, Barbier E, Machado LC, da Silva AF, Dias YJM, Dezordi FZ, Tomazatos A, Horváth B, Lins RD, Bernard E, Cadar D.   +10 more
europepmc   +2 more sources

Etiology of epidemic outbreaks COVID-19 in Wuhan, Hubei province, Chinese People Republic associated with 2019-nCoV (Nidovirales, Coronaviridae, Coronavirinae, Betacoronavirus, Subgenus Sarbecovirus): lessons of SARS-CoV outbreak

Вопросы вирусологии, 2020
Results of analysis of phylogenetic, virological, epidemiological, ecological, clinical data of COVID-19 outbreaks in Wuhan, China (PRC) in comparison with SARS-2002 and MERS-2012 outbreaks allow to conclude: – the etiological agent of COVID-19 is ...
D. K. Lvov, S. V. Alkhovsky, L. V. Kolobukhina, E. I. Burtseva   +3 more
doaj   +1 more source