Results 41 to 50 of about 23,278,336 (315)

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Grace and Power: Base Communities and Nonviolence in Brazil [PDF]

open access: yes, 1989
Reviewed Book: Barbé, Dominique. Grace and Power: Base Communities and Nonviolence in Brazil.
Snyder, C. Arnold
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Revue Annales du patrimoine numéro 19 [PDF]

open access: yesAnnales du Patrimoine, 2019
Revue Annales du patrimoine, Faculté des Lettres et des Arts, Université de Mostaganem, Algérie, N° 19/2019.
Pr Mohammed Abbassa
doaj  

Lectures of the Nobel Week 2019 organized at Villa Nobel in Sanremo, Italy; Villa Nobel, Sanremo (Italy); December 11, 2019

open access: yesJournal of Pediatric and Neonatal Individualized Medicine, 2019
Lectures of the Nobel Week 2019 organized at Villa Nobel in Sanremo, Italy THE NEWS OF SCIENCE FOR A SUSTAINABLE FUTURE [LE NOVITÀ DELLA SCIENZA PER UN FUTURO SOSTENIBILE] Villa Nobel • Sanremo (Italy) • December 11th, 2019 The meeting has been ...
--- Various Authors
doaj   +1 more source

Detecting Compaction Disequilibrium with Anisotropy of Magnetic Susceptibility [PDF]

open access: yes, 2006
In clay-rich sediment, microstructures and macrostructures influence how sediments deform when under stress. When lithology is fairly constant, anisotropy of magnetic susceptibility (AMS) can be a simple technique for measuring the relative consolidation
Bennett   +63 more
core   +3 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Prime Minister Modi Returns, 2019: New Governance Agenda

open access: yesSpace and Culture, India, 2019
This editorial reviews the historic mandate of India's General Election of 2019, preceding nasty campaigns and futurist agenda for Mr Modi's second term.
Rituparna Bhattacharyya, Venkat Pulla
doaj   +1 more source

Freight mode choice and adaptive stated preferences

open access: yes, 2002
This paper presents empirical results from a survey of determinants of mode choice for freight in India. The Leeds Adaptive Stated Preference software was used for the main survey which was carried out in summer 1998 on the Delhi to Bombay corridor.
Fowkes, A.S., Shinghal, N.
core   +2 more sources

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